Basic Information
ID: ALA3825093
Type: Binding
Description: Antagonist activity at human iGluA1 receptor flop isoform expressed in CHO-S cells coexpressing TARP gamma-8 and human EAAT3 assessed as inhibition of glutamate-induced increase in intracellular calcium levels after 2 mins followed by cyclothiazide/glutamate addition by fluo-4 AM dye based fluorescence imaging plate reader method
Format: BAO_0000219
Organism: Homo sapiens
Cell type: CHO-S
Target: Glutamate receptor ionotropic, AMPA 1(ALA2009)
Document: ALA3822422
Antagonist activity at human iGluA1 receptor flop isoform expressed in CHO-S cells coexpressing TARP gamma-8 and human EAAT3 assessed as inhibition of glutamate-induced increase in intracellular calcium levels after 2 mins followed by cyclothiazide/glutamate addition by fluo-4 AM dye based fluorescence imaging plate reader method: 1
Activity Charts
Bioactivity
Activity Types for Assay ALA3825093
IC50
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 349.39 | 4.44 | 4.44 |
| 283.36 | 3.68 | 3.68 |
| 307.38 | 3.85 | 3.85 |
| 290.33 | 2.91 | 2.91 |
| 340.43 | 3.88 | 3.88 |
| 322.39 | 3.32 | 3.32 |
| 322.39 | 3.32 | 3.32 |
| 322.39 | 3.32 | 3.32 |
| 387.47 | 4.15 | 4.15 |
| 340.38 | 3.46 | 3.46 |
| 408.53 | 4.03 | 4.03 |
| 366.45 | 2.86 | 2.86 |
| 366.45 | 2.86 | 2.86 |
| 382.45 | 2.69 | 2.69 |
| 382.45 | 2.69 | 2.69 |
| 398.51 | 4.28 | 4.28 |