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Inhibition of recombinant human DHFR expressed in Escherichia coli preincubated for 15 mins followed by addition of DHF as substrate and NADPH measure...

Basic Information

ID: ALA3867373

Type: ADME

Description: Inhibition of recombinant human DHFR expressed in Escherichia coli preincubated for 15 mins followed by addition of DHF as substrate and NADPH measured after 60 mins by resazurin/diaphorase coupled assay

Format: BAO_0000019

Organism: Homo sapiens

Target:  Dihydrofolate reductase(ALA202)

Document:  ALA3865850

Inhibition of recombinant human DHFR expressed in Escherichia coli preincubated for 15 mins followed by addition of DHF as substrate and NADPH measured after 60 mins by resazurin/diaphorase coupled assay: 1

Activity Charts

Compound Summary

Parent Molecular WeightALogPPolar Surface Area
248.722.522.52
454.450.270.27
394.402.012.01
293.163.523.52
399.502.812.81
273.732.452.45
265.322.672.67
409.932.992.99
374.492.942.94
352.352.982.98
352.361.981.98
279.133.513.51
366.344.024.02
413.492.452.45
350.813.363.36
423.912.632.63
339.232.272.27
346.442.632.63
388.482.582.58
260.682.152.15
383.384.334.33
383.384.334.33
492.934.214.21
279.352.682.68