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ID: ALA3867373
Type: ADME
Description: Inhibition of recombinant human DHFR expressed in Escherichia coli preincubated for 15 mins followed by addition of DHF as substrate and NADPH measured after 60 mins by resazurin/diaphorase coupled assay
Format: BAO_0000019
Organism: Homo sapiens
Target: Dihydrofolate reductase(ALA202)
Document: ALA3865850
Inhibition of recombinant human DHFR expressed in Escherichia coli preincubated for 15 mins followed by addition of DHF as substrate and NADPH measured after 60 mins by resazurin/diaphorase coupled assay: 1
Bioactivity
Activity Types for Assay ALA3867373
IC50
Parent Molecular Weight | ALogP | Polar Surface Area |
---|---|---|
248.72 | 2.52 | 2.52 |
454.45 | 0.27 | 0.27 |
394.40 | 2.01 | 2.01 |
293.16 | 3.52 | 3.52 |
399.50 | 2.81 | 2.81 |
273.73 | 2.45 | 2.45 |
265.32 | 2.67 | 2.67 |
409.93 | 2.99 | 2.99 |
374.49 | 2.94 | 2.94 |
352.35 | 2.98 | 2.98 |
352.36 | 1.98 | 1.98 |
279.13 | 3.51 | 3.51 |
366.34 | 4.02 | 4.02 |
413.49 | 2.45 | 2.45 |
350.81 | 3.36 | 3.36 |
423.91 | 2.63 | 2.63 |
339.23 | 2.27 | 2.27 |
346.44 | 2.63 | 2.63 |
388.48 | 2.58 | 2.58 |
260.68 | 2.15 | 2.15 |
383.38 | 4.33 | 4.33 |
383.38 | 4.33 | 4.33 |
492.93 | 4.21 | 4.21 |
279.35 | 2.68 | 2.68 |