Assay Report Card

Basic Information

ID: ALA3880377

Type: Binding

Description: Inhibition of recombinant human fetal brain FLAG-tagged PRMT5/full length human testis 6His-tagged MEP50 expressed in baculovirus infected insect Sf9 cells using human histone H4 (1 to 15 residues) as substrate preincubated for 30 mins followed by [3H]-SAM addition

Organism: Homo sapiens

Cell type: Sf9

Activity Charts

Compound Summary

Parent Molecular WeightALogPPolar Surface Area
331.843.283.28
297.402.622.62
327.382.212.21
355.432.262.26
394.481.491.49
366.512.952.95
402.493.253.25
380.491.151.15
409.531.681.68
469.594.414.41
394.481.491.49
418.493.333.33
387.482.902.90
380.533.523.52
437.563.563.56
422.571.581.58
379.501.911.91
461.915.825.82
437.582.842.84
397.481.561.56
413.533.473.47
387.482.902.90
410.521.821.82
331.420.100.10
420.512.492.49
414.513.433.43
477.612.222.22
416.532.302.30
318.461.911.91
378.453.693.69
338.411.831.83
356.430.580.58
418.521.001.00
391.472.952.95
453.541.071.07
441.584.994.99
403.501.211.21
370.451.611.61
387.482.902.90
437.541.511.51
275.392.362.36
443.554.054.05
355.441.131.13
455.562.952.95
377.464.294.29
391.494.604.60
364.492.812.81
390.482.752.75
455.563.503.50
373.504.084.08
409.572.812.81
482.634.434.43
354.451.991.99
398.461.371.37
413.524.044.04
340.421.601.60
427.554.604.60
469.581.311.31
391.472.502.50
434.520.370.37
358.411.741.74
378.453.693.69
527.632.762.76
413.524.044.04
447.560.850.85
389.504.064.06
406.491.991.99
413.524.114.11
384.484.024.02
408.551.241.24
413.524.044.04
427.554.434.43
482.634.384.38
389.503.643.64
447.561.001.00
406.492.472.47
370.451.611.61
377.442.112.11
379.501.751.75
365.431.471.47
393.464.004.00
406.492.472.47
423.511.311.31
383.491.431.43
540.672.102.10
393.914.814.81
418.521.001.00
384.481.061.06
440.541.591.59
404.472.532.53
394.563.913.91
417.513.943.94
394.481.491.49
399.922.412.41
473.574.064.06
406.492.472.47
303.453.003.00
398.460.950.95
473.600.920.92
360.463.553.55
311.381.231.23
433.530.810.81
348.440.720.72
469.594.414.41
396.532.752.75
423.944.814.81
451.570.990.99
412.534.644.64
403.483.133.13
394.481.491.49
398.893.933.93
366.513.473.47
304.431.521.52
495.466.196.19
480.614.444.44
489.590.620.62
427.554.604.60
354.451.911.91
419.522.932.93
469.581.311.31
458.613.303.30
425.531.441.44
422.573.653.65
406.492.472.47
367.451.791.79
454.583.073.07
408.460.840.84
447.974.694.69
420.512.492.49
471.562.642.64
377.442.112.11
377.442.112.11
441.585.085.08
404.513.013.01
339.441.631.63
482.633.813.81
390.522.822.82
410.524.704.70
402.502.792.79
415.502.832.83
374.483.863.86
353.420.930.93
410.512.392.39
411.501.431.43
413.533.473.47
410.563.533.53
406.491.991.99
408.551.821.82
476.581.991.99
443.554.054.05
430.503.483.48
340.421.601.60
524.674.514.51
364.492.812.81
410.524.704.70
325.412.232.23
322.411.991.99
475.595.495.49
413.533.473.47
375.473.013.01
400.484.294.29
432.541.391.39
387.482.902.90
290.360.260.26
451.575.945.94
361.442.942.94
