Basic Information
ID: ALA3873578
Type: Binding
Description: Inhibition of mPGES-1 in human A549 cells assessed as reduction in interleukin-1 beta-induced PGE2 production incubated for 30 mins followed by IL-1beta stimulation for 16 to 20 hrs in presence of 2% fetal bovine serum by HTRF assay
Organism: Homo sapiens
Cell type: A549
Activity Charts
Bioactivity
Activity Types for Assay ALA3873578
IC50
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 378.82 | 5.93 | 5.93 |
| 499.86 | 6.92 | 6.92 |
| 520.87 | 6.45 | 6.45 |
| 538.86 | 6.29 | 6.29 |
| 538.86 | 6.29 | 6.29 |
| 513.88 | 6.93 | 6.93 |
| 506.84 | 6.14 | 6.14 |
| 520.92 | 6.02 | 6.02 |
| 512.82 | 5.93 | 5.93 |
| 503.92 | 5.28 | 5.28 |
| 524.83 | 6.28 | 6.28 |
| 520.87 | 6.15 | 6.15 |
| 524.83 | 6.28 | 6.28 |
| 499.96 | 5.45 | 5.45 |
| 520.87 | 6.15 | 6.15 |
| 538.86 | 5.96 | 5.96 |
| 552.89 | 6.77 | 6.77 |
| 506.84 | 6.14 | 6.14 |
| 534.95 | 6.03 | 6.03 |
| 526.92 | 5.97 | 5.97 |
| 540.88 | 6.54 | 6.54 |
| 517.95 | 5.29 | 5.29 |
| 472.95 | 5.57 | 5.57 |
| 508.93 | 5.89 | 5.89 |
| 552.89 | 5.97 | 5.97 |
| 540.95 | 5.98 | 5.98 |
| 486.98 | 5.58 | 5.58 |
| 526.92 | 5.73 | 5.73 |