Basic Information
ID: ALA3882754
Type: Binding
Description: Inhibition of His6-tagged JNK2 (unknown origin) assessed as reduction in c-Jun phosphorylation using GST-c-Jun (1 to 79 residues) and [gamma32P]ATP incubated for 1 hr by scintillation counting assay
Organism: Homo sapiens
Activity Charts
Bioactivity
Activity Types for Assay ALA3882754
IC50
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 239.23 | 3.14 | 3.14 |
| 370.37 | 3.86 | 3.86 |
| 388.48 | 3.88 | 3.88 |
| 283.31 | 3.07 | 3.07 |
| 337.38 | 1.83 | 1.83 |
| 294.29 | 2.74 | 2.74 |
| 339.38 | 2.42 | 2.42 |
| 400.49 | 4.92 | 4.92 |
| 402.46 | 3.38 | 3.38 |
| 387.40 | 4.19 | 4.19 |
| 210.24 | 2.94 | 2.94 |
| 278.29 | 3.76 | 3.76 |
| 394.44 | 4.20 | 4.20 |
| 389.46 | 2.30 | 2.30 |
| 365.37 | 3.26 | 3.26 |
| 305.30 | 2.74 | 2.74 |
| 303.37 | 4.14 | 4.14 |
| 324.38 | 2.27 | 2.27 |
| 209.25 | 2.81 | 2.81 |
| 356.36 | 4.22 | 4.22 |
| 340.36 | 2.36 | 2.36 |
| 381.40 | 3.66 | 3.66 |
| 417.52 | 3.60 | 3.60 |
| 361.38 | 4.63 | 4.63 |
| 318.36 | 4.38 | 4.38 |
| 408.47 | 3.99 | 3.99 |
| 348.41 | 3.27 | 3.27 |
| 388.43 | 3.02 | 3.02 |
| 368.40 | 3.99 | 3.99 |
| 467.53 | 3.75 | 3.75 |
| 277.29 | 1.99 | 1.99 |
| 347.35 | 4.33 | 4.33 |
| 477.57 | 4.41 | 4.41 |
| 477.57 | 4.49 | 4.49 |
| 345.38 | 4.93 | 4.93 |
| 393.42 | 4.04 | 4.04 |
| 417.47 | 2.08 | 2.08 |
| 328.35 | 4.91 | 4.91 |
| 322.33 | 2.43 | 2.43 |
| 269.28 | 2.73 | 2.73 |
| 374.45 | 4.39 | 4.39 |
| 334.38 | 3.44 | 3.44 |
| 372.38 | 3.29 | 3.29 |
| 324.36 | 2.41 | 2.41 |
| 297.31 | 2.35 | 2.35 |
| 295.30 | 2.10 | 2.10 |
| 275.74 | 2.82 | 2.82 |
| 284.29 | 3.55 | 3.55 |
| 375.44 | 2.31 | 2.31 |
| 337.36 | 3.08 | 3.08 |
| 329.29 | 4.03 | 4.03 |
| 277.28 | 3.08 | 3.08 |
| 398.47 | 4.24 | 4.24 |
| 389.39 | 4.25 | 4.25 |
| 296.72 | 3.06 | 3.06 |
| 326.38 | 2.66 | 2.66 |
| 277.25 | 3.83 | 3.83 |
| 420.48 | 4.43 | 4.43 |
| 364.45 | 3.19 | 3.19 |
| 434.50 | 5.15 | 5.15 |
| 305.30 | 2.71 | 2.71 |
| 370.38 | 3.54 | 3.54 |
| 276.30 | 2.60 | 2.60 |
