Basic Information
ID: ALA3859043
Type: Binding
Description: Inhibition of human full length PRMT6 (1 to 375 residues) expressed in baculovirus expression system assessed as inhibition of methylation activity preincubated with protein followed by addition of biotin labeled histone H4 (1 to 24) peptide as substrate and [3H]-SAM measured after 3 hrs by scintillation proximity assay
Organism: Homo sapiens
Activity Charts
Bioactivity
Activity Types for Assay ALA3859043
IC50
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 234.34 | 1.75 | 1.75 |
| 316.37 | 2.91 | 2.91 |
| 246.40 | 2.55 | 2.55 |
| 262.40 | 1.52 | 1.52 |
| 218.34 | 2.09 | 2.09 |
| 261.37 | 1.56 | 1.56 |
| 304.48 | 3.09 | 3.09 |
| 327.27 | 2.65 | 2.65 |
| 250.41 | 2.46 | 2.46 |
| 262.35 | 1.53 | 1.53 |
| 318.51 | 3.57 | 3.57 |
| 282.82 | 2.54 | 2.54 |
| 246.40 | 2.55 | 2.55 |
| 233.36 | 1.78 | 1.78 |
| 266.36 | 2.03 | 2.03 |
| 232.37 | 2.16 | 2.16 |
| 316.37 | 2.91 | 2.91 |
| 266.36 | 2.03 | 2.03 |
| 332.37 | 2.79 | 2.79 |
| 346.39 | 2.83 | 2.83 |
| 249.35 | 2.31 | 2.31 |
| 232.37 | 2.16 | 2.16 |
| 327.27 | 2.65 | 2.65 |
| 330.52 | 3.93 | 3.93 |
| 282.82 | 2.54 | 2.54 |
| 324.47 | 3.55 | 3.55 |
| 248.37 | 1.65 | 1.65 |
| 282.82 | 2.54 | 2.54 |
| 266.36 | 2.03 | 2.03 |
| 342.49 | 2.69 | 2.69 |
| 324.47 | 3.55 | 3.55 |
| 316.37 | 2.91 | 2.91 |
| 261.37 | 1.10 | 1.10 |
| 248.37 | 1.89 | 1.89 |
| 247.39 | 2.03 | 2.03 |
| 218.34 | 1.77 | 1.77 |
| 324.47 | 3.55 | 3.55 |
| 276.38 | 1.77 | 1.77 |
| 248.37 | 2.00 | 2.00 |
| 327.27 | 2.65 | 2.65 |
| 409.36 | 4.99 | 4.99 |
| 246.40 | 2.55 | 2.55 |