Basic Information
ID: ALA3863193
Type: Binding
Description: Inhibition of human BRD4 bromodomain 1 expressed in Escherichia coli BL21(DE3)-R3-pRARE2 assessed as change in melting temperature at 10 uM by SYPRO orange dye-based differential scanning fluorimetry
Organism: Homo sapiens
Activity Charts
Bioactivity
Activity Types for Assay ALA3863193
Delta Tm
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 424.54 | 3.82 | 3.82 |
| 383.44 | 2.99 | 2.99 |
| 443.97 | 5.33 | 5.33 |
| 399.44 | 3.29 | 3.29 |
| 342.40 | 3.10 | 3.10 |
| 345.42 | 2.53 | 2.53 |
| 377.82 | 3.99 | 3.99 |
| 355.43 | 3.75 | 3.75 |
| 327.38 | 3.11 | 3.11 |
| 429.94 | 5.09 | 5.09 |
| 409.48 | 3.66 | 3.66 |
| 392.28 | 4.80 | 4.80 |
| 436.55 | 3.82 | 3.82 |
| 375.85 | 4.16 | 4.16 |
| 367.45 | 3.89 | 3.89 |
| 379.48 | 4.71 | 4.71 |
| 399.51 | 4.22 | 4.22 |
| 424.52 | 4.26 | 4.26 |
| 393.27 | 4.20 | 4.20 |
| 429.82 | 4.70 | 4.70 |
| 468.59 | 4.22 | 4.22 |
| 438.57 | 4.21 | 4.21 |
| 359.85 | 4.39 | 4.39 |
| 417.89 | 3.92 | 3.92 |
| 383.44 | 3.27 | 3.27 |
| 383.44 | 3.51 | 3.51 |
| 340.38 | 1.87 | 1.87 |
| 365.48 | 3.23 | 3.23 |
| 375.85 | 4.16 | 4.16 |
| 367.45 | 3.89 | 3.89 |
| 410.51 | 3.43 | 3.43 |
| 353.42 | 3.50 | 3.50 |
| 354.41 | 2.90 | 2.90 |
| 387.50 | 4.22 | 4.22 |
| 441.96 | 5.09 | 5.09 |
| 381.47 | 4.12 | 4.12 |
| 341.41 | 3.50 | 3.50 |
| 339.39 | 3.20 | 3.20 |
| 481.59 | 3.33 | 3.33 |
| 353.42 | 2.90 | 2.90 |
| 357.41 | 2.74 | 2.74 |
| 289.33 | 2.03 | 2.03 |
| 403.93 | 4.87 | 4.87 |
| 366.46 | 3.56 | 3.56 |
| 357.41 | 3.12 | 3.12 |
| 385.46 | 3.76 | 3.76 |
| 467.57 | 2.98 | 2.98 |
| 383.44 | 3.51 | 3.51 |
| 381.43 | 3.31 | 3.31 |
| 401.89 | 4.55 | 4.55 |
| 331.80 | 3.76 | 3.76 |
| 339.44 | 4.05 | 4.05 |
| 399.44 | 3.29 | 3.29 |
| 345.83 | 4.15 | 4.15 |
| 390.87 | 3.90 | 3.90 |
| 383.49 | 4.53 | 4.53 |
| 483.61 | 3.57 | 3.57 |
| 391.92 | 4.96 | 4.96 |
| 455.00 | 4.86 | 4.86 |
| 383.49 | 4.53 | 4.53 |
| 357.84 | 4.15 | 4.15 |
| 387.86 | 4.16 | 4.16 |
| 377.82 | 2.74 | 2.74 |
| 455.56 | 2.79 | 2.79 |
| 495.62 | 3.72 | 3.72 |
| 337.42 | 3.80 | 3.80 |
| 481.59 | 3.33 | 3.33 |
| 467.57 | 2.98 | 2.98 |
| 440.61 | 4.58 | 4.58 |
| 367.45 | 3.81 | 3.81 |
| 359.37 | 3.77 | 3.77 |
| 393.84 | 4.10 | 4.10 |
| 480.61 | 4.22 | 4.22 |
| 444.55 | 3.56 | 3.56 |
| 385.42 | 3.20 | 3.20 |
| 423.51 | 3.94 | 3.94 |
| 383.44 | 3.51 | 3.51 |
| 348.40 | 3.36 | 3.36 |
| 427.95 | 5.78 | 5.78 |
| 387.86 | 4.16 | 4.16 |
| 388.90 | 3.38 | 3.38 |
| 450.58 | 4.21 | 4.21 |
| 532.08 | 3.72 | 3.72 |
| 477.63 | 4.81 | 4.81 |
| 415.80 | 4.31 | 4.31 |
| 392.91 | 3.72 | 3.72 |
| 439.96 | 5.78 | 5.78 |
| 422.53 | 3.58 | 3.58 |
| 362.81 | 3.30 | 3.30 |
| 371.86 | 4.54 | 4.54 |
| 410.47 | 3.48 | 3.48 |
| 385.42 | 3.20 | 3.20 |
| 371.46 | 3.76 | 3.76 |
| 382.42 | 3.71 | 3.71 |
| 367.40 | 3.22 | 3.22 |
| 369.49 | 4.22 | 4.22 |