| 293.35 | 3.54 | 3.54 |
| 332.34 | 4.02 | 4.02 |
| 346.37 | 3.69 | 3.69 |
| 317.38 | 4.23 | 4.23 |
| 341.37 | 4.18 | 4.18 |
| 349.40 | 2.35 | 2.35 |
| 348.37 | 2.60 | 2.60 |
| 374.38 | 3.72 | 3.72 |
| 311.35 | 4.17 | 4.17 |
| 389.39 | 4.41 | 4.41 |
| 321.36 | 4.28 | 4.28 |
| 391.44 | 2.12 | 2.12 |
| 312.34 | 3.56 | 3.56 |
| 371.38 | 4.53 | 4.53 |
| 463.55 | 4.86 | 4.86 |
| 319.32 | 2.79 | 2.79 |
| 276.30 | 2.60 | 2.60 |
| 390.45 | 2.73 | 2.73 |
| 410.44 | 4.28 | 4.28 |
| 367.40 | 4.17 | 4.17 |
| 304.36 | 3.53 | 3.53 |
| 369.40 | 4.74 | 4.74 |
| 252.28 | 1.91 | 1.91 |
| 309.34 | 3.61 | 3.61 |
| 348.41 | 2.96 | 2.96 |
| 415.84 | 4.32 | 4.32 |
| 302.30 | 3.16 | 3.16 |
| 505.63 | 5.05 | 5.05 |
| 331.35 | 4.62 | 4.62 |
| 394.44 | 4.58 | 4.58 |
| 346.35 | 3.17 | 3.17 |
| 262.23 | 4.25 | 4.25 |
| 384.44 | 4.07 | 4.07 |
| 370.39 | 4.40 | 4.40 |
| 351.34 | 3.17 | 3.17 |
| 410.44 | 3.69 | 3.69 |
| 287.33 | 3.52 | 3.52 |
| 372.43 | 4.14 | 4.14 |
| 387.45 | 2.40 | 2.40 |
| 346.37 | 3.69 | 3.69 |
| 318.37 | 3.62 | 3.62 |
| 332.34 | 4.02 | 4.02 |
| 438.41 | 4.53 | 4.53 |
| 337.31 | 2.78 | 2.78 |
| 370.41 | 3.51 | 3.51 |
| 370.37 | 3.86 | 3.86 |
| 287.32 | 3.48 | 3.48 |
| 391.48 | 3.14 | 3.14 |
| 401.47 | 2.97 | 2.97 |
| 391.39 | 2.30 | 2.30 |
| 350.40 | 3.26 | 3.26 |
| 358.41 | 3.30 | 3.30 |
| 254.26 | 3.57 | 3.57 |
| 413.48 | 3.58 | 3.58 |
| 284.29 | 3.39 | 3.39 |
| 348.37 | 2.33 | 2.33 |
| 323.33 | 3.21 | 3.21 |
| 337.38 | 4.68 | 4.68 |
| 419.46 | 2.82 | 2.82 |
| 376.44 | 4.14 | 4.14 |
| 394.44 | 3.95 | 3.95 |
| 253.26 | 2.03 | 2.03 |
| 488.42 | 3.36 | 3.36 |
| 267.32 | 3.08 | 3.08 |
| 420.48 | 4.43 | 4.43 |
| 472.60 | 3.29 | 3.29 |
| 380.41 | 4.27 | 4.27 |
| 415.50 | 3.83 | 3.83 |
| 381.40 | 3.66 | 3.66 |
| 349.35 | 1.73 | 1.73 |
| 364.43 | 4.00 | 4.00 |
| 341.34 | 2.96 | 2.96 |
| 359.36 | 5.45 | 5.45 |
| 361.41 | 2.52 | 2.52 |
| 278.28 | 2.12 | 2.12 |
| 323.38 | 2.75 | 2.75 |
| 454.49 | 4.32 | 4.32 |
| 449.30 | 5.57 | 5.57 |
| 436.48 | 3.40 | 3.40 |
