Basic Information
ID: ALA3871972
Type: Binding
Description: Inhibition of N-terminal His6-tagged DNMT3A (623 to 908 residues) (unknown origin) expressed in Escherichia coli BL21 (DE3) coexpressing DNMT3L (160 to 386 C-terminal residues) (unknown origin) assessed as reduction in oligonucleosome methylation preincubated for 15 mins followed by addition of [3H]-SAM measured after 4 hrs by liquid scintillation counting method
Organism: Homo sapiens
Activity Charts
Bioactivity
Activity Types for Assay ALA3871972
IC50
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 376.37 | 3.34 | 3.34 |
| 387.40 | 3.14 | 3.14 |
| 402.41 | 3.76 | 3.76 |
| 493.31 | 4.76 | 4.76 |
| 388.38 | 3.45 | 3.45 |
| 366.37 | 3.03 | 3.03 |
| 387.40 | 3.14 | 3.14 |
| 447.24 | 2.64 | 2.64 |
| 403.19 | 2.63 | 2.63 |
| 390.35 | 3.03 | 3.03 |
| 417.22 | 3.02 | 3.02 |
| 386.41 | 4.14 | 4.14 |
| 509.31 | 4.60 | 4.60 |
| 380.79 | 3.98 | 3.98 |
| 543.71 | 4.55 | 4.55 |
| 415.29 | 4.26 | 4.26 |