Basic Information
ID: ALA3880799
Type: Binding
Description: Inhibition of recombinant human untagged NAEalpha/N-terminal His-tagged NAEbeta expressed in Bac-to-Bac expression system using FLAG-tagged NEDD8 as substrate after 90 mins in presence of GST-tagged Ubc12 by HTRF assay
Organism: Homo sapiens
Activity Charts
Bioactivity
Activity Types for Assay ALA3880799
IC50
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 462.49 | -0.23 | -0.23 |
| 404.41 | -2.28 | -2.28 |
| 442.48 | -0.66 | -0.66 |
| 473.47 | -0.48 | -0.48 |
| 499.43 | 0.08 | 0.08 |
| 462.49 | -0.23 | -0.23 |
| 450.48 | -0.68 | -0.68 |
| 465.49 | -1.27 | -1.27 |
| 475.41 | 0.35 | 0.35 |
| 520.45 | 0.18 | 0.18 |
| 371.38 | -1.46 | -1.46 |
| 465.49 | -1.14 | -1.14 |
| 478.49 | -1.26 | -1.26 |
| 461.50 | 0.37 | 0.37 |
| 500.44 | -1.13 | -1.13 |
| 507.53 | -1.09 | -1.09 |
| 470.90 | -0.07 | -0.07 |
| 446.53 | 1.65 | 1.65 |
| 465.49 | -1.62 | -1.62 |
| 465.88 | -0.28 | -0.28 |
| 437.45 | 0.43 | 0.43 |
| 452.45 | -1.62 | -1.62 |
| 345.34 | -2.03 | -2.03 |
| 465.49 | -1.62 | -1.62 |
| 314.32 | -0.70 | -0.70 |
| 435.47 | -1.15 | -1.15 |
| 454.44 | -0.58 | -0.58 |
| 484.88 | -0.43 | -0.43 |
| 459.49 | -2.59 | -2.59 |
| 467.41 | -0.66 | -0.66 |
| 476.52 | 0.15 | 0.15 |
| 477.50 | -1.69 | -1.69 |
| 443.49 | -1.92 | -1.92 |
| 413.46 | 0.76 | 0.76 |
| 435.46 | -0.55 | -0.55 |
| 443.49 | -1.83 | -1.83 |
| 439.43 | -0.60 | -0.60 |
| 385.45 | -0.47 | -0.47 |
| 465.45 | -2.01 | -2.01 |
| 456.87 | 0.06 | 0.06 |
| 479.48 | -1.42 | -1.42 |
| 430.45 | -1.36 | -1.36 |
| 387.42 | -1.14 | -1.14 |
| 371.42 | 0.04 | 0.04 |
| 459.53 | 0.00 | 0.00 |
| 442.50 | -0.34 | -0.34 |
| 510.33 | -0.17 | -0.17 |
| 468.42 | -0.94 | -0.94 |
| 476.52 | 0.42 | 0.42 |
| 529.33 | -0.32 | -0.32 |
| 433.45 | -0.16 | -0.16 |
| 480.46 | -1.07 | -1.07 |
| 461.50 | -0.66 | -0.66 |
| 451.47 | -2.05 | -2.05 |
| 476.52 | 0.16 | 0.16 |
| 461.50 | -0.38 | -0.38 |
| 481.49 | -1.91 | -1.91 |
| 461.50 | 0.37 | 0.37 |
| 444.52 | 1.46 | 1.46 |
| 491.56 | 0.07 | 0.07 |
| 397.37 | -1.07 | -1.07 |
| 344.35 | -0.69 | -0.69 |
| 407.41 | -0.67 | -0.67 |
| 443.53 | 2.06 | 2.06 |
| 490.45 | -1.54 | -1.54 |
| 480.46 | -0.99 | -0.99 |
| 403.42 | -2.70 | -2.70 |
| 450.43 | -1.08 | -1.08 |
| 466.48 | -0.71 | -0.71 |
| 510.58 | 1.33 | 1.33 |
| 449.42 | -0.80 | -0.80 |
| 462.49 | -0.82 | -0.82 |
| 446.49 | 0.79 | 0.79 |
| 496.93 | 0.42 | 0.42 |
| 359.36 | -1.77 | -1.77 |
| 488.57 | 0.96 | 0.96 |
| 461.50 | -0.66 | -0.66 |
| 486.51 | 0.43 | 0.43 |
| 466.48 | -0.71 | -0.71 |
| 465.45 | -0.69 | -0.69 |
| 476.52 | -0.81 | -0.81 |
| 462.49 | -0.24 | -0.24 |
| 494.49 | -1.40 | -1.40 |
| 548.63 | -1.10 | -1.10 |
| 449.42 | -0.80 | -0.80 |
| 460.52 | 0.22 | 0.22 |
| 499.43 | 0.08 | 0.08 |
| 415.43 | 0.09 | 0.09 |
| 460.52 | 0.43 | 0.43 |
| 467.41 | -0.66 | -0.66 |
| 510.33 | -0.17 | -0.17 |
| 461.46 | -0.93 | -0.93 |
| 476.52 | -0.21 | -0.21 |
| 464.46 | -1.40 | -1.40 |
| 426.41 | -1.06 | -1.06 |
| 466.48 | -1.19 | -1.19 |
| 510.33 | -0.17 | -0.17 |
| 464.48 | 0.74 | 0.74 |
| 466.48 | -1.19 | -1.19 |
| 465.88 | -0.28 | -0.28 |
| 420.45 | 0.31 | 0.31 |
| 433.49 | 0.11 | 0.11 |
| 445.50 | 1.40 | 1.40 |
| 429.46 | -0.27 | -0.27 |
| 431.43 | -0.93 | -0.93 |
| 418.48 | 1.52 | 1.52 |
| 436.45 | -0.72 | -0.72 |
| 441.47 | -3.78 | -3.78 |
| 476.52 | 0.42 | 0.42 |
| 441.50 | -1.09 | -1.09 |
| 395.40 | -1.57 | -1.57 |
| 525.59 | 0.48 | 0.48 |
| 371.42 | -0.72 | -0.72 |
| 433.45 | 0.55 | 0.55 |
| 485.53 | 0.00 | 0.00 |
| 449.42 | -0.80 | -0.80 |
| 486.49 | -1.53 | -1.53 |
| 465.88 | -0.28 | -0.28 |
| 461.46 | -0.93 | -0.93 |
| 446.49 | 0.79 | 0.79 |
| 442.50 | 1.07 | 1.07 |
| 477.50 | -0.65 | -0.65 |
| 468.92 | 0.39 | 0.39 |