Basic Information
ID: ALA3875507
Type: Binding
Description: Inhibition of MLL1-WDR5 protein-protein interaction in human MV4-11 cells harboring MLL-AF4 fusion protein assessed as inhibition of MLL1 histone methyltransferase activity by measuring reduction in H3K4me1 level at 10 uM after 7 days by Western blot method
Format: BAO_0000219
Organism: Homo sapiens
Cell type: MV4-11
Target: Histone-lysine N-methyltransferase 2A/WDR5(ALA3883320)
Document: ALA3875159
Inhibition of MLL1-WDR5 protein-protein interaction in human MV4-11 cells harboring MLL-AF4 fusion protein assessed as inhibition of MLL1 histone methyltransferase activity by measuring reduction in H3K4me1 level at 10 uM after 7 days by Western blot method: 1
Activity Charts
Bioactivity
Activity Types for Assay ALA3875507
Inhibition
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 669.82 | 3.68 | 3.68 |