Basic Information
ID: ALA3882752
Type: Binding
Description: Inhibition of CYP17 in human testicular microsomes using 17alpha-hydroxypregnenolone as substrate assessed as decrease in DHEA levels at 1 nM after 90 mins by ELISA relative to control
Format: BAO_0000019
Organism: Homo sapiens
Tissue: Testis
Subcellular Fraction: Microsomes
Target: Cytochrome P450 17A1(ALA3522)
Document: ALA3882724
Inhibition of CYP17 in human testicular microsomes using 17alpha-hydroxypregnenolone as substrate assessed as decrease in DHEA levels at 1 nM after 90 mins by ELISA relative to control: 38
Activity Charts
Bioactivity
Activity Types for Assay ALA3882752
IC50
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 351.54 | 4.57 | 4.57 |
| 337.47 | 3.93 | 3.93 |
| 395.55 | 5.02 | 5.02 |
| 406.55 | 5.41 | 5.41 |
| 441.59 | 7.14 | 7.14 |
| 379.59 | 5.97 | 5.97 |
| 442.63 | 4.77 | 4.77 |
| 397.51 | 6.54 | 6.54 |
| 479.66 | 7.80 | 7.80 |
| 375.52 | 4.42 | 4.42 |
| 381.49 | 5.00 | 5.00 |
| 437.60 | 5.86 | 5.86 |
| 446.64 | 6.85 | 6.85 |
| 446.64 | 5.94 | 5.94 |
| 345.49 | 5.38 | 5.38 |
| 390.57 | 5.54 | 5.54 |
| 363.55 | 5.79 | 5.79 |
| 359.51 | 5.92 | 5.92 |
| 357.50 | 5.55 | 5.55 |
| 401.50 | 4.89 | 4.89 |
| 419.61 | 5.58 | 5.58 |
| 374.53 | 5.89 | 5.89 |
| 392.54 | 5.07 | 5.07 |
| 414.55 | 5.05 | 5.05 |
| 377.57 | 6.36 | 6.36 |
| 363.55 | 5.79 | 5.79 |
| 382.52 | 4.98 | 4.98 |
| 405.59 | 5.19 | 5.19 |
| 364.53 | 4.98 | 4.98 |
| 406.61 | 5.97 | 5.97 |
| 377.57 | 6.18 | 6.18 |
| 467.61 | 6.97 | 6.97 |
| 424.54 | 5.87 | 5.87 |
| 410.61 | 5.06 | 5.06 |
| 376.54 | 5.01 | 5.01 |
| 403.57 | 6.28 | 6.28 |
| 379.59 | 6.26 | 6.26 |
| 409.61 | 5.62 | 5.62 |
| 363.48 | 5.67 | 5.67 |
| 365.56 | 5.72 | 5.72 |
| 385.55 | 6.16 | 6.16 |
| 378.56 | 5.15 | 5.15 |
| 379.93 | 6.18 | 6.18 |
| 389.51 | 6.89 | 6.89 |
| 390.57 | 6.50 | 6.50 |
| 442.63 | 4.12 | 4.12 |
| 365.49 | 5.55 | 5.55 |
| 412.52 | 5.70 | 5.70 |
| 376.54 | 5.07 | 5.07 |
| 449.64 | 5.73 | 5.73 |
| 375.56 | 6.24 | 6.24 |
| 363.50 | 4.53 | 4.53 |
| 336.48 | 4.58 | 4.58 |
| 357.50 | 5.69 | 5.69 |
| 426.63 | 4.96 | 4.96 |
| 352.52 | 5.31 | 5.31 |
| 376.54 | 4.99 | 4.99 |
| 479.66 | 7.80 | 7.80 |
| 400.01 | 6.52 | 6.52 |
| 415.57 | 6.66 | 6.66 |
| 419.61 | 6.53 | 6.53 |
| 381.54 | 5.85 | 5.85 |
| 388.56 | 5.46 | 5.46 |
| 386.54 | 6.03 | 6.03 |
| 388.56 | 5.27 | 5.27 |
| 380.51 | 4.71 | 4.71 |
| 363.55 | 5.79 | 5.79 |
| 390.57 | 5.33 | 5.33 |
| 410.51 | 5.62 | 5.62 |
| 399.55 | 4.98 | 4.98 |
| 341.50 | 4.13 | 4.13 |
| 359.51 | 5.77 | 5.77 |
| 430.64 | 6.24 | 6.24 |
| 383.55 | 5.86 | 5.86 |
| 353.55 | 5.57 | 5.57 |
| 346.47 | 4.92 | 4.92 |
| 380.51 | 5.20 | 5.20 |
| 350.55 | 5.44 | 5.44 |
| 369.50 | 6.67 | 6.67 |
| 361.53 | 5.85 | 5.85 |
| 360.50 | 5.11 | 5.11 |
| 359.51 | 5.63 | 5.63 |
| 458.57 | 6.56 | 6.56 |
| 376.54 | 5.07 | 5.07 |
| 411.54 | 6.79 | 6.79 |
| 396.53 | 4.44 | 4.44 |
| 363.55 | 5.71 | 5.71 |
| 365.56 | 6.13 | 6.13 |
| 417.62 | 4.25 | 4.25 |
| 371.52 | 5.77 | 5.77 |
| 409.52 | 6.71 | 6.71 |
| 389.51 | 6.06 | 6.06 |
| 363.48 | 5.52 | 5.52 |
| 367.51 | 5.54 | 5.54 |
| 392.59 | 5.62 | 5.62 |
| 375.49 | 5.83 | 5.83 |
| 375.56 | 5.95 | 5.95 |
| 361.53 | 6.00 | 6.00 |
| 451.61 | 7.18 | 7.18 |
| 405.58 | 6.19 | 6.19 |