Basic Information
ID: ALA3882750
Type: Binding
Description: Inhibition of Sprague-Dawley rat adrenal mitochondrial CYP11B assessed as decrease in conversion of 11-deoxycortisol to cortisol at 100 nM incubated for 60 mins by ELISA relative to control
Organism: Rattus norvegicus
Strain: Sprague-Dawley
Activity Charts
Bioactivity
Activity Types for Assay ALA3882750
Inhibition
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 347.50 | 5.61 | 5.61 |
| 349.52 | 5.40 | 5.40 |
| 272.43 | 4.91 | 4.91 |
| 448.64 | 5.55 | 5.55 |
| 385.52 | 4.54 | 4.54 |
| 374.53 | 5.03 | 5.03 |
| 351.54 | 4.57 | 4.57 |
| 394.56 | 4.48 | 4.48 |
| 408.63 | 6.34 | 6.34 |
| 343.47 | 5.30 | 5.30 |
| 371.52 | 5.92 | 5.92 |
| 388.56 | 5.15 | 5.15 |
| 406.57 | 5.36 | 5.36 |
| 337.47 | 3.93 | 3.93 |
| 395.55 | 5.02 | 5.02 |
| 374.53 | 5.96 | 5.96 |
| 350.51 | 5.26 | 5.26 |
| 393.62 | 7.30 | 7.30 |
| 383.96 | 6.05 | 6.05 |
| 379.59 | 6.44 | 6.44 |
| 406.55 | 5.41 | 5.41 |
| 403.57 | 5.11 | 5.11 |
| 363.59 | 7.21 | 7.21 |
| 441.59 | 7.14 | 7.14 |
| 392.52 | 5.07 | 5.07 |
| 389.54 | 5.89 | 5.89 |
| 381.54 | 5.93 | 5.93 |
| 393.62 | 6.70 | 6.70 |
| 379.59 | 5.97 | 5.97 |
| 442.63 | 4.77 | 4.77 |
| 350.51 | 5.26 | 5.26 |
| 353.51 | 4.10 | 4.10 |
| 397.51 | 6.54 | 6.54 |
| 479.66 | 7.80 | 7.80 |
| 345.49 | 5.53 | 5.53 |
| 381.56 | 4.84 | 4.84 |
| 378.56 | 5.39 | 5.39 |
| 387.49 | 6.81 | 6.81 |
| 375.52 | 4.42 | 4.42 |
| 360.49 | 6.01 | 6.01 |
| 371.95 | 5.74 | 5.74 |
| 353.51 | 4.10 | 4.10 |
| 351.49 | 4.32 | 4.32 |
| 452.66 | 5.49 | 5.49 |
| 349.52 | 5.70 | 5.70 |
| 381.49 | 5.00 | 5.00 |
| 378.49 | 4.82 | 4.82 |
| 361.53 | 5.63 | 5.63 |
| 348.49 | 4.67 | 4.67 |
| 437.60 | 5.86 | 5.86 |
| 446.64 | 6.85 | 6.85 |
| 379.54 | 5.58 | 5.58 |
| 390.57 | 5.73 | 5.73 |
| 376.50 | 4.19 | 4.19 |
| 390.57 | 5.54 | 5.54 |
| 392.52 | 5.17 | 5.17 |
| 347.50 | 5.61 | 5.61 |
| 363.55 | 5.79 | 5.79 |
| 392.59 | 5.59 | 5.59 |
| 417.59 | 6.53 | 6.53 |
| 408.56 | 5.68 | 5.68 |
| 446.64 | 5.94 | 5.94 |
| 393.55 | 6.38 | 6.38 |
| 408.59 | 4.98 | 4.98 |
| 392.59 | 5.41 | 5.41 |
| 365.52 | 5.27 | 5.27 |
| 345.49 | 5.38 | 5.38 |
| 373.54 | 6.00 | 6.00 |
