Basic Information
ID: ALA3883066
Type: Binding
Description: Inhibition of recombinant human N-terminal His6-tagged EphB4 kinase domain (E605 to E890 residues) expressed in baculovirus using poly-AEKY as substrate after 150 mins in presence of gamma33P-ATP by liquid scintillation spectrometry
Organism: Homo sapiens
Activity Charts
Bioactivity
Activity Types for Assay ALA3883066
IC50
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 491.39 | 5.79 | 5.79 |
| 504.42 | 4.62 | 4.62 |
| 513.55 | 3.31 | 3.31 |
| 463.37 | 4.71 | 4.71 |
| 538.81 | 4.09 | 4.09 |
| 513.40 | 3.73 | 3.73 |
| 473.37 | 4.16 | 4.16 |
| 432.88 | 3.88 | 3.88 |
| 564.45 | 4.32 | 4.32 |
| 576.27 | 8.54 | 8.54 |
| 479.36 | 3.76 | 3.76 |
| 508.76 | 3.70 | 3.70 |
| 492.36 | 4.50 | 4.50 |
| 516.45 | 6.19 | 6.19 |
| 555.48 | 4.90 | 4.90 |
| 491.38 | 4.70 | 4.70 |
| 509.37 | 4.31 | 4.31 |
| 581.50 | 6.49 | 6.49 |
| 545.50 | 5.87 | 5.87 |
| 478.93 | 4.80 | 4.80 |
| 557.23 | 5.36 | 5.36 |
| 502.37 | 4.01 | 4.01 |
| 505.40 | 4.75 | 4.75 |
| 506.39 | 6.51 | 6.51 |
| 531.48 | 6.35 | 6.35 |
| 510.41 | 6.79 | 6.79 |
| 570.85 | 3.76 | 3.76 |
| 493.37 | 5.07 | 5.07 |
| 521.36 | 3.77 | 3.77 |
| 428.92 | 4.05 | 4.05 |
| 544.51 | 6.92 | 6.92 |
| 489.40 | 5.18 | 5.18 |
| 502.36 | 3.56 | 3.56 |
| 530.48 | 6.53 | 6.53 |
| 554.27 | 5.68 | 5.68 |
| 515.40 | 5.81 | 5.81 |
| 502.40 | 5.07 | 5.07 |
| 493.79 | 4.51 | 4.51 |
| 549.41 | 4.25 | 4.25 |
| 553.49 | 6.40 | 6.40 |
| 520.39 | 4.56 | 4.56 |
| 516.45 | 6.32 | 6.32 |
| 462.28 | 6.55 | 6.55 |
| 567.45 | 7.08 | 7.08 |
| 602.48 | 5.71 | 5.71 |
| 589.50 | 5.30 | 5.30 |
| 573.42 | 5.02 | 5.02 |
| 449.34 | 4.40 | 4.40 |
| 495.97 | 3.48 | 3.48 |
| 544.51 | 6.92 | 6.92 |
| 601.49 | 7.11 | 7.11 |
| 433.34 | 5.16 | 5.16 |
| 589.48 | 6.76 | 6.76 |
| 570.27 | 4.93 | 4.93 |
| 483.78 | 5.05 | 5.05 |
| 515.40 | 5.81 | 5.81 |
| 467.33 | 4.54 | 4.54 |
| 428.92 | 4.05 | 4.05 |
| 536.81 | 4.75 | 4.75 |
| 447.37 | 5.55 | 5.55 |
| 519.43 | 5.34 | 5.34 |
| 509.37 | 4.31 | 4.31 |
| 563.88 | 5.05 | 5.05 |
| 487.35 | 5.08 | 5.08 |
| 494.35 | 3.98 | 3.98 |
| 509.35 | 5.36 | 5.36 |
| 450.87 | 4.02 | 4.02 |
| 522.78 | 4.36 | 4.36 |
| 530.48 | 6.88 | 6.88 |
| 543.43 | 6.11 | 6.11 |
| 493.79 | 4.51 | 4.51 |
| 473.37 | 4.16 | 4.16 |
| 545.51 | 6.74 | 6.74 |
