Basic Information
ID: ALA3826279
Type: Binding
Description: Inhibition of PRC2 EZH2 sub unit (unknown origin) assessed as inhibition of SAM-mediated methyl transfer process at 50 uM preincubated for 15 mins followed by addition of H3K27me and [3H]SAM as substrate measured after 90 mins by radioactive methylation assay
Organism: Homo sapiens
Activity Charts
Bioactivity
Activity Types for Assay ALA3826279
Inhibition
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 484.00 | 4.70 | 4.70 |
| 317.39 | 4.09 | 4.09 |
| 463.53 | 3.31 | 3.31 |
| 498.35 | 4.23 | 4.23 |
| 300.75 | 3.28 | 3.28 |
| 327.34 | 2.33 | 2.33 |
| 215.26 | 1.15 | 1.15 |
| 457.52 | 3.75 | 3.75 |
| 208.29 | 1.61 | 1.61 |
| 306.32 | 3.03 | 3.03 |
| 215.26 | 1.81 | 1.81 |
| 337.38 | 3.06 | 3.06 |
| 385.85 | 4.35 | 4.35 |
| 427.52 | 3.64 | 3.64 |
| 364.45 | 1.21 | 1.21 |
| 310.27 | 1.77 | 1.77 |
| 457.52 | 3.75 | 3.75 |
| 343.39 | 4.15 | 4.15 |
| 417.46 | 4.74 | 4.74 |
| 387.44 | 4.73 | 4.73 |
| 473.52 | 3.45 | 3.45 |
| 269.32 | 2.48 | 2.48 |
| 446.02 | 3.60 | 3.60 |
| 436.92 | 5.02 | 5.02 |
| 442.15 | 3.26 | 3.26 |
| 431.52 | 4.42 | 4.42 |
| 301.30 | 0.29 | 0.29 |
| 356.47 | 4.60 | 4.60 |
| 217.25 | 2.31 | 2.31 |
| 355.83 | 3.43 | 3.43 |
| 384.82 | 4.89 | 4.89 |
| 324.45 | 2.50 | 2.50 |
| 346.39 | 2.59 | 2.59 |
| 411.51 | 4.00 | 4.00 |
| 449.56 | 5.26 | 5.26 |
| 387.41 | 5.29 | 5.29 |
| 354.88 | 4.03 | 4.03 |
| 392.50 | 6.02 | 6.02 |
| 353.42 | 5.69 | 5.69 |
| 357.37 | 3.93 | 3.93 |
| 380.47 | 3.13 | 3.13 |
| 452.63 | 5.67 | 5.67 |
| 380.45 | 4.25 | 4.25 |
| 304.35 | 4.00 | 4.00 |
| 446.38 | 5.91 | 5.91 |
| 326.36 | 4.95 | 4.95 |
| 214.27 | 2.09 | 2.09 |
| 397.50 | 5.75 | 5.75 |
| 399.45 | 3.93 | 3.93 |
| 368.40 | 3.88 | 3.88 |
| 290.33 | 2.33 | 2.33 |
| 425.35 | 5.55 | 5.55 |
| 390.51 | 5.24 | 5.24 |
| 354.37 | 3.99 | 3.99 |
| 436.47 | 4.45 | 4.45 |
| 336.38 | 3.56 | 3.56 |
| 388.47 | 6.62 | 6.62 |
| 318.37 | 4.44 | 4.44 |
| 409.42 | 1.72 | 1.72 |
| 307.33 | 1.99 | 1.99 |
| 488.38 | 6.71 | 6.71 |
| 280.33 | 5.20 | 5.20 |
| 344.41 | 5.08 | 5.08 |
| 201.23 | 2.23 | 2.23 |
| 215.26 | 2.54 | 2.54 |
| 259.29 | 2.69 | 2.69 |
| 313.79 | 3.98 | 3.98 |
| 339.40 | 3.03 | 3.03 |
| 371.49 | 4.52 | 4.52 |
| 443.50 | 3.03 | 3.03 |
| 326.39 | 1.86 | 1.86 |
| 257.30 | 1.91 | 1.91 |
| 279.30 | 4.20 | 4.20 |
| 373.42 | 3.75 | 3.75 |
| 373.42 | 3.75 | 3.75 |
| 404.43 | 2.24 | 2.24 |
| 259.27 | 2.24 | 2.24 |
| 328.49 | 4.49 | 4.49 |
| 266.30 | 2.96 | 2.96 |
| 243.27 | 2.32 | 2.32 |
| 256.31 | 2.80 | 2.80 |