| 271.25 | 2.49 | 2.49 |
| 380.41 | 4.27 | 4.27 |
| 312.34 | 3.56 | 3.56 |
| 381.40 | 3.66 | 3.66 |
| 416.49 | 2.20 | 2.20 |
| 402.43 | 4.04 | 4.04 |
| 292.30 | 2.42 | 2.42 |
| 227.22 | 1.92 | 1.92 |
| 436.48 | 3.40 | 3.40 |
| 357.37 | 4.18 | 4.18 |
| 346.37 | 3.69 | 3.69 |
| 375.36 | 4.32 | 4.32 |
| 292.30 | 2.42 | 2.42 |
| 363.42 | 2.27 | 2.27 |
| 360.42 | 4.14 | 4.14 |
| 329.36 | 4.19 | 4.19 |
| 382.44 | 2.82 | 2.82 |
| 439.30 | 4.82 | 4.82 |
| 268.31 | 2.47 | 2.47 |
| 364.36 | 5.15 | 5.15 |
| 285.31 | 2.75 | 2.75 |
| 469.52 | 4.15 | 4.15 |
| 293.31 | 3.46 | 3.46 |
| 420.48 | 3.91 | 3.91 |
| 431.50 | 2.56 | 2.56 |
| 374.45 | 3.79 | 3.79 |
| 324.34 | 1.91 | 1.91 |
| 314.35 | 3.88 | 3.88 |
| 296.26 | 2.71 | 2.71 |
| 383.42 | 3.83 | 3.83 |
| 369.40 | 3.44 | 3.44 |
| 348.37 | 2.60 | 2.60 |
| 295.32 | 3.72 | 3.72 |
| 381.40 | 3.66 | 3.66 |
| 320.36 | 2.35 | 2.35 |
| 280.33 | 2.39 | 2.39 |
| 363.43 | 2.74 | 2.74 |
| 362.43 | 3.66 | 3.66 |
| 400.44 | 3.52 | 3.52 |
| 420.48 | 4.30 | 4.30 |
| 323.29 | 2.13 | 2.13 |
| 332.34 | 4.02 | 4.02 |
| 347.35 | 4.33 | 4.33 |
| 362.39 | 2.81 | 2.81 |
| 286.30 | 2.14 | 2.14 |
| 406.45 | 4.67 | 4.67 |
| 363.43 | 2.74 | 2.74 |
| 333.39 | 4.36 | 4.36 |
| 388.40 | 3.98 | 3.98 |
| 388.40 | 3.65 | 3.65 |
| 331.35 | 4.62 | 4.62 |
| 280.27 | 2.55 | 2.55 |
| 385.40 | 4.73 | 4.73 |
| 278.28 | 2.12 | 2.12 |
| 328.38 | 4.06 | 4.06 |
| 289.29 | 4.29 | 4.29 |
| 292.30 | 2.42 | 2.42 |
| 398.38 | 3.43 | 3.43 |
| 283.29 | 3.54 | 3.54 |
| 372.43 | 3.69 | 3.69 |
| 320.35 | 2.68 | 2.68 |
| 412.43 | 4.08 | 4.08 |
| 212.23 | 3.37 | 3.37 |
| 382.39 | 3.06 | 3.06 |
| 408.47 | 4.51 | 4.51 |
| 358.41 | 3.15 | 3.15 |
| 301.31 | 3.76 | 3.76 |
| 362.41 | 3.75 | 3.75 |
| 321.31 | 4.21 | 4.21 |
| 263.26 | 1.80 | 1.80 |
| 371.40 | 2.90 | 2.90 |
| 315.35 | 4.93 | 4.93 |
| 279.34 | 3.45 | 3.45 |
| 335.37 | 3.04 | 3.04 |
| 406.39 | 3.79 | 3.79 |
| 322.35 | 2.87 | 2.87 |
| 408.47 | 4.51 | 4.51 |
| 389.39 | 4.00 | 4.00 |
| 371.40 | 2.90 | 2.90 |
| 318.36 | 4.38 | 4.38 |
