Basic Information
ID: ALA3857094
Type: ADME
Description: Inhibition of CYP2C19 in human liver microsomes assessed as remaining activity by measuring S-mephenytoin 4-hydroxylase activity at 10 uM pre-incubated for 5 mins followed by NADPH regenerating system addition by LC-MS/MS analysis relative to control
Organism: Homo sapiens
Tissue: Liver
Subcellular Fraction: Microsomes
Activity Charts
Bioactivity
Activity Types for Assay ALA3857094
Activity
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 468.04 | 5.45 | 5.45 |
| 454.01 | 5.06 | 5.06 |
| 473.99 | 6.34 | 6.34 |
| 482.06 | 5.84 | 5.84 |
| 456.00 | 6.04 | 6.04 |
| 439.98 | 4.72 | 4.72 |
| 452.04 | 5.67 | 5.67 |
| 516.91 | 6.12 | 6.12 |