| 499.93 | 3.44 | 3.44 |
| 493.39 | 4.41 | 4.41 |
| 545.50 | 5.47 | 5.47 |
| 538.24 | 4.62 | 4.62 |
| 477.39 | 5.18 | 5.18 |
| 463.37 | 4.83 | 4.83 |
| 463.32 | 3.93 | 3.93 |
| 559.54 | 7.13 | 7.13 |
| 553.82 | 4.42 | 4.42 |
| 491.42 | 5.57 | 5.57 |
| 447.37 | 5.55 | 5.55 |
| 473.37 | 4.16 | 4.16 |
| 539.46 | 6.01 | 6.01 |
| 510.41 | 6.79 | 6.79 |
| 492.36 | 3.25 | 3.25 |
| 515.40 | 5.46 | 5.46 |
| 526.42 | 5.36 | 5.36 |
| 419.43 | 0.37 | 0.37 |
| 577.51 | 6.87 | 6.87 |
| 475.38 | 4.93 | 4.93 |
| 493.42 | 4.84 | 4.84 |
| 449.34 | 4.45 | 4.45 |
| 567.47 | 5.93 | 5.93 |
| 523.42 | 3.78 | 3.78 |
| 495.38 | 5.32 | 5.32 |
| 491.42 | 5.57 | 5.57 |
| 478.33 | 4.60 | 4.60 |
| 501.41 | 5.18 | 5.18 |
| 404.30 | 5.87 | 5.87 |
| 459.38 | 5.41 | 5.41 |
| 531.44 | 5.49 | 5.49 |
| 519.47 | 6.20 | 6.20 |
| 463.37 | 4.71 | 4.71 |
| 495.38 | 5.32 | 5.32 |
| 558.76 | 4.95 | 4.95 |
| 577.86 | 4.04 | 4.04 |
| 476.91 | 4.56 | 4.56 |
| 580.54 | 8.24 | 8.24 |
| 493.39 | 4.41 | 4.41 |
| 530.46 | 5.85 | 5.85 |
| 511.78 | 4.65 | 4.65 |
| 561.86 | 4.81 | 4.81 |
| 575.90 | 4.73 | 4.73 |
| 507.82 | 4.82 | 4.82 |
| 553.82 | 4.42 | 4.42 |
| 496.32 | 4.74 | 4.74 |
| 495.56 | 3.02 | 3.02 |
| 535.43 | 5.70 | 5.70 |
| 435.31 | 4.06 | 4.06 |
| 554.27 | 5.69 | 5.69 |
| 527.43 | 4.12 | 4.12 |
| 529.42 | 5.24 | 5.24 |
| 420.30 | 5.25 | 5.25 |
| 463.37 | 4.79 | 4.79 |
| 520.47 | 6.06 | 6.06 |
| 575.89 | 5.20 | 5.20 |
| 519.43 | 4.95 | 4.95 |
| 475.34 | 4.71 | 4.71 |
| 553.82 | 4.42 | 4.42 |
| 533.50 | 6.59 | 6.59 |
| 477.39 | 5.18 | 5.18 |
| 390.27 | 5.48 | 5.48 |
| 475.38 | 4.93 | 4.93 |
| 516.84 | 8.14 | 8.14 |
| 436.30 | 4.83 | 4.83 |
| 522.78 | 4.36 | 4.36 |
| 505.45 | 5.96 | 5.96 |
| 593.39 | 6.03 | 6.03 |
| 530.48 | 6.53 | 6.53 |
| 516.45 | 6.49 | 6.49 |
| 489.40 | 5.32 | 5.32 |
| 491.42 | 5.57 | 5.57 |
| 510.35 | 4.64 | 4.64 |
| 475.38 | 4.93 | 4.93 |
| 533.46 | 5.88 | 5.88 |
| 492.76 | 4.73 | 4.73 |
| 503.43 | 5.73 | 5.73 |
| 473.36 | 4.40 | 4.40 |
| 519.47 | 6.35 | 6.35 |
| 501.37 | 5.42 | 5.42 |
| 480.33 | 3.64 | 3.64 |
| 550.79 | 4.27 | 4.27 |
| 575.47 | 5.16 | 5.16 |
| 524.36 | 6.33 | 6.33 |
| 487.39 | 4.79 | 4.79 |
| 473.37 | 4.16 | 4.16 |
| 571.26 | 5.26 | 5.26 |
| 525.44 | 5.97 | 5.97 |
| 512.40 | 5.37 | 5.37 |
| 449.34 | 4.45 | 4.45 |
