Basic Information
ID: ALA3882089
Type: Binding
Description: Inhibition of N-terminal GST-His6-thrombin cleavage site-fused human PDGFRbeta (Arg561 to Leu1106 residues) assessed as decrease in biotinylated FLT3 phosphorylation at Tyr589 preincubated for 5 mins followed by substrate addition measured after 30 mins by DELFIA method
Organism: Homo sapiens
Activity Charts
Bioactivity
Activity Types for Assay ALA3882089
IC50
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 518.04 | 5.07 | 5.07 |
| 573.12 | 4.39 | 4.39 |
| 587.15 | 4.78 | 4.78 |
| 559.10 | 4.00 | 4.00 |
| 456.52 | 3.84 | 3.84 |
| 579.96 | 5.99 | 5.99 |
| 400.41 | 2.28 | 2.28 |
| 428.46 | 3.06 | 3.06 |
| 517.02 | 2.83 | 2.83 |
| 579.96 | 6.58 | 6.58 |
| 531.04 | 3.22 | 3.22 |
| 608.02 | 6.65 | 6.65 |
| 442.49 | 3.45 | 3.45 |
| 547.09 | 4.27 | 4.27 |
| 608.02 | 6.77 | 6.77 |
| 386.38 | 1.89 | 1.89 |
| 579.96 | 5.87 | 5.87 |
| 504.02 | 4.68 | 4.68 |