Basic Information
ID: ALA3861031
Type: Binding
Description: Inhibition of human NHE3 expressed in LAP1 cell assessed as intracellular pH recovery measured for 2 mins by CECF-AM dye based FLIPR assay
Organism: Homo sapiens
Cell type: LAP1
Activity Charts
Bioactivity
Activity Types for Assay ALA3861031
IC50
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 336.43 | 3.79 | 3.79 |
| 376.46 | 3.48 | 3.48 |
| 441.38 | 3.35 | 3.35 |
| 499.46 | 3.44 | 3.44 |
| 362.50 | 4.95 | 4.95 |
| 457.42 | 3.94 | 3.94 |
| 442.36 | 3.51 | 3.51 |
| 398.53 | 3.37 | 3.37 |
| 428.34 | 3.12 | 3.12 |
| 441.38 | 4.04 | 4.04 |
| 390.48 | 2.18 | 2.18 |
| 374.48 | 5.10 | 5.10 |
| 525.29 | 4.42 | 4.42 |
| 471.45 | 4.33 | 4.33 |
| 330.43 | 4.38 | 4.38 |
| 424.93 | 2.83 | 2.83 |
| 501.45 | 4.47 | 4.47 |
| 443.38 | 5.33 | 5.33 |
| 455.41 | 3.74 | 3.74 |
| 337.42 | 3.18 | 3.18 |
| 455.41 | 3.74 | 3.74 |
| 455.41 | 3.74 | 3.74 |
| 444.37 | 4.04 | 4.04 |
| 408.93 | 4.68 | 4.68 |
| 467.42 | 3.59 | 3.59 |
| 362.47 | 3.95 | 3.95 |
| 402.54 | 4.64 | 4.64 |
| 441.38 | 3.35 | 3.35 |
| 406.94 | 2.69 | 2.69 |
| 409.91 | 4.02 | 4.02 |
| 424.93 | 2.83 | 2.83 |
| 365.48 | 3.11 | 3.11 |
| 472.42 | 4.53 | 4.53 |
| 444.36 | 4.49 | 4.49 |
| 444.36 | 4.49 | 4.49 |
| 481.45 | 4.13 | 4.13 |
| 469.43 | 4.08 | 4.08 |
| 442.49 | 5.04 | 5.04 |
| 455.41 | 3.86 | 3.86 |
| 443.38 | 4.65 | 4.65 |
| 335.40 | 3.50 | 3.50 |
| 336.44 | 3.79 | 3.79 |
| 477.37 | 4.44 | 4.44 |
| 486.45 | 4.87 | 4.87 |
| 374.49 | 4.02 | 4.02 |
| 361.44 | 3.31 | 3.31 |
| 442.36 | 3.51 | 3.51 |
| 456.40 | 3.11 | 3.11 |
| 366.47 | 2.65 | 2.65 |
| 372.49 | 2.04 | 2.04 |
| 459.38 | 4.30 | 4.30 |
| 400.53 | 4.59 | 4.59 |
| 481.45 | 3.94 | 3.94 |
| 489.85 | 4.39 | 4.39 |
| 378.52 | 4.31 | 4.31 |
| 357.48 | 3.23 | 3.23 |
| 513.49 | 4.10 | 4.10 |
| 364.44 | 3.78 | 3.78 |
| 426.37 | 4.54 | 4.54 |
| 360.46 | 3.72 | 3.72 |
| 427.35 | 3.78 | 3.78 |
| 499.46 | 3.49 | 3.49 |
| 455.41 | 3.69 | 3.69 |
| 304.39 | 3.70 | 3.70 |
| 375.47 | 3.32 | 3.32 |
| 358.46 | 2.47 | 2.47 |
| 455.41 | 3.74 | 3.74 |