Basic Information
ID: ALA3882750
Type: Binding
Description: Inhibition of Sprague-Dawley rat adrenal mitochondrial CYP11B assessed as decrease in conversion of 11-deoxycortisol to cortisol at 100 nM incubated for 60 mins by ELISA relative to control
Format: BAO_0000224
Organism: Rattus norvegicus
Strain: Sprague-Dawley
Target: Cytochrome P450 11B(ALA3988630)
Document: ALA3882724
Inhibition of Sprague-Dawley rat adrenal mitochondrial CYP11B assessed as decrease in conversion of 11-deoxycortisol to cortisol at 100 nM incubated for 60 mins by ELISA relative to control: 38
Activity Charts
Bioactivity
Activity Types for Assay ALA3882750
Inhibition
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 406.57 | 5.36 | 5.36 |
| 379.59 | 6.44 | 6.44 |
| 406.55 | 5.41 | 5.41 |
| 403.57 | 5.11 | 5.11 |
| 389.54 | 5.89 | 5.89 |
| 442.63 | 4.77 | 4.77 |
| 345.49 | 5.53 | 5.53 |
| 353.51 | 4.10 | 4.10 |
| 452.66 | 5.49 | 5.49 |
| 349.52 | 5.70 | 5.70 |
| 381.49 | 5.00 | 5.00 |
| 361.53 | 5.63 | 5.63 |
| 408.59 | 5.84 | 5.84 |
| 380.53 | 4.17 | 4.17 |
| 432.61 | 5.43 | 5.43 |
| 353.51 | 4.11 | 4.11 |
| 357.50 | 5.55 | 5.55 |
| 363.55 | 5.48 | 5.48 |
| 374.53 | 5.89 | 5.89 |
| 350.55 | 5.56 | 5.56 |
| 388.56 | 6.26 | 6.26 |
| 382.52 | 4.98 | 4.98 |
| 405.59 | 5.19 | 5.19 |
| 378.56 | 5.15 | 5.15 |
| 379.59 | 6.91 | 6.91 |
| 355.48 | 5.47 | 5.47 |
| 359.51 | 5.46 | 5.46 |
| 383.51 | 4.75 | 4.75 |
| 377.57 | 6.03 | 6.03 |
| 390.57 | 5.33 | 5.33 |
| 431.65 | 6.66 | 6.66 |
| 406.61 | 5.97 | 5.97 |
| 379.59 | 6.26 | 6.26 |
| 507.72 | 8.48 | 8.48 |
| 365.49 | 5.46 | 5.46 |
| 376.54 | 5.11 | 5.11 |
| 363.55 | 5.94 | 5.94 |
| 376.54 | 5.01 | 5.01 |
| 351.53 | 5.74 | 5.74 |
| 336.48 | 4.87 | 4.87 |
| 409.61 | 5.62 | 5.62 |
| 353.47 | 2.81 | 2.81 |
| 363.55 | 6.00 | 6.00 |
| 395.59 | 6.14 | 6.14 |
| 391.60 | 6.26 | 6.26 |
| 418.63 | 6.01 | 6.01 |
| 419.57 | 5.90 | 5.90 |
| 378.56 | 5.15 | 5.15 |
| 365.56 | 6.05 | 6.05 |
| 409.62 | 5.62 | 5.62 |
| 389.51 | 6.89 | 6.89 |
| 365.49 | 5.55 | 5.55 |
| 409.62 | 5.62 | 5.62 |
| 352.52 | 5.31 | 5.31 |
| 374.53 | 4.62 | 4.62 |
| 376.54 | 5.45 | 5.45 |
| 380.53 | 5.23 | 5.23 |
| 400.01 | 6.52 | 6.52 |
| 463.62 | 4.86 | 4.86 |
| 324.47 | 4.56 | 4.56 |
| 364.58 | 5.86 | 5.86 |
| 351.49 | 4.02 | 4.02 |
| 375.56 | 6.17 | 6.17 |
| 434.67 | 6.65 | 6.65 |
| 362.52 | 4.86 | 4.86 |
| 388.56 | 5.27 | 5.27 |
| 384.01 | 7.55 | 7.55 |
| 392.59 | 5.41 | 5.41 |
| 343.47 | 5.30 | 5.30 |
| 409.57 | 5.67 | 5.67 |
| 333.52 | 6.43 | 6.43 |
| 339.48 | 4.05 | 4.05 |
| 390.57 | 5.76 | 5.76 |
| 395.59 | 6.14 | 6.14 |
| 435.68 | 5.89 | 5.89 |
| 351.54 | 4.84 | 4.84 |
| 377.57 | 5.96 | 5.96 |
| 347.50 | 5.01 | 5.01 |
| 369.50 | 6.67 | 6.67 |
| 360.50 | 5.11 | 5.11 |
| 411.54 | 6.79 | 6.79 |
| 396.53 | 4.44 | 4.44 |
| 380.51 | 5.82 | 5.82 |
| 365.56 | 6.13 | 6.13 |
| 417.62 | 4.25 | 4.25 |
| 375.56 | 5.48 | 5.48 |
| 365.52 | 5.27 | 5.27 |
| 361.53 | 5.92 | 5.92 |
| 420.64 | 6.26 | 6.26 |
| 404.55 | 5.03 | 5.03 |
| 349.56 | 6.90 | 6.90 |
| 359.51 | 5.77 | 5.77 |
| 363.55 | 5.79 | 5.79 |
| 421.58 | 6.92 | 6.92 |
| 394.56 | 4.86 | 4.86 |
| 351.53 | 5.74 | 5.74 |
| 362.52 | 4.98 | 4.98 |
| 365.56 | 5.87 | 5.87 |
| 361.53 | 5.72 | 5.72 |
| 361.53 | 6.00 | 6.00 |