Basic Information
ID: ALA3854641
Type: Binding
Description: Inhibition of human DNA polymerase kappa (19 to 526 residues)-mediated TLS past acrolein derived ring-opened reduced form of gamma-HOPdG lesions preincubated for 15 mins followed by DNA substrate addition measured after 30 mins in presence of dCTP and dGTP by radioactive gel-based primer extension assay
Organism: Homo sapiens
Activity Charts
Bioactivity
Activity Types for Assay ALA3854641
IC50
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 610.67 | 6.32 | 6.32 |
| 416.56 | 4.86 | 4.86 |
| 473.12 | 8.49 | 8.49 |