| 408.59 | 5.84 | 5.84 |
| 418.63 | 6.32 | 6.32 |
| 380.53 | 4.17 | 4.17 |
| 326.48 | 4.35 | 4.35 |
| 390.57 | 5.54 | 5.54 |
| 363.55 | 5.79 | 5.79 |
| 432.61 | 5.43 | 5.43 |
| 420.64 | 6.37 | 6.37 |
| 420.64 | 6.27 | 6.27 |
| 359.51 | 5.92 | 5.92 |
| 353.51 | 4.11 | 4.11 |
| 357.50 | 5.55 | 5.55 |
| 401.50 | 4.89 | 4.89 |
| 422.61 | 5.87 | 5.87 |
| 363.55 | 5.48 | 5.48 |
| 419.61 | 5.58 | 5.58 |
| 382.55 | 5.31 | 5.31 |
| 374.53 | 5.89 | 5.89 |
| 392.54 | 5.07 | 5.07 |
| 338.54 | 6.16 | 6.16 |
| 363.55 | 6.05 | 6.05 |
| 378.56 | 5.23 | 5.23 |
| 347.50 | 5.32 | 5.32 |
| 362.52 | 4.86 | 4.86 |
| 414.55 | 5.05 | 5.05 |
| 380.51 | 5.20 | 5.20 |
| 406.57 | 5.11 | 5.11 |
| 350.55 | 5.56 | 5.56 |
| 377.57 | 6.36 | 6.36 |
| 383.54 | 4.70 | 4.70 |
| 377.50 | 5.91 | 5.91 |
| 375.51 | 5.54 | 5.54 |
| 459.66 | 6.29 | 6.29 |
| 388.56 | 6.26 | 6.26 |
| 363.55 | 5.79 | 5.79 |
| 386.54 | 4.88 | 4.88 |
| 378.52 | 4.68 | 4.68 |
| 496.60 | 5.66 | 5.66 |
| 382.52 | 4.98 | 4.98 |
| 338.50 | 4.95 | 4.95 |
| 340.51 | 4.74 | 4.74 |
| 363.59 | 7.21 | 7.21 |
| 352.48 | 3.42 | 3.42 |
| 363.55 | 5.48 | 5.48 |
| 405.59 | 5.19 | 5.19 |
| 378.56 | 5.15 | 5.15 |
| 364.53 | 4.98 | 4.98 |
| 390.57 | 5.33 | 5.33 |
| 363.50 | 4.53 | 4.53 |
| 379.59 | 6.91 | 6.91 |
| 362.56 | 5.58 | 5.58 |
| 355.48 | 5.47 | 5.47 |
| 390.53 | 4.69 | 4.69 |
| 392.52 | 5.07 | 5.07 |
| 361.49 | 5.27 | 5.27 |
| 359.51 | 5.46 | 5.46 |
| 383.51 | 4.75 | 4.75 |
| 420.60 | 5.55 | 5.55 |
| 367.51 | 5.54 | 5.54 |
| 351.53 | 5.48 | 5.48 |
| 377.57 | 6.03 | 6.03 |
| 390.57 | 5.33 | 5.33 |
| 406.61 | 5.97 | 5.97 |
| 415.57 | 6.66 | 6.66 |
| 377.57 | 6.18 | 6.18 |
| 359.47 | 5.19 | 5.19 |
| 431.65 | 6.66 | 6.66 |
| 362.52 | 5.39 | 5.39 |
| 467.61 | 6.97 | 6.97 |
| 415.58 | 5.52 | 5.52 |
| 406.61 | 5.97 | 5.97 |
| 424.54 | 5.87 | 5.87 |
| 362.52 | 4.76 | 4.76 |
| 379.59 | 6.26 | 6.26 |
| 410.61 | 5.06 | 5.06 |
| 507.72 | 8.48 | 8.48 |
| 365.49 | 5.46 | 5.46 |
| 348.49 | 5.00 | 5.00 |
| 409.52 | 6.57 | 6.57 |
| 376.54 | 5.11 | 5.11 |
| 378.56 | 5.10 | 5.10 |
| 465.64 | 7.49 | 7.49 |
| 363.55 | 5.94 | 5.94 |
| 376.54 | 5.01 | 5.01 |
| 403.57 | 6.28 | 6.28 |
