Basic Information
ID: ALA3859042
Type: Binding
Description: Inhibition of human full length PRMT4 (1 to 608 residues) expressed in 293F cells assessed as inhibition of methylation activity preincubated with protein followed by addition of biotin labeled histone H3 (1 to 25) peptide as substrate and [3H]-SAM measured after 3 hrs by scintillation proximity assay
Organism: Homo sapiens
Cell type: MT4
Activity Charts
Bioactivity
Activity Types for Assay ALA3859042
IC50
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 234.34 | 1.75 | 1.75 |
| 316.37 | 2.91 | 2.91 |
| 246.40 | 2.55 | 2.55 |
| 262.40 | 1.52 | 1.52 |
| 218.34 | 2.09 | 2.09 |
| 261.37 | 1.56 | 1.56 |
| 304.48 | 3.09 | 3.09 |
| 327.27 | 2.65 | 2.65 |
| 250.41 | 2.46 | 2.46 |
| 262.35 | 1.53 | 1.53 |
| 318.51 | 3.57 | 3.57 |
| 282.82 | 2.54 | 2.54 |
| 246.40 | 2.55 | 2.55 |
| 233.36 | 1.78 | 1.78 |
| 266.36 | 2.03 | 2.03 |
| 232.37 | 2.16 | 2.16 |
| 316.37 | 2.91 | 2.91 |
| 266.36 | 2.03 | 2.03 |
| 332.37 | 2.79 | 2.79 |
| 346.39 | 2.83 | 2.83 |
| 249.35 | 2.31 | 2.31 |
| 232.37 | 2.16 | 2.16 |
| 327.27 | 2.65 | 2.65 |
| 330.52 | 3.93 | 3.93 |
| 282.82 | 2.54 | 2.54 |
| 324.47 | 3.55 | 3.55 |
| 248.37 | 1.65 | 1.65 |
| 282.82 | 2.54 | 2.54 |
| 266.36 | 2.03 | 2.03 |
| 342.49 | 2.69 | 2.69 |
| 324.47 | 3.55 | 3.55 |
| 316.37 | 2.91 | 2.91 |
| 261.37 | 1.10 | 1.10 |
| 248.37 | 1.89 | 1.89 |
| 247.39 | 2.03 | 2.03 |
| 218.34 | 1.77 | 1.77 |
| 324.47 | 3.55 | 3.55 |
| 276.38 | 1.77 | 1.77 |
| 248.37 | 2.00 | 2.00 |
| 327.27 | 2.65 | 2.65 |
| 409.36 | 4.99 | 4.99 |
| 246.40 | 2.55 | 2.55 |