393.442.722.72
340.421.601.60
414.512.862.86
423.944.814.81
449.556.056.05
310.401.841.84
489.625.555.55
413.533.473.47
395.502.382.38
415.502.832.83
366.512.952.95
365.524.534.53
404.472.532.53
366.293.933.93
393.914.814.81
525.663.343.34
449.561.481.48
380.533.473.47
398.514.224.22
312.412.582.58
398.514.064.06
379.502.062.06
414.512.862.86
365.431.471.47
438.571.351.35
540.672.672.67
411.460.930.93
396.532.452.45
468.613.423.42
423.562.022.02
391.472.152.15
298.392.022.02
470.573.453.45
471.572.072.07
490.601.981.98
423.944.814.81
323.442.592.59
411.503.143.14
400.483.423.42
339.441.221.22
410.524.704.70
354.451.911.91
405.502.542.54
408.460.840.84
326.402.192.19
403.483.133.13
394.564.084.08
415.493.323.32
403.501.211.21
358.411.741.74
392.461.951.95
401.514.354.35
414.513.433.43
378.564.074.07
383.491.671.67
425.490.960.96
404.490.960.96
409.531.591.59
414.512.862.86
380.533.523.52
363.504.444.44
413.524.044.04
367.451.791.79
414.512.862.86
420.562.982.98
395.501.251.25
366.513.093.09
435.545.085.08
418.521.001.00
390.522.822.82
502.640.680.68
466.581.271.27
439.562.442.44
377.483.783.78
406.491.991.99
387.482.902.90
327.422.632.63
468.613.463.46
380.491.151.15
407.472.752.75
394.481.491.49
433.530.970.97
324.421.761.76
408.551.591.59
397.481.561.56
488.610.190.19
488.633.283.28
395.501.251.25
427.522.572.57
437.563.563.56
393.491.521.52
427.551.541.54
379.553.553.55
376.502.432.43
374.483.863.86
394.563.913.91
427.551.541.54
330.472.492.49
416.541.721.72
469.594.414.41
409.532.432.43
419.500.250.25
499.614.534.53
395.501.291.29
405.502.542.54
416.524.114.11
395.501.671.67
394.522.482.48
261.361.831.83
421.502.162.16
291.391.601.60
303.453.153.15
373.500.730.73
290.411.031.03
437.582.412.41
445.605.475.47
405.502.542.54
395.502.042.04
352.482.502.50
423.562.102.10
383.471.891.89
389.504.164.16
409.531.981.98
380.533.523.52
489.590.360.36
360.463.553.55
346.471.871.87
367.47-0.49-0.49
394.563.863.86
402.544.224.22
409.532.432.43
382.553.513.51
375.473.863.86
391.513.423.42
425.531.441.44
376.462.232.23
394.564.084.08
378.482.822.82
452.583.523.52
368.482.382.38
437.583.063.06
403.524.204.20
454.573.653.65
394.563.913.91
413.533.473.47
384.484.024.02
407.512.402.40
423.562.452.45
377.464.294.29
417.512.912.91
367.491.891.89
393.532.252.25
525.663.513.51
415.565.375.37
423.562.072.07
419.500.250.25
437.583.213.21
447.974.694.69
395.552.332.33
427.503.683.68
472.593.623.62
394.564.174.17
373.462.862.86
398.460.950.95
519.655.565.56
290.411.171.17
404.472.532.53
411.501.301.30
392.462.462.46
290.411.131.13
418.542.782.78
427.475.175.17
461.915.825.82
394.563.913.91
399.494.004.00
399.494.034.03
403.483.133.13
470.573.253.25
384.481.061.06
454.574.014.01
473.601.391.39
379.502.062.06
414.512.862.86
375.473.863.86
389.480.480.48
451.613.153.15
305.421.991.99
485.584.144.14
393.914.814.81
427.554.354.35
284.361.341.34
399.494.004.00
414.512.862.86
425.531.441.44
427.452.702.70
406.492.472.47
391.523.933.93
303.410.180.18