| 365.52 | 4.33 | 4.33 |
| 351.53 | 5.74 | 5.74 |
| 367.51 | 5.54 | 5.54 |
| 362.52 | 4.76 | 4.76 |
| 379.59 | 6.26 | 6.26 |
| 336.48 | 4.87 | 4.87 |
| 409.61 | 5.62 | 5.62 |
| 377.62 | 7.46 | 7.46 |
| 385.52 | 4.54 | 4.54 |
| 409.61 | 6.53 | 6.53 |
| 363.55 | 5.89 | 5.89 |
| 353.47 | 2.81 | 2.81 |
| 377.50 | 5.77 | 5.77 |
| 417.62 | 4.25 | 4.25 |
| 360.50 | 4.68 | 4.68 |
| 400.01 | 6.52 | 6.52 |
| 363.55 | 6.00 | 6.00 |
| 365.56 | 6.05 | 6.05 |
| 395.59 | 6.14 | 6.14 |
| 347.50 | 5.32 | 5.32 |
| 362.52 | 4.76 | 4.76 |
| 391.60 | 6.26 | 6.26 |
| 367.51 | 5.54 | 5.54 |
| 363.48 | 5.67 | 5.67 |
| 365.56 | 5.72 | 5.72 |
| 390.57 | 5.41 | 5.41 |
| 431.62 | 6.92 | 6.92 |
| 385.55 | 6.16 | 6.16 |
| 418.63 | 6.01 | 6.01 |
| 435.66 | 6.05 | 6.05 |
| 419.57 | 5.90 | 5.90 |
| 397.51 | 6.26 | 6.26 |
| 378.56 | 5.15 | 5.15 |
| 365.56 | 6.05 | 6.05 |
| 378.60 | 6.12 | 6.12 |
| 409.62 | 5.62 | 5.62 |
| 325.46 | 3.95 | 3.95 |
| 379.93 | 6.18 | 6.18 |
| 389.51 | 6.89 | 6.89 |
| 390.57 | 6.50 | 6.50 |
| 442.63 | 4.12 | 4.12 |
| 406.61 | 5.87 | 5.87 |
| 352.48 | 3.42 | 3.42 |
| 338.50 | 4.66 | 4.66 |
| 365.49 | 5.55 | 5.55 |
| 412.52 | 5.70 | 5.70 |
| 376.54 | 5.07 | 5.07 |
| 365.56 | 5.87 | 5.87 |
| 376.54 | 5.07 | 5.07 |
| 414.54 | 5.78 | 5.78 |
| 375.56 | 6.24 | 6.24 |
| 409.62 | 5.62 | 5.62 |
| 380.58 | 5.56 | 5.56 |
| 334.46 | 4.79 | 4.79 |
| 379.59 | 6.11 | 6.11 |
| 340.51 | 3.97 | 3.97 |
| 379.55 | 4.80 | 4.80 |
| 383.55 | 6.01 | 6.01 |
| 365.56 | 5.79 | 5.79 |
| 425.56 | 7.18 | 7.18 |
| 449.64 | 5.73 | 5.73 |
| 375.56 | 6.24 | 6.24 |
| 397.56 | 5.05 | 5.05 |
| 363.50 | 4.53 | 4.53 |
| 355.50 | 5.23 | 5.23 |
| 379.48 | 4.92 | 4.92 |
| 379.59 | 6.11 | 6.11 |
| 340.51 | 3.97 | 3.97 |
| 336.48 | 4.58 | 4.58 |
| 364.58 | 5.71 | 5.71 |
| 361.57 | 6.99 | 6.99 |
| 406.57 | 5.46 | 5.46 |
| 337.51 | 5.09 | 5.09 |
| 357.50 | 5.69 | 5.69 |
| 426.63 | 4.96 | 4.96 |
| 404.60 | 5.67 | 5.67 |
| 365.52 | 4.37 | 4.37 |
| 415.57 | 6.66 | 6.66 |
| 352.52 | 5.31 | 5.31 |
| 374.53 | 4.62 | 4.62 |
| 349.48 | 3.94 | 3.94 |
| 376.54 | 5.45 | 5.45 |
| 394.56 | 5.09 | 5.09 |
| 376.54 | 4.99 | 4.99 |
| 380.53 | 5.23 | 5.23 |
| 376.55 | 6.80 | 6.80 |
