Basic Information
ID: ALA3881122
Type: Binding
Description: Inhibition of mouse recombinant ICE assessed as ratio of irreversible rate constant K3 to dissociation constant of the reversible binding step Ki pre-incubated for 60 mins with Acetyl-Tyr-Val-Ala-Asp-amino-4-methylcoumarin substrate followed by enzyme addition by fluorescence based assay
Organism: Mus musculus
Activity Charts
Bioactivity
Activity Types for Assay ALA3881122
Ratio
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 569.61 | 3.68 | 3.68 |
| 595.55 | 2.49 | 2.49 |
| 568.54 | 1.30 | 1.30 |
| 609.45 | 2.95 | 2.95 |
| 639.64 | 4.44 | 4.44 |
| 653.67 | 4.52 | 4.52 |
| 569.51 | 1.65 | 1.65 |
| 555.53 | 2.80 | 2.80 |
| 541.45 | 1.93 | 1.93 |
| 605.54 | 2.76 | 2.76 |
| 575.90 | 2.58 | 2.58 |
| 559.44 | 2.07 | 2.07 |
| 559.44 | 2.07 | 2.07 |
| 555.48 | 1.61 | 1.61 |
| 616.45 | 3.61 | 3.61 |
| 591.51 | 3.08 | 3.08 |
| 573.52 | 2.94 | 2.94 |
| 581.56 | 2.70 | 2.70 |
| 589.53 | 2.34 | 2.34 |
| 631.58 | 3.20 | 3.20 |
| 599.58 | 2.38 | 2.38 |
| 577.43 | 2.21 | 2.21 |
| 597.56 | 3.23 | 3.23 |
| 667.35 | 2.53 | 2.53 |
| 620.35 | 2.69 | 2.69 |
| 643.63 | 3.39 | 3.39 |
| 617.55 | 3.60 | 3.60 |
| 631.58 | 3.52 | 3.52 |
| 571.48 | 1.94 | 1.94 |
| 527.43 | 0.97 | 0.97 |
| 531.39 | 1.43 | 1.43 |
| 603.53 | 2.88 | 2.88 |
| 621.63 | 2.90 | 2.90 |
| 594.45 | 3.12 | 3.12 |
| 625.62 | 3.89 | 3.89 |
| 677.74 | 4.20 | 4.20 |
| 650.56 | 4.42 | 4.42 |
| 599.96 | 2.26 | 2.26 |
| 572.79 | 2.48 | 2.48 |
| 641.62 | 3.27 | 3.27 |
| 614.44 | 3.49 | 3.49 |
| 453.47 | 0.94 | 0.94 |
| 543.43 | 0.72 | 0.72 |
| 542.44 | 1.32 | 1.32 |
| 542.44 | 1.32 | 1.32 |
| 556.33 | 1.96 | 1.96 |
| 571.52 | 1.74 | 1.74 |
| 535.55 | 2.23 | 2.23 |
| 556.33 | 1.96 | 1.96 |
| 619.61 | 2.48 | 2.48 |
| 593.57 | 1.32 | 1.32 |
| 663.68 | 4.30 | 4.30 |
| 535.53 | 2.54 | 2.54 |
| 571.57 | 1.41 | 1.41 |
| 648.40 | 3.35 | 3.35 |
| 544.39 | 1.63 | 1.63 |
| 577.63 | 3.32 | 3.32 |
| 629.61 | 2.44 | 2.44 |
| 623.64 | 2.05 | 2.05 |
| 552.37 | 1.50 | 1.50 |
| 718.62 | 2.46 | 2.46 |
| 445.45 | 1.42 | 1.42 |
| 592.43 | 2.70 | 2.70 |
| 515.54 | 2.17 | 2.17 |
| 567.49 | 2.17 | 2.17 |
| 614.40 | 1.88 | 1.88 |
| 551.55 | 1.79 | 1.79 |
| 581.48 | 1.81 | 1.81 |
| 702.62 | 3.22 | 3.22 |
| 602.43 | 2.65 | 2.65 |
| 577.49 | 2.12 | 2.12 |
| 596.46 | 2.27 | 2.27 |
| 619.63 | 3.58 | 3.58 |
| 664.24 | 2.43 | 2.43 |
| 583.53 | 2.28 | 2.28 |
| 583.51 | 1.74 | 1.74 |
| 691.41 | 2.21 | 2.21 |