Basic Information
ID: ALA3858376
Type: Binding
Description: Antagonist activity at recombinant human P2X7 receptor expressed in human 1321N1 cells assessed as inhibition of Bz-ATP-induced Ca2+ flux preincubated for 30 mins followed by agonist addition measured after 180 sec by calcium-4 dye based FLIPR assay
Organism: Homo sapiens
Cell type: 1321-N1
Activity Charts
Bioactivity
Activity Types for Assay ALA3858376
IC50
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 391.23 | 3.91 | 3.91 |
| 438.81 | 4.84 | 4.84 |
| 421.81 | 4.09 | 4.09 |
| 419.83 | 5.30 | 5.30 |
| 439.80 | 4.23 | 4.23 |
| 437.82 | 5.44 | 5.44 |
| 406.80 | 4.14 | 4.14 |
| 372.25 | 4.38 | 4.38 |
| 421.81 | 4.09 | 4.09 |
| 439.80 | 4.23 | 4.23 |
| 438.81 | 4.84 | 4.84 |
| 437.82 | 5.44 | 5.44 |
| 424.79 | 4.28 | 4.28 |
| 408.33 | 3.76 | 3.76 |
| 407.78 | 3.53 | 3.53 |
| 404.37 | 3.93 | 3.93 |
| 420.82 | 4.70 | 4.70 |
| 405.81 | 4.74 | 4.74 |
| 420.82 | 4.70 | 4.70 |
| 438.81 | 4.84 | 4.84 |