| 479.66 | 7.80 | 7.80 |
| 400.01 | 6.52 | 6.52 |
| 415.57 | 6.66 | 6.66 |
| 419.61 | 6.53 | 6.53 |
| 383.48 | 5.69 | 5.69 |
| 369.50 | 6.51 | 6.51 |
| 463.62 | 4.86 | 4.86 |
| 324.47 | 4.56 | 4.56 |
| 381.54 | 5.85 | 5.85 |
| 388.56 | 5.46 | 5.46 |
| 391.56 | 5.97 | 5.97 |
| 364.58 | 5.86 | 5.86 |
| 329.49 | 6.12 | 6.12 |
| 351.49 | 4.02 | 4.02 |
| 375.56 | 6.17 | 6.17 |
| 386.54 | 6.03 | 6.03 |
| 351.49 | 4.02 | 4.02 |
| 434.67 | 6.65 | 6.65 |
| 349.52 | 5.69 | 5.69 |
| 387.57 | 6.24 | 6.24 |
| 362.52 | 4.86 | 4.86 |
| 405.56 | 6.38 | 6.38 |
| 388.56 | 5.27 | 5.27 |
| 380.51 | 4.71 | 4.71 |
| 434.62 | 5.89 | 5.89 |
| 363.55 | 5.79 | 5.79 |
| 430.64 | 6.32 | 6.32 |
| 472.67 | 6.21 | 6.21 |
| 363.55 | 6.44 | 6.44 |
| 390.57 | 5.33 | 5.33 |
| 410.51 | 5.62 | 5.62 |
| 418.58 | 6.07 | 6.07 |
| 363.55 | 5.93 | 5.93 |
| 349.52 | 5.40 | 5.40 |
| 384.01 | 7.55 | 7.55 |
| 392.59 | 5.41 | 5.41 |
| 381.54 | 5.93 | 5.93 |
| 399.55 | 4.98 | 4.98 |
| 343.47 | 5.30 | 5.30 |
| 357.49 | 6.36 | 6.36 |
| 409.57 | 5.67 | 5.67 |
| 377.57 | 6.03 | 6.03 |
| 333.52 | 6.43 | 6.43 |
| 392.59 | 5.64 | 5.64 |
| 351.49 | 4.02 | 4.02 |
| 352.52 | 5.00 | 5.00 |
| 341.50 | 4.13 | 4.13 |
| 381.54 | 5.85 | 5.85 |
| 359.51 | 5.77 | 5.77 |
| 339.48 | 4.05 | 4.05 |
| 363.50 | 4.29 | 4.29 |
| 355.53 | 4.79 | 4.79 |
| 363.48 | 5.67 | 5.67 |
| 381.95 | 5.97 | 5.97 |
| 405.58 | 6.28 | 6.28 |
| 357.50 | 5.55 | 5.55 |
| 390.57 | 5.76 | 5.76 |
| 376.54 | 5.02 | 5.02 |
| 395.59 | 6.14 | 6.14 |
| 381.56 | 5.75 | 5.75 |
| 406.61 | 5.96 | 5.96 |
| 430.64 | 6.24 | 6.24 |
| 383.55 | 5.86 | 5.86 |
| 395.54 | 5.28 | 5.28 |
| 466.63 | 6.89 | 6.89 |
| 442.63 | 4.12 | 4.12 |
| 353.55 | 5.57 | 5.57 |
| 435.68 | 5.89 | 5.89 |
| 388.56 | 5.33 | 5.33 |
| 351.54 | 4.84 | 4.84 |
| 346.47 | 4.92 | 4.92 |
| 352.48 | 3.42 | 3.42 |
| 380.51 | 5.20 | 5.20 |
| 392.54 | 4.77 | 4.77 |
| 390.62 | 6.14 | 6.14 |
| 415.60 | 4.17 | 4.17 |
| 412.52 | 6.00 | 6.00 |
| 379.59 | 6.44 | 6.44 |
| 377.57 | 5.96 | 5.96 |
| 416.61 | 5.93 | 5.93 |
| 395.59 | 6.14 | 6.14 |
| 401.55 | 5.18 | 5.18 |
| 350.55 | 5.44 | 5.44 |
| 347.50 | 5.01 | 5.01 |
| 392.52 | 4.76 | 4.76 |
