Basic Information
ID: ALA3825540
Type: Binding
Description: Inhibition of human recombinant Top1 expressed in baculovirus using [32P]-3-end labeled 117 bp DNA oligonucleotide as substrate assessed as enzyme mediated DNA cleavage after 20 mins by SDS-PAGE analysis relative to camptothecin
Organism: Homo sapiens
Activity Charts
Bioactivity
Activity Types for Assay ALA3825540
Activity
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 478.50 | 2.68 | 2.68 |
| 464.47 | 2.38 | 2.38 |
| 464.47 | 2.38 | 2.38 |
| 578.57 | 2.53 | 2.53 |
| 535.55 | 2.73 | 2.73 |
| 506.51 | 2.60 | 2.60 |
| 578.57 | 2.53 | 2.53 |
| 568.58 | 3.89 | 3.89 |
| 569.57 | 3.29 | 3.29 |