Basic Information
ID: ALA3880373
Type: Binding
Description: Antagonist activity at recombinant human N-terminal signal peptide/FLAG epitope-tagged Rluc8-fused VIPR2 expressed in HEK293 cells assessed as inhibition of VIP-induced human mVenus-beta-arrestin2 binding at 5 uM preincubated for 5 mins with luciferin, coelenterazine H followed by VIP addition measured after 5 mins by BRET assay relative to control
Format: BAO_0000219
Organism: Homo sapiens
Cell type: HEK293
Target: Vasoactive intestinal polypeptide receptor 2(ALA4532)
Document: ALA3879914
Antagonist activity at recombinant human N-terminal signal peptide/FLAG epitope-tagged Rluc8-fused VIPR2 expressed in HEK293 cells assessed as inhibition of VIP-induced human mVenus-beta-arrestin2 binding at 5 uM preincubated for 5 mins with luciferin, coelenterazine H followed by VIP addition measured after 5 mins by BRET assay relative to control: 38
Activity Charts
Bioactivity
Activity Types for Assay ALA3880373
Inhibition
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 445.50 | 1.23 | 1.23 |
| 577.70 | 2.70 | 2.70 |
| 463.56 | 2.35 | 2.35 |
| 553.64 | 2.57 | 2.57 |
| 538.62 | 2.05 | 2.05 |
| 475.57 | 2.50 | 2.50 |
| 508.62 | 3.95 | 3.95 |
| 607.73 | 1.82 | 1.82 |
| 354.45 | 1.33 | 1.33 |
| 475.57 | 2.50 | 2.50 |
| 503.62 | 3.18 | 3.18 |
| 593.75 | 2.88 | 2.88 |
| 565.74 | 3.42 | 3.42 |
| 505.57 | 0.80 | 0.80 |
| 551.71 | 3.17 | 3.17 |
| 465.38 | 2.29 | 2.29 |
| 522.67 | 2.97 | 2.97 |
| 422.53 | 1.90 | 1.90 |
| 503.62 | 3.18 | 3.18 |
| 620.86 | 5.72 | 5.72 |
| 550.72 | 3.65 | 3.65 |
| 523.66 | 2.39 | 2.39 |
| 523.61 | 2.77 | 2.77 |
| 635.74 | 3.45 | 3.45 |
| 430.93 | 1.73 | 1.73 |
| 551.67 | 1.71 | 1.71 |
| 458.99 | 2.51 | 2.51 |
| 593.75 | 2.83 | 2.83 |
| 432.54 | 0.92 | 0.92 |
| 507.03 | 3.54 | 3.54 |
| 474.62 | 1.95 | 1.95 |
| 551.71 | 3.17 | 3.17 |
| 477.54 | 1.34 | 1.34 |
| 459.55 | 2.20 | 2.20 |
| 505.64 | 3.42 | 3.42 |
| 537.68 | 2.42 | 2.42 |
| 477.54 | 1.34 | 1.34 |
| 463.56 | 2.40 | 2.40 |
| 565.69 | 2.70 | 2.70 |
| 512.60 | 2.49 | 2.49 |
| 445.50 | 1.23 | 1.23 |
| 478.63 | 3.46 | 3.46 |
| 579.72 | 2.94 | 2.94 |
| 497.57 | 2.80 | 2.80 |
| 448.52 | 2.39 | 2.39 |
| 567.66 | 3.25 | 3.25 |
| 421.48 | 1.23 | 1.23 |
| 505.59 | 1.71 | 1.71 |
| 497.57 | 2.80 | 2.80 |
| 537.45 | 3.56 | 3.56 |
| 551.67 | 2.31 | 2.31 |
| 546.05 | 3.50 | 3.50 |
| 579.76 | 3.95 | 3.95 |
| 448.56 | 2.29 | 2.29 |
| 553.64 | 2.91 | 2.91 |
| 463.56 | 2.35 | 2.35 |
| 490.58 | 2.00 | 2.00 |
| 517.46 | 3.05 | 3.05 |
| 605.76 | 2.98 | 2.98 |
| 508.64 | 2.66 | 2.66 |
| 490.58 | 2.00 | 2.00 |
| 503.62 | 3.32 | 3.32 |
| 546.05 | 3.50 | 3.50 |
| 503.62 | 3.32 | 3.32 |
| 537.64 | 3.68 | 3.68 |
| 435.50 | 1.62 | 1.62 |
| 593.70 | 2.88 | 2.88 |
| 533.55 | 3.08 | 3.08 |
| 507.03 | 3.38 | 3.38 |
| 459.55 | 2.20 | 2.20 |
| 548.64 | 2.83 | 2.83 |
| 557.11 | 3.62 | 3.62 |
| 475.57 | 2.54 | 2.54 |
| 475.57 | 2.54 | 2.54 |
| 459.55 | 2.20 | 2.20 |
| 424.54 | 2.14 | 2.14 |
| 605.76 | 3.02 | 3.02 |
| 536.69 | 3.47 | 3.47 |
| 562.61 | 3.37 | 3.37 |
| 463.56 | 2.40 | 2.40 |
| 505.64 | 3.42 | 3.42 |
| 536.65 | 2.55 | 2.55 |
| 514.67 | 4.10 | 4.10 |
| 484.60 | 3.44 | 3.44 |
| 539.61 | 2.26 | 2.26 |
| 503.56 | 2.71 | 2.71 |
| 561.89 | 4.76 | 4.76 |
| 503.56 | 2.71 | 2.71 |
| 627.76 | 3.28 | 3.28 |
| 519.62 | 2.22 | 2.22 |
| 554.67 | 2.37 | 2.37 |
| 435.50 | 1.62 | 1.62 |
| 539.61 | 2.26 | 2.26 |
| 503.56 | 2.71 | 2.71 |
| 562.61 | 3.37 | 3.37 |
| 533.55 | 3.08 | 3.08 |
| 407.45 | 0.97 | 0.97 |
| 509.63 | 1.93 | 1.93 |
| 537.64 | 3.68 | 3.68 |
| 407.45 | 0.97 | 0.97 |