| 524.78 | 3.75 | 3.75 |
| 463.37 | 4.79 | 4.79 |
| 475.34 | 4.71 | 4.71 |
| 449.84 | 4.06 | 4.06 |
| 490.44 | 5.09 | 5.09 |
| 477.39 | 5.18 | 5.18 |
| 535.43 | 4.72 | 4.72 |
| 513.34 | 5.92 | 5.92 |
| 502.43 | 5.71 | 5.71 |
| 560.75 | 5.52 | 5.52 |
| 491.42 | 5.57 | 5.57 |
| 530.42 | 4.40 | 4.40 |
| 539.83 | 5.43 | 5.43 |
| 463.35 | 5.22 | 5.22 |
| 450.72 | 4.97 | 4.97 |
| 528.39 | 4.17 | 4.17 |
| 520.39 | 4.56 | 4.56 |
| 570.48 | 5.09 | 5.09 |
| 587.89 | 6.19 | 6.19 |
| 463.37 | 4.79 | 4.79 |
| 495.32 | 4.13 | 4.13 |
| 477.39 | 5.18 | 5.18 |
| 530.42 | 4.21 | 4.21 |
| 533.46 | 5.73 | 5.73 |
| 532.45 | 5.56 | 5.56 |
| 491.38 | 4.17 | 4.17 |
| 568.44 | 6.20 | 6.20 |
| 585.86 | 3.26 | 3.26 |
| 508.37 | 6.63 | 6.63 |
| 474.95 | 3.76 | 3.76 |
| 517.44 | 5.13 | 5.13 |
| 483.78 | 5.05 | 5.05 |
| 503.43 | 5.73 | 5.73 |
| 517.37 | 4.48 | 4.48 |
| 508.76 | 3.70 | 3.70 |
| 583.47 | 5.55 | 5.55 |
| 506.37 | 4.17 | 4.17 |
| 493.79 | 4.51 | 4.51 |
| 488.40 | 5.37 | 5.37 |
| 516.45 | 6.19 | 6.19 |
| 494.34 | 6.32 | 6.32 |
| 492.91 | 3.79 | 3.79 |
| 475.38 | 4.95 | 4.95 |
| 540.77 | 4.84 | 4.84 |
| 491.42 | 5.57 | 5.57 |
| 538.85 | 5.07 | 5.07 |
| 558.42 | 5.21 | 5.21 |
| 506.37 | 4.17 | 4.17 |
| 519.47 | 6.20 | 6.20 |
| 579.79 | 8.49 | 8.49 |
| 432.88 | 3.88 | 3.88 |
| 502.43 | 6.15 | 6.15 |
| 512.35 | 2.52 | 2.52 |
| 450.32 | 5.22 | 5.22 |
| 535.47 | 5.32 | 5.32 |
| 550.45 | 7.62 | 7.62 |
| 532.47 | 4.86 | 4.86 |
| 545.51 | 6.74 | 6.74 |
| 449.34 | 4.40 | 4.40 |
| 432.88 | 3.88 | 3.88 |
| 487.35 | 5.08 | 5.08 |
| 404.30 | 6.01 | 6.01 |
| 559.52 | 5.86 | 5.86 |
| 477.39 | 5.18 | 5.18 |
| 495.32 | 4.13 | 4.13 |
| 502.33 | 6.27 | 6.27 |
| 529.43 | 6.20 | 6.20 |
| 544.51 | 7.27 | 7.27 |
| 561.51 | 6.51 | 6.51 |
| 432.88 | 3.88 | 3.88 |
| 432.35 | 6.65 | 6.65 |
| 495.32 | 4.13 | 4.13 |
| 461.88 | 3.73 | 3.73 |
| 481.36 | 4.74 | 4.74 |
| 479.87 | 4.22 | 4.22 |
| 517.46 | 6.12 | 6.12 |
| 435.31 | 4.10 | 4.10 |
| 578.52 | 7.99 | 7.99 |
| 501.37 | 5.42 | 5.42 |
| 492.91 | 3.79 | 3.79 |
| 502.36 | 4.06 | 4.06 |
| 491.38 | 4.71 | 4.71 |
| 512.78 | 5.25 | 5.25 |
| 601.49 | 6.77 | 6.77 |
| 531.47 | 5.48 | 5.48 |
| 575.77 | 4.82 | 4.82 |
| 593.46 | 5.30 | 5.30 |
| 511.78 | 4.65 | 4.65 |
| 561.51 | 6.51 | 6.51 |
| 457.91 | 3.90 | 3.90 |
| 518.47 | 5.68 | 5.68 |
