Basic Information
ID: ALA3882745
Type: Binding
Description: Inhibition of CYP17 in human testicular microsomes using 17alpha-hydroxypregnenolone as substrate assessed as decrease in DHEA levels at 10 nM after 90 mins by ELISA relative to control
Format: BAO_0000019
Organism: Homo sapiens
Tissue: Testis
Subcellular Fraction: Microsomes
Target: Cytochrome P450 17A1(ALA3522)
Document: ALA3882724
Inhibition of CYP17 in human testicular microsomes using 17alpha-hydroxypregnenolone as substrate assessed as decrease in DHEA levels at 10 nM after 90 mins by ELISA relative to control: 38
Activity Charts
Bioactivity
Activity Types for Assay ALA3882745
Inhibition
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 347.50 | 5.61 | 5.61 |
| 448.64 | 5.55 | 5.55 |
| 385.52 | 4.54 | 4.54 |
| 406.57 | 5.36 | 5.36 |
| 393.62 | 7.30 | 7.30 |
| 379.59 | 6.44 | 6.44 |
| 441.59 | 7.14 | 7.14 |
| 379.59 | 5.97 | 5.97 |
| 353.51 | 4.10 | 4.10 |
| 381.56 | 4.84 | 4.84 |
| 360.49 | 6.01 | 6.01 |
| 353.51 | 4.10 | 4.10 |
| 349.52 | 5.70 | 5.70 |
| 361.53 | 5.63 | 5.63 |
| 437.60 | 5.86 | 5.86 |
| 446.64 | 6.85 | 6.85 |
| 347.50 | 5.61 | 5.61 |
| 417.59 | 6.53 | 6.53 |
| 446.64 | 5.94 | 5.94 |
| 373.54 | 6.00 | 6.00 |
| 363.55 | 5.79 | 5.79 |
| 401.50 | 4.89 | 4.89 |
| 422.61 | 5.87 | 5.87 |
| 392.54 | 5.07 | 5.07 |
| 338.54 | 6.16 | 6.16 |
| 378.56 | 5.23 | 5.23 |
| 347.50 | 5.32 | 5.32 |
| 414.55 | 5.05 | 5.05 |
| 383.54 | 4.70 | 4.70 |
| 363.55 | 5.79 | 5.79 |
| 496.60 | 5.66 | 5.66 |
| 382.52 | 4.98 | 4.98 |
| 338.50 | 4.95 | 4.95 |
| 363.50 | 4.53 | 4.53 |
| 367.51 | 5.54 | 5.54 |
| 377.57 | 6.18 | 6.18 |
| 359.47 | 5.19 | 5.19 |
| 362.52 | 5.39 | 5.39 |
| 424.54 | 5.87 | 5.87 |
| 362.52 | 4.76 | 4.76 |
| 348.49 | 5.00 | 5.00 |
| 465.64 | 7.49 | 7.49 |
| 367.51 | 5.54 | 5.54 |
| 377.62 | 7.46 | 7.46 |
| 377.50 | 5.77 | 5.77 |
| 360.50 | 4.68 | 4.68 |
| 362.52 | 4.76 | 4.76 |
| 397.51 | 6.26 | 6.26 |
| 365.56 | 6.05 | 6.05 |
| 378.60 | 6.12 | 6.12 |
| 325.46 | 3.95 | 3.95 |
| 389.51 | 6.89 | 6.89 |
| 390.57 | 6.50 | 6.50 |
| 442.63 | 4.12 | 4.12 |
| 376.54 | 5.07 | 5.07 |
| 334.46 | 4.79 | 4.79 |
| 379.59 | 6.11 | 6.11 |
| 340.51 | 3.97 | 3.97 |
| 379.55 | 4.80 | 4.80 |
| 363.50 | 4.53 | 4.53 |
| 357.50 | 5.69 | 5.69 |
| 352.52 | 5.31 | 5.31 |
| 349.48 | 3.94 | 3.94 |
| 394.56 | 5.09 | 5.09 |
| 376.55 | 6.80 | 6.80 |
| 479.66 | 7.80 | 7.80 |
| 415.57 | 6.66 | 6.66 |
| 405.56 | 6.38 | 6.38 |
| 434.62 | 5.89 | 5.89 |
| 430.64 | 6.32 | 6.32 |
| 472.67 | 6.21 | 6.21 |
| 363.55 | 6.44 | 6.44 |
| 363.55 | 5.93 | 5.93 |
| 384.01 | 7.55 | 7.55 |
| 381.54 | 5.93 | 5.93 |
| 357.49 | 6.36 | 6.36 |
| 352.52 | 5.00 | 5.00 |
| 341.50 | 4.13 | 4.13 |
| 406.61 | 5.96 | 5.96 |
| 351.54 | 4.84 | 4.84 |
| 369.50 | 6.67 | 6.67 |
| 376.54 | 5.07 | 5.07 |
| 458.57 | 6.56 | 6.56 |
| 363.55 | 5.79 | 5.79 |
| 411.54 | 6.79 | 6.79 |
| 377.50 | 5.60 | 5.60 |
| 365.56 | 6.13 | 6.13 |
| 371.52 | 5.77 | 5.77 |
| 382.55 | 4.23 | 4.23 |
| 365.52 | 5.27 | 5.27 |
| 376.54 | 6.11 | 6.11 |
| 383.55 | 6.01 | 6.01 |
| 421.58 | 6.92 | 6.92 |
| 389.51 | 6.06 | 6.06 |
| 392.59 | 5.62 | 5.62 |
| 422.61 | 5.63 | 5.63 |
| 376.54 | 5.07 | 5.07 |
| 375.56 | 5.95 | 5.95 |
| 369.55 | 4.81 | 4.81 |
| 405.58 | 6.19 | 6.19 |