Basic Information
ID: ALA3882744
Type: Binding
Description: Inhibition of CYP17 in human testicular microsomes using 17alpha-hydroxypregnenolone as substrate assessed as decrease in DHEA levels after 90 mins by ELISA
Format: BAO_0000019
Organism: Homo sapiens
Tissue: Testis
Subcellular Fraction: Microsomes
Target: Cytochrome P450 17A1(ALA3522)
Document: ALA3882724
Inhibition of CYP17 in human testicular microsomes using 17alpha-hydroxypregnenolone as substrate assessed as decrease in DHEA levels after 90 mins by ELISA: 38
Activity Charts
Bioactivity
Activity Types for Assay ALA3882744
IC50
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 349.52 | 5.40 | 5.40 |
| 448.64 | 5.55 | 5.55 |
| 374.53 | 5.03 | 5.03 |
| 374.53 | 5.96 | 5.96 |
| 406.55 | 5.41 | 5.41 |
| 363.59 | 7.21 | 7.21 |
| 353.51 | 4.10 | 4.10 |
| 387.49 | 6.81 | 6.81 |
| 371.95 | 5.74 | 5.74 |
| 349.52 | 5.70 | 5.70 |
| 437.60 | 5.86 | 5.86 |
| 446.64 | 6.85 | 6.85 |
| 390.57 | 5.54 | 5.54 |
| 347.50 | 5.61 | 5.61 |
| 363.55 | 5.79 | 5.79 |
| 446.64 | 5.94 | 5.94 |
| 418.63 | 6.32 | 6.32 |
| 432.61 | 5.43 | 5.43 |
| 359.51 | 5.92 | 5.92 |
| 357.50 | 5.55 | 5.55 |
| 363.55 | 5.48 | 5.48 |
| 419.61 | 5.58 | 5.58 |
| 374.53 | 5.89 | 5.89 |
| 338.54 | 6.16 | 6.16 |
| 347.50 | 5.32 | 5.32 |
| 414.55 | 5.05 | 5.05 |
| 383.54 | 4.70 | 4.70 |
| 363.55 | 5.79 | 5.79 |
| 338.50 | 4.95 | 4.95 |
| 364.53 | 4.98 | 4.98 |
| 379.59 | 6.91 | 6.91 |
| 355.48 | 5.47 | 5.47 |
| 390.53 | 4.69 | 4.69 |
| 392.52 | 5.07 | 5.07 |
| 367.51 | 5.54 | 5.54 |
| 359.47 | 5.19 | 5.19 |
| 467.61 | 6.97 | 6.97 |
| 424.54 | 5.87 | 5.87 |
| 363.55 | 5.94 | 5.94 |
| 403.57 | 6.28 | 6.28 |
| 362.52 | 4.76 | 4.76 |
| 409.61 | 5.62 | 5.62 |
| 377.62 | 7.46 | 7.46 |
| 409.61 | 6.53 | 6.53 |
| 400.01 | 6.52 | 6.52 |
| 367.51 | 5.54 | 5.54 |
| 365.56 | 5.72 | 5.72 |
| 390.57 | 5.41 | 5.41 |
| 385.55 | 6.16 | 6.16 |
| 397.51 | 6.26 | 6.26 |
| 378.56 | 5.15 | 5.15 |
| 365.56 | 6.05 | 6.05 |
| 325.46 | 3.95 | 3.95 |
| 412.52 | 5.70 | 5.70 |
| 414.54 | 5.78 | 5.78 |
| 334.46 | 4.79 | 4.79 |
| 397.56 | 5.05 | 5.05 |
| 364.58 | 5.71 | 5.71 |
| 426.63 | 4.96 | 4.96 |
| 479.66 | 7.80 | 7.80 |
| 415.57 | 6.66 | 6.66 |
| 419.61 | 6.53 | 6.53 |
| 463.62 | 4.86 | 4.86 |
| 324.47 | 4.56 | 4.56 |
| 381.54 | 5.85 | 5.85 |
| 349.52 | 5.69 | 5.69 |
| 388.56 | 5.27 | 5.27 |
| 363.55 | 6.44 | 6.44 |
| 359.51 | 5.77 | 5.77 |
| 355.53 | 4.79 | 4.79 |
| 363.48 | 5.67 | 5.67 |
| 405.58 | 6.28 | 6.28 |
| 383.55 | 5.86 | 5.86 |
| 346.47 | 4.92 | 4.92 |
| 380.51 | 5.20 | 5.20 |
| 390.62 | 6.14 | 6.14 |
| 379.59 | 6.44 | 6.44 |
| 369.50 | 6.67 | 6.67 |
| 377.53 | 4.72 | 4.72 |
| 363.51 | 4.16 | 4.16 |
| 376.54 | 5.07 | 5.07 |
| 458.57 | 6.56 | 6.56 |
| 327.47 | 3.74 | 3.74 |
| 396.53 | 4.44 | 4.44 |
| 440.58 | 6.48 | 6.48 |
| 363.55 | 5.71 | 5.71 |
| 380.51 | 5.82 | 5.82 |
| 377.50 | 5.60 | 5.60 |
| 365.56 | 6.13 | 6.13 |
| 381.56 | 4.84 | 4.84 |
| 379.52 | 5.99 | 5.99 |
| 420.64 | 6.26 | 6.26 |
| 363.55 | 5.79 | 5.79 |
| 378.60 | 6.01 | 6.01 |
| 367.51 | 5.54 | 5.54 |
| 374.53 | 5.36 | 5.36 |
| 375.56 | 5.95 | 5.95 |
| 361.53 | 6.00 | 6.00 |
| 451.61 | 7.18 | 7.18 |
| 405.58 | 6.19 | 6.19 |