Basic Information
ID: ALA3859769
Type: ADME
Description: Inhibition of human mitochondrial HSP60/HSP10-ATPase activity expressed in Escherichia coli DH5alpha/BL21 (DE3) assessed as inhibition of denatured MDH refolding preincubated for 10 mins followed by ATP addition measured after 40 to 60 mins by malachite green dye based fluorescence assay
Organism: Homo sapiens
Activity Charts
Bioactivity
Activity Types for Assay ALA3859769
IC50
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 340.43 | 2.88 | 2.88 |
| 287.30 | 0.64 | 0.64 |
| 182.17 | -0.23 | -0.23 |
| 1297.30 | ||
| 532.65 | 5.45 | 5.45 |
| 533.63 | 5.71 | 5.71 |
| 381.44 | 2.24 | 2.24 |
| 541.56 | 5.37 | 5.37 |
| 641.57 | 7.13 | 7.13 |
| 505.58 | 5.10 | 5.10 |
| 574.47 | 6.40 | 6.40 |
| 555.60 | 4.84 | 4.84 |
| 593.60 | 4.49 | 4.49 |
| 641.57 | 7.13 | 7.13 |
| 537.58 | 4.51 | 4.51 |
| 621.71 | 5.11 | 5.11 |
| 541.56 | 5.37 | 5.37 |
| 555.60 | 4.84 | 4.84 |
| 533.63 | 5.38 | 5.38 |
| 565.63 | 5.11 | 5.11 |
| 541.56 | 5.37 | 5.37 |
| 593.60 | 4.49 | 4.49 |
| 641.64 | 5.31 | 5.31 |
| 595.57 | 4.91 | 4.91 |
| 621.65 | 4.67 | 4.67 |
| 555.60 | 4.84 | 4.84 |
| 605.70 | 7.40 | 7.40 |
| 437.54 | 3.80 | 3.80 |
| 537.58 | 4.51 | 4.51 |
| 663.37 | 6.62 | 6.62 |
| 535.61 | 4.26 | 4.26 |
| 589.57 | 4.17 | 4.17 |
| 565.63 | 5.11 | 5.11 |
| 533.63 | 5.71 | 5.71 |
| 619.73 | 6.32 | 6.32 |
| 621.65 | 4.67 | 4.67 |
| 604.71 | 7.14 | 7.14 |
| 489.38 | 4.02 | 4.02 |
| 535.61 | 4.26 | 4.26 |
| 595.57 | 4.91 | 4.91 |
| 621.65 | 4.67 | 4.67 |
| 535.61 | 4.26 | 4.26 |
| 595.57 | 4.91 | 4.91 |
| 641.57 | 7.13 | 7.13 |
| 517.64 | 5.22 | 5.22 |
| 574.47 | 6.40 | 6.40 |
| 593.60 | 4.49 | 4.49 |
| 565.63 | 5.11 | 5.11 |
| 663.37 | 6.62 | 6.62 |
| 621.71 | 5.11 | 5.11 |
| 663.37 | 6.62 | 6.62 |
| 574.47 | 6.40 | 6.40 |
| 537.58 | 4.51 | 4.51 |