Basic Information
ID: ALA3878759
Type: Binding
Description: Inhibition of TSPO in mouse HT22 cells assessed as protection against amyloid beta (1 to 42)-induced mitochondrial membrane potential loss by measuring recovery of mitochondrial membrane potential at 5 uM preincubated for 10 mins followed by amyloid beta (1 to 42) addition measured every 1 hr for 3 hrs by JC1 staining based fluorescence assay relative to control
Organism: Mus musculus
Cell type: HT-22
Activity Charts
Bioactivity
Activity Types for Assay ALA3878759
Activity
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 142.16 | -0.91 | -0.91 |
| 1202.63 | ||
| 492.60 | 5.00 | 5.00 |
| 383.50 | 5.77 | 5.77 |
| 460.58 | 5.54 | 5.54 |
| 452.39 | 7.08 | 7.08 |
| 363.46 | 5.22 | 5.22 |
| 522.52 | 8.17 | 8.17 |
| 486.83 | 7.73 | 7.73 |
| 513.68 | 6.88 | 6.88 |
| 550.53 | 5.35 | 5.35 |
| 500.60 | 5.87 | 5.87 |
| 573.62 | 7.96 | 7.96 |
| 470.36 | 5.59 | 5.59 |
| 462.54 | 5.53 | 5.53 |
| 521.49 | 6.20 | 6.20 |
| 505.66 | 5.37 | 5.37 |
| 521.49 | 6.20 | 6.20 |
| 521.49 | 6.20 | 6.20 |
| 397.52 | 5.95 | 5.95 |
| 525.70 | 5.38 | 5.38 |
| 414.55 | 5.50 | 5.50 |
| 466.41 | 7.00 | 7.00 |
| 535.52 | 6.59 | 6.59 |
| 465.17 | 6.96 | 6.96 |
| 399.54 | 5.12 | 5.12 |
| 499.61 | 7.61 | 7.61 |
| 499.61 | 7.61 | 7.61 |
| 486.83 | 7.73 | 7.73 |
| 457.57 | 5.71 | 5.71 |
| 537.49 | 5.43 | 5.43 |
| 527.60 | 7.86 | 7.86 |
| 478.57 | 4.70 | 4.70 |
| 495.45 | 5.66 | 5.66 |
| 466.41 | 7.00 | 7.00 |
| 503.65 | 5.13 | 5.13 |
| 507.47 | 5.81 | 5.81 |
| 453.63 | 6.86 | 6.86 |
| 443.55 | 5.79 | 5.79 |
| 432.52 | 5.08 | 5.08 |
| 438.36 | 5.68 | 5.68 |
| 503.65 | 5.13 | 5.13 |
| 396.28 | 5.65 | 5.65 |
| 446.58 | 5.63 | 5.63 |
| 565.76 | 6.30 | 6.30 |
| 466.41 | 7.25 | 7.25 |
| 439.60 | 6.94 | 6.94 |
| 516.67 | 6.34 | 6.34 |
| 451.52 | 4.69 | 4.69 |
| 411.55 | 5.87 | 5.87 |
| 440.93 | 5.46 | 5.46 |
| 436.47 | 4.23 | 4.23 |
| 476.67 | 5.64 | 5.64 |
| 397.52 | 5.70 | 5.70 |
| 416.98 | 5.03 | 5.03 |
| 504.73 | 6.34 | 6.34 |
| 393.85 | 5.52 | 5.52 |
| 551.74 | 5.91 | 5.91 |
| 505.62 | 3.97 | 3.97 |