324.421.761.76
457.573.783.78
409.531.591.59
423.562.732.73
433.530.510.51
412.544.074.07
505.625.525.52
383.450.700.70
361.442.942.94
350.422.072.07
413.524.044.04
352.482.702.70
399.922.412.41
510.644.124.12
404.512.172.17
402.502.792.79
350.423.143.14
391.523.933.93
397.481.561.56
413.533.473.47
461.915.825.82
483.614.854.85
438.571.351.35
349.432.872.87
527.632.182.18
391.472.502.50
414.513.433.43
315.421.841.84
483.623.823.82
338.452.152.15
413.524.044.04
418.503.163.16
526.643.363.36
423.562.452.45
441.584.774.77
410.562.932.93
496.664.774.77
389.504.164.16
417.513.923.92
311.391.381.38
391.472.152.15
423.944.814.81
539.683.283.28
399.494.034.03
399.494.034.03
389.480.480.48
524.674.684.68
403.524.474.47
410.512.392.39
427.554.354.35
395.501.961.96
390.492.242.24
417.513.163.16
389.504.164.16
393.442.722.72
399.494.004.00
427.475.175.17
455.564.074.07
403.483.883.88
511.632.952.95
426.564.954.95
412.544.074.07
406.492.472.47
391.472.152.15
420.512.002.00
298.392.022.02
439.561.431.43
387.482.902.90
483.623.253.25
389.503.643.64
359.474.154.15
434.542.212.21
427.554.354.35
433.530.970.97
389.480.480.48
414.513.403.40
404.472.532.53
398.460.950.95
433.530.970.97
483.624.284.28
423.562.072.07
360.463.553.55
416.523.513.51
365.524.534.53
437.582.412.41
496.664.204.20
366.293.933.93
433.530.640.64
414.512.862.86
406.491.991.99
407.472.752.75
419.500.250.25
339.441.221.22
456.594.394.39
393.583.573.57
439.562.192.19
466.603.403.40
354.451.941.94
511.633.523.52
406.491.991.99
536.684.634.63
455.572.472.47
384.481.061.06
468.604.044.04
358.411.741.74
419.532.872.87
421.502.162.16
330.472.492.49
413.524.044.04
525.653.913.91
290.411.171.17
325.411.161.16
366.512.702.70
423.944.814.81
434.520.370.37
530.650.450.45
409.532.432.43
383.491.671.67
449.504.594.59
463.581.831.83
381.481.651.65
524.674.114.11
427.475.175.17
326.402.192.19
380.533.093.09
397.480.960.96
393.532.602.60
408.551.821.82
410.524.704.70
405.502.542.54
311.381.231.23
410.563.533.53
383.450.700.70
469.594.414.41
409.531.671.67
482.633.853.85
325.412.232.23
389.504.064.06
413.524.044.04
401.514.354.35
298.392.022.02
394.521.251.25
397.521.781.78
443.554.054.05
375.473.013.01
401.510.550.55
450.581.591.59
405.502.542.54
402.493.253.25
502.640.540.54
339.441.221.22
363.462.892.89
410.521.821.82
365.431.471.47
451.575.945.94
310.401.841.84
414.512.862.86
525.654.084.08
362.472.042.04
400.484.294.29
391.472.502.50
383.450.700.70
503.655.825.82
391.472.502.50
384.484.024.02
375.472.312.31
339.441.221.22
353.420.930.93
409.532.432.43
354.451.911.91
399.494.034.03
440.583.533.53
378.453.693.69
477.915.705.70
409.531.631.63
291.391.601.60
413.533.473.47
370.451.611.61
463.581.881.88
413.533.473.47
519.655.665.66
403.501.211.21
379.502.262.26
434.542.212.21
424.551.011.01
395.454.434.43
536.684.634.63
387.482.902.90
437.563.563.56
413.533.473.47
383.491.671.67
485.633.553.55
413.533.473.47
395.501.251.25
392.461.541.54
399.922.412.41
414.513.433.43
468.603.993.99