| 529.43 | 5.85 | 5.85 |
| 491.42 | 5.57 | 5.57 |
| 553.82 | 4.42 | 4.42 |
| 501.37 | 5.12 | 5.12 |
| 463.37 | 4.83 | 4.83 |
| 493.37 | 5.07 | 5.07 |
| 516.39 | 4.40 | 4.40 |
| 529.43 | 5.85 | 5.85 |
| 515.40 | 5.46 | 5.46 |
| 461.31 | 4.72 | 4.72 |
| 540.77 | 4.84 | 4.84 |
| 549.81 | 3.85 | 3.85 |
| 527.43 | 4.12 | 4.12 |
| 584.10 | 7.79 | 7.79 |
| 477.39 | 5.22 | 5.22 |
| 501.37 | 5.47 | 5.47 |
| 583.43 | 5.34 | 5.34 |
| 537.82 | 5.18 | 5.18 |
| 543.86 | 8.04 | 8.04 |
| 591.54 | 6.09 | 6.09 |
| 479.36 | 4.07 | 4.07 |
| 478.33 | 4.25 | 4.25 |
| 550.79 | 4.43 | 4.43 |
| 503.43 | 5.71 | 5.71 |
| 567.43 | 5.18 | 5.18 |
| 576.83 | 5.34 | 5.34 |
| 505.40 | 4.75 | 4.75 |
| 477.33 | 3.99 | 3.99 |
| 574.85 | 5.66 | 5.66 |
| 503.43 | 5.57 | 5.57 |
| 530.48 | 6.88 | 6.88 |
| 476.41 | 4.70 | 4.70 |
| 568.30 | 6.08 | 6.08 |
| 467.33 | 4.54 | 4.54 |
| 433.32 | 5.72 | 5.72 |
| 490.39 | 5.16 | 5.16 |
| 537.82 | 5.18 | 5.18 |
| 449.34 | 4.40 | 4.40 |
| 574.85 | 5.66 | 5.66 |
| 529.38 | 5.20 | 5.20 |
| 589.50 | 5.47 | 5.47 |
| 556.45 | 4.70 | 4.70 |
| 490.42 | 5.79 | 5.79 |
| 463.76 | 4.88 | 4.88 |
| 509.37 | 4.31 | 4.31 |
| 476.39 | 5.79 | 5.79 |
| 545.50 | 5.47 | 5.47 |
| 539.83 | 5.43 | 5.43 |
| 590.91 | 3.96 | 3.96 |
| 585.50 | 3.85 | 3.85 |
| 532.45 | 5.56 | 5.56 |
| 521.80 | 3.93 | 3.93 |
| 434.32 | 5.64 | 5.64 |
| 491.38 | 4.71 | 4.71 |
| 507.77 | 3.67 | 3.67 |
| 510.41 | 6.79 | 6.79 |
| 533.50 | 6.74 | 6.74 |
| 516.45 | 6.54 | 6.54 |
| 493.79 | 4.51 | 4.51 |
| 530.42 | 4.79 | 4.79 |
| 509.37 | 4.31 | 4.31 |
| 528.23 | 5.16 | 5.16 |
| 475.38 | 4.93 | 4.93 |
| 521.40 | 4.33 | 4.33 |
| 549.46 | 5.11 | 5.11 |
| 547.53 | 7.13 | 7.13 |
| 446.38 | 7.04 | 7.04 |
| 535.43 | 4.53 | 4.53 |
| 556.29 | 5.94 | 5.94 |
| 545.51 | 6.90 | 6.90 |
| 575.40 | 5.89 | 5.89 |
| 462.38 | 4.31 | 4.31 |
| 577.42 | 8.41 | 8.41 |
| 509.41 | 5.52 | 5.52 |
| 595.53 | 6.95 | 6.95 |
| 520.39 | 4.51 | 4.51 |
| 477.39 | 5.18 | 5.18 |
| 515.40 | 5.81 | 5.81 |
| 538.39 | 6.37 | 6.37 |
| 564.45 | 4.32 | 4.32 |
| 501.37 | 5.12 | 5.12 |
| 477.35 | 4.31 | 4.31 |
| 524.36 | 6.33 | 6.33 |
| 505.45 | 5.81 | 5.81 |
| 586.85 | 3.69 | 3.69 |
| 560.44 | 3.84 | 3.84 |
| 533.46 | 5.73 | 5.73 |
| 550.82 | 4.28 | 4.28 |
| 507.42 | 4.80 | 4.80 |
| 496.32 | 4.74 | 4.74 |