| 379.40 | 3.25 | 3.25 |
| 355.37 | 3.35 | 3.35 |
| 380.41 | 4.27 | 4.27 |
| 255.25 | 2.47 | 2.47 |
| 365.37 | 3.26 | 3.26 |
| 316.38 | 5.15 | 5.15 |
| 348.41 | 3.09 | 3.09 |
| 251.29 | 3.19 | 3.19 |
| 349.35 | 1.99 | 1.99 |
| 388.40 | 3.65 | 3.65 |
| 359.36 | 4.63 | 4.63 |
| 363.38 | 2.39 | 2.39 |
| 340.36 | 3.23 | 3.23 |
| 361.38 | 4.23 | 4.23 |
| 304.36 | 3.08 | 3.08 |
| 344.38 | 3.36 | 3.36 |
| 332.38 | 4.65 | 4.65 |
| 326.33 | 1.97 | 1.97 |
| 321.77 | 4.17 | 4.17 |
| 330.36 | 4.79 | 4.79 |
| 370.37 | 3.86 | 3.86 |
| 367.38 | 3.31 | 3.31 |
| 424.51 | 4.77 | 4.77 |
| 290.33 | 2.53 | 2.53 |
| 318.34 | 2.97 | 2.97 |
| 398.40 | 4.41 | 4.41 |
| 300.36 | 4.81 | 4.81 |
| 313.33 | 2.48 | 2.48 |
| 277.29 | 2.72 | 2.72 |
| 403.45 | 2.29 | 2.29 |
| 447.46 | 4.32 | 4.32 |
| 270.27 | 1.97 | 1.97 |
| 252.24 | 2.00 | 2.00 |
| 346.39 | 3.75 | 3.75 |
| 374.45 | 3.49 | 3.49 |
| 402.50 | 4.27 | 4.27 |
| 375.36 | 4.32 | 4.32 |
| 317.35 | 3.49 | 3.49 |
| 360.42 | 4.00 | 4.00 |
| 275.32 | 3.32 | 3.32 |
| 377.38 | 3.54 | 3.54 |
| 255.30 | 3.80 | 3.80 |
| 361.41 | 2.52 | 2.52 |
| 477.57 | 3.97 | 3.97 |
| 321.36 | 4.11 | 4.11 |
| 358.41 | 3.82 | 3.82 |
| 386.46 | 4.08 | 4.08 |
| 422.85 | 4.30 | 4.30 |
| 346.39 | 3.61 | 3.61 |
| 279.30 | 2.26 | 2.26 |
| 382.39 | 3.06 | 3.06 |
| 357.37 | 2.98 | 2.98 |
| 299.29 | 3.16 | 3.16 |
| 408.42 | 3.84 | 3.84 |
| 381.40 | 3.66 | 3.66 |
| 437.51 | 4.33 | 4.33 |
| 350.40 | 3.78 | 3.78 |
| 378.41 | 2.99 | 2.99 |
| 294.34 | 4.14 | 4.14 |
| 307.23 | 4.16 | 4.16 |
| 376.35 | 4.53 | 4.53 |
| 416.49 | 3.22 | 3.22 |
| 360.39 | 4.85 | 4.85 |
| 404.86 | 4.16 | 4.16 |
| 261.28 | 2.06 | 2.06 |
| 344.38 | 2.91 | 2.91 |
| 391.46 | 3.27 | 3.27 |
| 330.18 | 4.32 | 4.32 |
| 425.45 | 3.82 | 3.82 |
| 371.36 | 3.26 | 3.26 |
| 332.34 | 4.02 | 4.02 |
| 354.40 | 2.39 | 2.39 |
| 528.42 | 4.47 | 4.47 |
| 310.36 | 2.39 | 2.39 |
| 315.35 | 4.93 | 4.93 |
| 355.38 | 4.82 | 4.82 |
| 363.40 | 3.08 | 3.08 |
| 308.36 | 4.23 | 4.23 |
| 395.43 | 3.78 | 3.78 |
