Inhibition of human full length PRMT6 (1 to 375 residues) expressed in baculovirus expression system assessed as inhibition of methylation activity pr...

Basic Information

ID: ALA3859043

Type: Binding

Description: Inhibition of human full length PRMT6 (1 to 375 residues) expressed in baculovirus expression system assessed as inhibition of methylation activity preincubated with protein followed by addition of biotin labeled histone H4 (1 to 24) peptide as substrate and [3H]-SAM measured after 3 hrs by scintillation proximity assay

Format: BAO_0000019

Organism: Homo sapiens

Target: Protein arginine N-methyltransferase 6(ALA1275221)

Document: ALA3856251

Inhibition of human full length PRMT6 (1 to 375 residues) expressed in baculovirus expression system assessed as inhibition of methylation activity preincubated with protein followed by addition of biotin labeled histone H4 (1 to 24) peptide as substrate and [3H]-SAM measured after 3 hrs by scintillation proximity assay: 1

Associated Items: Associated Bioactivities Associated Compounds

Activity Charts

Bioactivity

Activity Types for Assay ALA3859043

IC50

Total(42)

Compound Summary

Parent Molecular Weight	ALogP	Polar Surface Area
234.34	1.75	1.75
316.37	2.91	2.91
246.40	2.55	2.55
262.40	1.52	1.52
218.34	2.09	2.09
261.37	1.56	1.56
304.48	3.09	3.09
327.27	2.65	2.65
250.41	2.46	2.46
262.35	1.53	1.53
318.51	3.57	3.57
282.82	2.54	2.54
246.40	2.55	2.55
233.36	1.78	1.78
266.36	2.03	2.03
232.37	2.16	2.16
316.37	2.91	2.91
266.36	2.03	2.03
332.37	2.79	2.79
346.39	2.83	2.83
249.35	2.31	2.31
232.37	2.16	2.16
327.27	2.65	2.65
330.52	3.93	3.93
282.82	2.54	2.54
324.47	3.55	3.55
248.37	1.65	1.65
282.82	2.54	2.54
266.36	2.03	2.03
342.49	2.69	2.69
324.47	3.55	3.55
316.37	2.91	2.91
261.37	1.10	1.10
248.37	1.89	1.89
247.39	2.03	2.03
218.34	1.77	1.77
324.47	3.55	3.55
276.38	1.77	1.77
248.37	2.00	2.00
327.27	2.65	2.65
409.36	4.99	4.99
246.40	2.55	2.55