Basic Information
ID: ALA3879995
Type: ADME
Description: Therapeutic index, ratio of neurotoxicity in iv dosed Sprague-Dawley rat assessed as total amount of drug infused at the point that partial or complete convulsions are first observed to 20 times ED50 for antiarrhythmic activity in iv dosed Sprague-Dawley rat coronary artery occlusion model
Organism: Rattus norvegicus
Strain: Sprague-Dawley
Tissue: Coronary artery
Activity Charts
Bioactivity
Activity Types for Assay ALA3879995
TI
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 385.93 | 2.64 | 2.64 |
| 365.90 | 3.37 | 3.37 |
| 398.98 | 2.87 | 2.87 |
| 413.99 | 3.69 | 3.69 |
| 563.14 | 3.98 | 3.98 |
| 375.94 | 3.78 | 3.78 |
| 385.93 | 2.64 | 2.64 |
| 393.88 | 3.91 | 3.91 |
| 385.93 | 2.64 | 2.64 |
| 476.06 | 4.87 | 4.87 |
| 427.97 | 3.21 | 3.21 |
| 396.81 | 4.87 | 4.87 |
| 339.48 | 4.04 | 4.04 |
| 427.97 | 3.21 | 3.21 |
| 399.96 | 4.42 | 4.42 |
| 358.31 | 4.20 | 4.20 |
| 385.93 | 2.64 | 2.64 |
| 392.75 | 4.14 | 4.14 |
| 385.93 | 2.64 | 2.64 |
| 404.78 | 3.39 | 3.39 |
| 368.31 | 3.65 | 3.65 |
| 383.92 | 2.85 | 2.85 |
| 380.74 | 4.15 | 4.15 |
| 417.98 | 4.35 | 4.35 |
| 394.77 | 3.93 | 3.93 |
| 349.47 | 2.91 | 2.91 |
| 345.51 | 4.10 | 4.10 |
| 364.92 | 3.04 | 3.04 |
| 368.31 | 3.65 | 3.65 |
| 393.88 | 3.64 | 3.64 |
| 385.93 | 2.64 | 2.64 |
| 385.93 | 2.64 | 2.64 |
| 387.92 | 3.62 | 3.62 |
| 339.48 | 4.04 | 4.04 |
| 355.48 | 3.88 | 3.88 |
| 384.31 | 3.49 | 3.49 |
| 399.96 | 3.03 | 3.03 |
| 427.97 | 3.02 | 3.02 |
| 434.40 | 3.68 | 3.68 |
| 345.51 | 4.10 | 4.10 |
| 369.93 | 3.67 | 3.67 |
| 378.73 | 4.10 | 4.10 |
| 385.93 | 2.91 | 2.91 |
| 368.31 | 3.65 | 3.65 |
| 476.06 | 4.87 | 4.87 |