Basic Information
ID: ALA3880153
Type: Functional
Description: Cytotoxicity against human A375 cells expressing B-RAF V600E mutant assessed as growth inhibition after 3 days by ATPlite 1 step luminescence assay
Organism: Homo sapiens
Cell type: A-375
Activity Charts
Bioactivity
Activity Types for Assay ALA3880153
IC50
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 439.40 | 3.14 | 3.14 |
| 474.39 | 4.02 | 4.02 |
| 558.61 | 4.01 | 4.01 |
| 448.84 | 3.92 | 3.92 |
| 539.50 | 4.48 | 4.48 |
| 599.66 | 4.39 | 4.39 |
| 483.83 | 4.80 | 4.80 |
| 471.49 | 3.87 | 3.87 |
| 498.56 | 5.24 | 5.24 |
| 471.49 | 3.99 | 3.99 |
| 465.84 | 4.67 | 4.67 |
| 547.61 | 4.68 | 4.68 |
| 461.42 | 4.02 | 4.02 |
| 513.53 | 4.24 | 4.24 |
| 548.59 | 3.80 | 3.80 |
| 463.41 | 4.46 | 4.46 |
| 557.49 | 4.62 | 4.62 |
| 534.57 | 3.54 | 3.54 |
| 574.63 | 4.33 | 4.33 |
| 473.51 | 3.87 | 3.87 |
| 499.50 | 3.38 | 3.38 |
| 517.51 | 3.70 | 3.70 |
| 490.92 | 4.94 | 4.94 |
| 535.58 | 5.14 | 5.14 |
| 444.42 | 3.28 | 3.28 |
| 438.42 | 3.74 | 3.74 |
| 585.63 | 4.00 | 4.00 |
| 469.50 | 3.55 | 3.55 |
| 483.83 | 4.80 | 4.80 |
| 512.54 | 4.85 | 4.85 |
| 438.42 | 3.74 | 3.74 |
| 525.58 | 4.89 | 4.89 |
| 474.46 | 4.42 | 4.42 |
| 457.46 | 3.68 | 3.68 |
| 482.54 | 3.61 | 3.61 |
| 474.39 | 4.02 | 4.02 |
| 526.57 | 4.28 | 4.28 |
| 527.55 | 4.04 | 4.04 |
| 483.83 | 4.80 | 4.80 |
| 420.43 | 3.61 | 3.61 |
| 502.57 | 5.01 | 5.01 |
| 470.50 | 4.59 | 4.59 |
| 456.40 | 3.88 | 3.88 |
| 562.62 | 4.14 | 4.14 |
| 533.58 | 4.29 | 4.29 |
| 445.42 | 4.32 | 4.32 |
| 557.49 | 4.62 | 4.62 |
| 583.66 | 5.15 | 5.15 |
| 456.40 | 3.88 | 3.88 |
| 500.53 | 3.75 | 3.75 |
| 539.50 | 4.48 | 4.48 |
| 456.40 | 3.88 | 3.88 |
| 542.57 | 3.52 | 3.52 |
| 447.46 | 3.22 | 3.22 |
| 403.41 | 3.21 | 3.21 |
| 445.42 | 4.32 | 4.32 |
| 479.41 | 4.16 | 4.16 |
| 565.65 | 4.98 | 4.98 |
| 461.42 | 4.02 | 4.02 |
| 558.61 | 3.42 | 3.42 |
| 456.40 | 3.88 | 3.88 |
| 557.62 | 4.62 | 4.62 |
| 499.54 | 4.35 | 4.35 |
| 461.42 | 4.02 | 4.02 |
| 488.49 | 4.73 | 4.73 |
| 438.42 | 3.74 | 3.74 |
| 479.41 | 4.16 | 4.16 |
| 569.63 | 4.76 | 4.76 |
| 472.47 | 3.99 | 3.99 |
| 474.46 | 4.42 | 4.42 |
| 479.41 | 4.16 | 4.16 |
| 439.40 | 3.14 | 3.14 |
| 534.57 | 3.69 | 3.69 |
| 448.84 | 3.92 | 3.92 |
| 445.45 | 3.61 | 3.61 |
| 474.39 | 4.02 | 4.02 |
| 539.56 | 4.18 | 4.18 |
| 483.83 | 4.80 | 4.80 |
| 513.53 | 3.65 | 3.65 |
| 428.42 | 3.58 | 3.58 |
| 516.53 | 4.30 | 4.30 |
| 548.59 | 4.26 | 4.26 |
| 456.40 | 3.88 | 3.88 |
| 421.41 | 3.00 | 3.00 |
| 465.84 | 4.67 | 4.67 |
| 533.58 | 4.29 | 4.29 |
| 604.66 | 3.91 | 3.91 |
| 503.56 | 4.40 | 4.40 |
| 527.59 | 5.47 | 5.47 |
| 463.41 | 4.46 | 4.46 |