Basic Information
ID: ALA3880354
Type: Binding
Description: Inhibition of recombinant human NAEalpha/N-terminal His-tagged NAEbeta expressed in baculovirus infected insect Sf9 cells using N-terminal FLAG tagged Nedd8 as substrate incubated for 105 mins in presence of N-terminal GST-tagged Ubc12 by FRET assay
Format: BAO_0000219
Organism: Homo sapiens
Cell type: Sf9
Target: NEDD8 activating enzyme(ALA3831283)
Document: ALA3879911
Inhibition of recombinant human NAEalpha/N-terminal His-tagged NAEbeta expressed in baculovirus infected insect Sf9 cells using N-terminal FLAG tagged Nedd8 as substrate incubated for 105 mins in presence of N-terminal GST-tagged Ubc12 by FRET assay: 38
Activity Charts
Bioactivity
Activity Types for Assay ALA3880354
IC50
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 471.49 | 0.60 | 0.60 |
| 469.95 | 0.97 | 0.97 |
| 419.51 | 1.35 | 1.35 |
| 474.54 | 1.50 | 1.50 |
| 331.35 | -1.86 | -1.86 |
| 487.97 | 3.20 | 3.20 |
| 435.51 | 0.32 | 0.32 |
| 447.56 | 2.08 | 2.08 |
| 423.50 | -0.14 | -0.14 |
| 418.48 | 0.80 | 0.80 |
| 497.58 | 2.01 | 2.01 |
| 331.35 | -1.86 | -1.86 |
| 449.53 | 0.63 | 0.63 |
| 418.48 | 0.72 | 0.72 |
| 405.44 | 1.06 | 1.06 |
| 465.53 | -0.06 | -0.06 |
| 462.49 | 0.56 | 0.56 |
| 451.50 | 0.91 | 0.91 |
| 483.53 | 0.23 | 0.23 |
| 344.35 | -1.90 | -1.90 |
| 451.50 | 0.91 | 0.91 |
| 482.00 | 3.31 | 3.31 |
| 469.95 | 0.97 | 0.97 |
| 468.54 | 1.97 | 1.97 |
| 438.90 | 1.44 | 1.44 |
| 419.51 | 1.35 | 1.35 |
| 510.58 | 2.37 | 2.37 |
| 453.50 | 0.46 | 0.46 |
| 451.50 | 0.91 | 0.91 |
| 463.56 | 1.05 | 1.05 |
| 289.31 | -0.78 | -0.78 |
| 449.53 | 0.34 | 0.34 |
| 455.50 | 1.34 | 1.34 |
| 423.50 | -0.14 | -0.14 |
| 510.58 | 2.37 | 2.37 |
| 480.55 | 2.46 | 2.46 |
| 434.52 | 1.70 | 1.70 |
| 498.57 | 1.98 | 1.98 |
| 449.53 | 0.97 | 0.97 |
| 468.51 | 1.08 | 1.08 |
| 435.51 | 0.64 | 0.64 |
| 379.46 | 2.44 | 2.44 |
| 423.50 | 0.14 | 0.14 |
| 415.52 | 0.21 | 0.21 |
| 454.51 | 2.52 | 2.52 |
| 471.49 | 0.60 | 0.60 |
| 449.53 | 0.51 | 0.51 |
| 456.48 | 1.31 | 1.31 |
| 434.52 | 1.62 | 1.62 |
| 449.53 | 0.88 | 0.88 |
| 488.45 | 1.69 | 1.69 |
| 331.35 | -1.86 | -1.86 |
| 493.59 | 0.77 | 0.77 |
| 451.50 | 0.91 | 0.91 |
| 463.56 | 1.05 | 1.05 |
| 434.48 | 0.80 | 0.80 |
| 415.52 | 0.21 | 0.21 |
| 444.51 | 1.98 | 1.98 |
| 420.49 | 0.78 | 0.78 |
| 420.45 | -0.24 | -0.24 |
| 436.49 | -0.29 | -0.29 |
| 466.52 | -0.66 | -0.66 |
| 455.50 | 1.91 | 1.91 |
| 434.52 | 1.56 | 1.56 |
| 435.51 | 0.32 | 0.32 |
| 454.51 | 1.94 | 1.94 |
| 333.37 | -1.89 | -1.89 |
| 408.48 | 0.00 | 0.00 |
| 404.45 | 0.79 | 0.79 |
| 419.51 | 1.35 | 1.35 |
| 477.59 | 1.10 | 1.10 |
| 449.53 | 0.71 | 0.71 |
| 464.50 | 0.81 | 0.81 |
| 432.51 | 1.41 | 1.41 |
| 409.47 | -0.17 | -0.17 |
| 496.55 | 2.58 | 2.58 |
| 419.50 | 1.92 | 1.92 |
| 491.57 | 0.63 | 0.63 |
| 450.52 | 0.02 | 0.02 |
| 465.55 | 2.22 | 2.22 |
| 490.93 | 1.96 | 1.96 |
| 435.51 | 0.32 | 0.32 |
| 480.55 | 2.46 | 2.46 |
| 494.53 | 2.69 | 2.69 |
| 453.52 | 2.55 | 2.55 |
| 403.46 | 1.40 | 1.40 |
| 419.51 | 1.35 | 1.35 |
| 438.90 | 1.44 | 1.44 |
| 418.52 | 1.73 | 1.73 |
| 493.59 | 0.77 | 0.77 |
| 419.46 | 0.61 | 0.61 |
| 404.45 | -0.38 | -0.38 |
| 418.48 | 1.10 | 1.10 |
| 453.50 | 0.46 | 0.46 |
| 438.90 | 1.44 | 1.44 |
| 409.47 | -0.17 | -0.17 |
| 405.44 | 0.76 | 0.76 |
| 392.48 | 1.03 | 1.03 |
| 429.88 | 1.45 | 1.45 |
| 420.49 | 1.31 | 1.31 |