| 317.37 | 4.55 | 4.55 |
| 348.41 | 2.96 | 2.96 |
| 389.39 | 4.41 | 4.41 |
| 412.43 | 4.34 | 4.34 |
| 362.39 | 2.39 | 2.39 |
| 367.42 | 3.65 | 3.65 |
| 375.36 | 4.32 | 4.32 |
| 356.36 | 4.22 | 4.22 |
| 348.39 | 3.58 | 3.58 |
| 303.33 | 2.95 | 2.95 |
| 291.31 | 3.02 | 3.02 |
| 348.32 | 2.04 | 2.04 |
| 362.44 | 3.35 | 3.35 |
| 327.32 | 2.57 | 2.57 |
| 354.39 | 2.39 | 2.39 |
| 414.86 | 4.92 | 4.92 |
| 332.34 | 4.02 | 4.02 |
| 402.50 | 4.27 | 4.27 |
| 431.54 | 4.45 | 4.45 |
| 294.29 | 3.73 | 3.73 |
| 291.31 | 3.34 | 3.34 |
| 251.25 | 2.61 | 2.61 |
| 436.50 | 5.48 | 5.48 |
| 229.19 | 2.73 | 2.73 |
| 438.50 | 3.72 | 3.72 |
| 226.25 | 3.68 | 3.68 |
| 335.36 | 3.35 | 3.35 |
| 371.36 | 3.26 | 3.26 |
| 389.39 | 4.41 | 4.41 |
| 288.31 | 2.91 | 2.91 |
| 227.24 | 2.95 | 2.95 |
| 417.52 | 4.06 | 4.06 |
| 366.38 | 2.22 | 2.22 |
| 463.55 | 4.02 | 4.02 |
| 208.26 | 3.54 | 3.54 |
| 358.36 | 3.58 | 3.58 |
| 306.29 | 2.14 | 2.14 |
| 410.44 | 3.69 | 3.69 |
| 319.36 | 4.11 | 4.11 |
| 384.44 | 3.90 | 3.90 |
| 391.44 | 2.12 | 2.12 |
| 263.26 | 1.80 | 1.80 |
| 282.27 | 3.47 | 3.47 |
| 395.43 | 3.34 | 3.34 |
| 336.37 | 3.22 | 3.22 |
| 313.36 | 4.48 | 4.48 |
| 376.44 | 3.57 | 3.57 |
| 312.34 | 3.86 | 3.86 |
| 392.44 | 3.11 | 3.11 |
| 313.29 | 2.18 | 2.18 |
| 295.73 | 3.67 | 3.67 |
| 289.29 | 4.29 | 4.29 |
| 424.46 | 4.42 | 4.42 |
| 391.48 | 2.54 | 2.54 |
| 332.34 | 4.02 | 4.02 |
| 362.41 | 3.64 | 3.64 |
| 278.29 | 3.76 | 3.76 |
| 362.39 | 2.53 | 2.53 |
| 360.42 | 3.54 | 3.54 |
| 269.26 | 3.15 | 3.15 |
| 410.44 | 3.69 | 3.69 |
| 298.32 | 2.06 | 2.06 |
| 346.37 | 4.20 | 4.20 |
| 317.35 | 3.53 | 3.53 |
| 415.50 | 3.23 | 3.23 |
| 279.28 | 3.15 | 3.15 |
| 350.38 | 2.30 | 2.30 |
| 345.34 | 4.41 | 4.41 |
| 295.73 | 3.67 | 3.67 |
| 301.35 | 3.83 | 3.83 |
| 408.47 | 4.59 | 4.59 |
| 346.39 | 3.15 | 3.15 |
| 422.49 | 4.68 | 4.68 |
| 328.38 | 4.06 | 4.06 |
| 374.38 | 3.72 | 3.72 |
| 268.31 | 2.47 | 2.47 |
| 256.24 | 3.07 | 3.07 |
| 312.35 | 2.45 | 2.45 |
| 267.29 | 2.34 | 2.34 |