Basic Information
ID: ALA3882753
Type: Binding
Description: Inhibition of human CYP21 transfected in HEK293 cells assessed as decrease in conversion of progesterone to 11-deoxycorticosterone preincubated for 5 hrs followed by progesterone addition measured after 20 hrs by ELISA
Format: BAO_0000219
Organism: Homo sapiens
Cell type: HEK293
Target: Cytochrome P450 21(ALA2759)
Document: ALA3882724
Inhibition of human CYP21 transfected in HEK293 cells assessed as decrease in conversion of progesterone to 11-deoxycorticosterone preincubated for 5 hrs followed by progesterone addition measured after 20 hrs by ELISA: 38
Activity Charts
Bioactivity
Activity Types for Assay ALA3882753
Inhibition
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 347.50 | 5.61 | 5.61 |
| 349.52 | 5.40 | 5.40 |
| 351.54 | 4.57 | 4.57 |
| 371.52 | 5.92 | 5.92 |
| 406.57 | 5.36 | 5.36 |
| 337.47 | 3.93 | 3.93 |
| 395.55 | 5.02 | 5.02 |
| 383.96 | 6.05 | 6.05 |
| 379.59 | 5.97 | 5.97 |
| 351.49 | 4.32 | 4.32 |
| 452.66 | 5.49 | 5.49 |
| 381.49 | 5.00 | 5.00 |
| 378.49 | 4.82 | 4.82 |
| 376.50 | 4.19 | 4.19 |
| 408.59 | 4.98 | 4.98 |
| 373.54 | 6.00 | 6.00 |
| 418.63 | 6.32 | 6.32 |
| 390.57 | 5.54 | 5.54 |
| 401.50 | 4.89 | 4.89 |
| 380.51 | 5.20 | 5.20 |
| 377.57 | 6.36 | 6.36 |
| 459.66 | 6.29 | 6.29 |
| 382.52 | 4.98 | 4.98 |
| 364.53 | 4.98 | 4.98 |
| 390.57 | 5.33 | 5.33 |
| 359.51 | 5.46 | 5.46 |
| 415.57 | 6.66 | 6.66 |
| 359.47 | 5.19 | 5.19 |
| 431.65 | 6.66 | 6.66 |
| 406.61 | 5.97 | 5.97 |
| 379.59 | 6.26 | 6.26 |
| 410.61 | 5.06 | 5.06 |
| 348.49 | 5.00 | 5.00 |
| 378.56 | 5.10 | 5.10 |
| 376.54 | 5.01 | 5.01 |
| 403.57 | 6.28 | 6.28 |
| 409.61 | 5.62 | 5.62 |
| 385.52 | 4.54 | 4.54 |
| 417.62 | 4.25 | 4.25 |
| 400.01 | 6.52 | 6.52 |
| 395.59 | 6.14 | 6.14 |
| 367.51 | 5.54 | 5.54 |
| 409.62 | 5.62 | 5.62 |
| 389.51 | 6.89 | 6.89 |
| 390.57 | 6.50 | 6.50 |
| 412.52 | 5.70 | 5.70 |
| 365.56 | 5.87 | 5.87 |
| 379.59 | 6.11 | 6.11 |
| 336.48 | 4.58 | 4.58 |
| 406.57 | 5.46 | 5.46 |
| 426.63 | 4.96 | 4.96 |
| 415.57 | 6.66 | 6.66 |
| 374.53 | 4.62 | 4.62 |
| 376.54 | 4.99 | 4.99 |
| 376.55 | 6.80 | 6.80 |
| 400.01 | 6.52 | 6.52 |
| 419.61 | 6.53 | 6.53 |
| 383.48 | 5.69 | 5.69 |
| 369.50 | 6.51 | 6.51 |
| 388.56 | 5.46 | 5.46 |
| 329.49 | 6.12 | 6.12 |
| 375.56 | 6.17 | 6.17 |
| 351.49 | 4.02 | 4.02 |
| 387.57 | 6.24 | 6.24 |
| 472.67 | 6.21 | 6.21 |
| 410.51 | 5.62 | 5.62 |
| 418.58 | 6.07 | 6.07 |
| 399.55 | 4.98 | 4.98 |
| 377.57 | 6.03 | 6.03 |
| 352.52 | 5.00 | 5.00 |
| 381.54 | 5.85 | 5.85 |
| 381.95 | 5.97 | 5.97 |
| 466.63 | 6.89 | 6.89 |
| 435.68 | 5.89 | 5.89 |
| 380.51 | 5.20 | 5.20 |
| 415.60 | 4.17 | 4.17 |
| 416.61 | 5.93 | 5.93 |
| 350.55 | 5.44 | 5.44 |
| 347.50 | 5.01 | 5.01 |
| 369.50 | 6.67 | 6.67 |
| 376.54 | 6.26 | 6.26 |
| 381.54 | 5.62 | 5.62 |
| 360.50 | 5.11 | 5.11 |
| 359.51 | 5.63 | 5.63 |
| 379.52 | 6.05 | 6.05 |
| 375.49 | 5.69 | 5.69 |
| 376.54 | 5.07 | 5.07 |
| 363.55 | 5.71 | 5.71 |
| 417.62 | 4.25 | 4.25 |
| 371.52 | 5.77 | 5.77 |
| 379.52 | 5.99 | 5.99 |
| 376.54 | 6.11 | 6.11 |
| 421.58 | 6.92 | 6.92 |
| 363.48 | 5.52 | 5.52 |
| 392.59 | 5.62 | 5.62 |
| 362.52 | 4.98 | 4.98 |
| 365.56 | 5.87 | 5.87 |
| 374.53 | 5.27 | 5.27 |
| 376.54 | 5.07 | 5.07 |
| 375.56 | 5.95 | 5.95 |