Inhibition of human full length PRMT4 (1 to 608 residues) expressed in 293F cells assessed as inhibition of methylation activity preincubated with pro...

Basic Information

ID: ALA3859042

Type: Binding

Description: Inhibition of human full length PRMT4 (1 to 608 residues) expressed in 293F cells assessed as inhibition of methylation activity preincubated with protein followed by addition of biotin labeled histone H3 (1 to 25) peptide as substrate and [3H]-SAM measured after 3 hrs by scintillation proximity assay

Format: BAO_0000219

Organism: Homo sapiens

Cell type: MT4

Target: Histone-arginine methyltransferase CARM1(ALA5406)

Document: ALA3856251

Inhibition of human full length PRMT4 (1 to 608 residues) expressed in 293F cells assessed as inhibition of methylation activity preincubated with protein followed by addition of biotin labeled histone H3 (1 to 25) peptide as substrate and [3H]-SAM measured after 3 hrs by scintillation proximity assay: 1

Associated Items: Associated Bioactivities Associated Compounds

Activity Charts

Bioactivity

Activity Types for Assay ALA3859042

IC50

Total(42)

Compound Summary

Parent Molecular Weight	ALogP	Polar Surface Area
234.34	1.75	1.75
316.37	2.91	2.91
246.40	2.55	2.55
262.40	1.52	1.52
218.34	2.09	2.09
261.37	1.56	1.56
304.48	3.09	3.09
327.27	2.65	2.65
250.41	2.46	2.46
262.35	1.53	1.53
318.51	3.57	3.57
282.82	2.54	2.54
246.40	2.55	2.55
233.36	1.78	1.78
266.36	2.03	2.03
232.37	2.16	2.16
316.37	2.91	2.91
266.36	2.03	2.03
332.37	2.79	2.79
346.39	2.83	2.83
249.35	2.31	2.31
232.37	2.16	2.16
327.27	2.65	2.65
330.52	3.93	3.93
282.82	2.54	2.54
324.47	3.55	3.55
248.37	1.65	1.65
282.82	2.54	2.54
266.36	2.03	2.03
342.49	2.69	2.69
324.47	3.55	3.55
316.37	2.91	2.91
261.37	1.10	1.10
248.37	1.89	1.89
247.39	2.03	2.03
218.34	1.77	1.77
324.47	3.55	3.55
276.38	1.77	1.77
248.37	2.00	2.00
327.27	2.65	2.65
409.36	4.99	4.99
246.40	2.55	2.55