Basic Information
ID: ALA3881394
Type: Binding
Description: Inhibition of human NHE3-mediated sodium-dependant hydrogen ion antiport in Opossum kidney cells preincubated in NH4Cl-HEPES buffer containing BCECF-AM dye followed by washout with ammonium free HEPES and subsequent addition of compound in presence of NHE1 antagonist EIPA by fluorescence assay
Organism: Homo sapiens
Cell type: kidney
Activity Charts
Bioactivity
Activity Types for Assay ALA3881394
IC50
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 1145.07 | ||
| 1145.07 | ||
| 1829.71 | ||
| 1205.12 | ||
| 1888.82 | ||
| 1907.78 | ||
| 1757.65 | ||
| 1921.80 | ||
| 1761.63 | ||
| 1868.87 | ||
| 1263.54 | ||
| 1815.77 | ||
| 1787.72 | ||
| 1815.77 | ||
| 513.05 | 1.97 | 1.97 |
| 1309.65 | ||
| 1858.75 | ||
| 1848.72 | ||
| 1778.69 | ||
| 1088.19 | ||
| 1314.39 | ||
| 1397.76 | ||
| 2318.15 | ||
| 1800.67 | ||
| 1582.57 | ||
| 1777.63 | ||
| 1252.34 | ||
| 503.67 | 2.49 | 2.49 |
| 1351.65 | ||
| 1728.65 | ||
| 1466.49 | ||
| 1289.20 | ||
| 1225.54 | ||
| 1437.45 | ||
| 1256.29 | ||
| 1137.43 | ||
| 1485.59 | ||
| 1136.23 | ||
| 1582.57 | ||
| 1801.65 | ||
| 1225.30 | ||
| 1437.45 | ||
| 1283.34 | ||
| 2518.43 | ||
| 1854.76 | ||
| 1776.64 | ||
| 1644.49 | ||
| 1309.39 | ||
| 1773.69 | ||
| 1810.67 | ||
| 1104.19 | ||
| 1140.15 | ||
| 1504.63 | ||
| 1901.26 | ||
| 513.05 | 1.97 | 1.97 |
| 1743.62 | ||
| 508.00 | 1.53 | 1.53 |
| 1183.45 | ||
| 1814.69 | ||
| 1727.62 | ||
| 1832.75 | ||
| 1163.04 | ||
| 1818.73 | ||
| 1826.75 | ||
| 1573.70 | ||
| 1645.47 | ||
| 1718.81 | ||
| 1788.73 | ||
| 1857.86 | ||
| 508.00 | 1.53 | 1.53 |
| 585.63 | 1.25 | 1.25 |
| 444.92 | 2.23 | 2.23 |
| 1218.16 | ||
| 3035.86 | ||
| 552.06 | 1.54 | 1.54 |
| 1147.04 | ||
| 1831.68 | ||
| 2622.49 | ||
| 1285.25 | ||
| 1785.70 | ||
| 1225.11 | ||
| 1851.74 | ||
| 1837.62 | ||
| 2514.44 | ||
| 1742.67 | ||
| 1718.81 | ||
| 1994.90 | ||
| 1261.14 | ||
| 1416.52 | ||
| 1573.70 | ||
| 1686.57 | ||
| 1103.32 | ||
| 485.36 | 0.95 | 0.95 |
| 1771.67 | ||
| 2047.40 | ||
| 1416.52 | ||
| 1137.43 | ||
| 1859.69 | ||
| 1373.42 | ||
| 1206.54 | ||
| 1905.85 | ||
| 1067.34 | ||
| 1856.78 | ||
| 2572.53 | ||
| 1089.50 | ||
| 1172.21 | ||
| 2033.42 | ||
| 1118.43 | ||
| 488.98 | 2.64 | 2.64 |
| 1817.70 | ||
| 1827.78 | ||
| 1191.52 | ||
| 1318.23 | ||
| 1728.65 | ||
| 557.10 | 1.99 | 1.99 |
| 1514.63 | ||
| 2494.36 | ||
| 546.52 | 2.86 | 2.86 |
| 2798.70 | ||
| 1903.79 | ||
| 1847.72 | ||
| 1235.58 | ||
| 1427.47 | ||
| 1119.42 | ||
| 1339.46 | ||
| 1795.65 | ||
| 2093.06 | ||
| 372.49 | 2.86 | 2.86 |
| 1844.72 | ||
| 1121.39 | ||
| 1225.54 | ||
| 1315.28 | ||
| 1207.09 | ||
| 1863.77 | ||
| 1731.61 | ||
| 1285.32 | ||
| 1273.40 | ||
| 1147.47 | ||
| 1179.04 | ||
| 1787.72 | ||
| 1233.18 | ||
| 1311.40 | ||
| 1371.45 | ||
| 444.92 | 2.23 | 2.23 |
| 2180.18 | ||
| 1209.49 | ||
| 1905.85 | ||
| 1900.83 | ||
| 1808.69 | ||
| 1282.36 | ||
| 1161.06 | ||
| 1861.71 | ||
| 1887.79 | ||
| 1815.77 | ||
| 1816.67 | ||
| 1729.63 | ||
| 429.37 | 3.50 | 3.50 |
| 572.56 | 3.79 | 3.79 |
| 2446.32 | ||
| 1105.39 | ||
| 1700.59 | ||
| 1349.25 |