| 369.50 | 6.67 | 6.67 |
| 354.50 | 3.50 | 3.50 |
| 376.54 | 6.26 | 6.26 |
| 377.53 | 4.72 | 4.72 |
| 373.54 | 6.16 | 6.16 |
| 361.53 | 5.85 | 5.85 |
| 381.54 | 5.62 | 5.62 |
| 363.51 | 4.16 | 4.16 |
| 376.54 | 5.07 | 5.07 |
| 352.48 | 3.42 | 3.42 |
| 371.52 | 6.75 | 6.75 |
| 360.50 | 5.11 | 5.11 |
| 359.51 | 5.63 | 5.63 |
| 458.57 | 6.56 | 6.56 |
| 363.55 | 5.79 | 5.79 |
| 379.52 | 6.05 | 6.05 |
| 375.49 | 5.69 | 5.69 |
| 327.47 | 3.74 | 3.74 |
| 376.54 | 5.07 | 5.07 |
| 411.54 | 6.79 | 6.79 |
| 396.53 | 4.44 | 4.44 |
| 440.58 | 6.48 | 6.48 |
| 363.55 | 5.71 | 5.71 |
| 380.51 | 5.82 | 5.82 |
| 377.50 | 5.60 | 5.60 |
| 365.56 | 6.13 | 6.13 |
| 417.62 | 4.25 | 4.25 |
| 371.52 | 5.77 | 5.77 |
| 345.49 | 5.22 | 5.22 |
| 377.50 | 5.91 | 5.91 |
| 381.56 | 4.84 | 4.84 |
| 382.55 | 4.23 | 4.23 |
| 375.56 | 5.48 | 5.48 |
| 355.49 | 2.90 | 2.90 |
| 379.52 | 5.99 | 5.99 |
| 365.52 | 5.27 | 5.27 |
| 376.54 | 6.11 | 6.11 |
| 361.53 | 5.92 | 5.92 |
| 364.53 | 5.08 | 5.08 |
| 420.64 | 6.26 | 6.26 |
| 424.59 | 4.57 | 4.57 |
| 383.55 | 6.01 | 6.01 |
| 378.52 | 5.15 | 5.15 |
| 409.52 | 6.71 | 6.71 |
| 404.55 | 5.03 | 5.03 |
| 446.56 | 6.16 | 6.16 |
| 349.56 | 6.90 | 6.90 |
| 359.51 | 5.77 | 5.77 |
| 379.54 | 5.70 | 5.70 |
| 363.51 | 4.16 | 4.16 |
| 414.55 | 5.05 | 5.05 |
| 375.51 | 4.75 | 4.75 |
| 363.55 | 5.79 | 5.79 |
| 403.51 | 4.68 | 4.68 |
| 354.50 | 3.50 | 3.50 |
| 376.59 | 6.24 | 6.24 |
| 421.58 | 6.92 | 6.92 |
| 378.60 | 6.01 | 6.01 |
| 394.56 | 4.86 | 4.86 |
| 347.55 | 6.74 | 6.74 |
| 351.53 | 5.74 | 5.74 |
| 389.51 | 6.06 | 6.06 |
| 360.50 | 5.79 | 5.79 |
| 361.53 | 5.71 | 5.71 |
| 423.60 | 7.00 | 7.00 |
| 363.48 | 5.52 | 5.52 |
| 399.53 | 6.34 | 6.34 |
| 367.51 | 5.54 | 5.54 |
| 374.53 | 5.36 | 5.36 |
| 392.59 | 5.62 | 5.62 |
| 362.52 | 4.98 | 4.98 |
| 365.56 | 5.87 | 5.87 |
| 377.53 | 5.33 | 5.33 |
| 419.61 | 5.73 | 5.73 |
| 381.56 | 5.75 | 5.75 |
| 374.53 | 5.27 | 5.27 |
| 375.49 | 5.83 | 5.83 |
| 422.61 | 5.63 | 5.63 |
| 376.54 | 5.07 | 5.07 |
| 375.56 | 5.95 | 5.95 |
| 361.53 | 5.72 | 5.72 |
| 361.53 | 6.00 | 6.00 |
| 369.55 | 4.81 | 4.81 |
| 451.61 | 7.18 | 7.18 |
| 405.58 | 6.19 | 6.19 |