Assay Report Card

Basic Information

ID: ALA3883067

Type: Binding

Description: Inhibition of recombinant human N-terminal GST His6-tagged thrombin cleavage site-fused EGFR (H672 to A1210 residues) expressed in baculovirus using poly-EY as substrate after 210 mins by luciferase coupled chemiluminescence assay

Organism: Homo sapiens

Activity Charts

Bioactivity

Activity Types for Assay ALA3883067

IC50

Total(327)

Compound Summary

Parent Molecular Weight	ALogP	Polar Surface Area
491.39	5.79	5.79
504.42	4.62	4.62
513.55	3.31	3.31
463.37	4.71	4.71
538.81	4.09	4.09
513.40	3.73	3.73
473.37	4.16	4.16
432.88	3.88	3.88
564.45	4.32	4.32
576.27	8.54	8.54
479.36	3.76	3.76
508.76	3.70	3.70
492.36	4.50	4.50
516.45	6.19	6.19
555.48	4.90	4.90
491.38	4.70	4.70
509.37	4.31	4.31
581.50	6.49	6.49
545.50	5.87	5.87
478.93	4.80	4.80
557.23	5.36	5.36
502.37	4.01	4.01
505.40	4.75	4.75
506.39	6.51	6.51
531.48	6.35	6.35
510.41	6.79	6.79
570.85	3.76	3.76
493.37	5.07	5.07
521.36	3.77	3.77
428.92	4.05	4.05
544.51	6.92	6.92
489.40	5.18	5.18
502.36	3.56	3.56
530.48	6.53	6.53
554.27	5.68	5.68
515.40	5.81	5.81
502.40	5.07	5.07
493.79	4.51	4.51
549.41	4.25	4.25
553.49	6.40	6.40
520.39	4.56	4.56
516.45	6.32	6.32
462.28	6.55	6.55
567.45	7.08	7.08
602.48	5.71	5.71
589.50	5.30	5.30
573.42	5.02	5.02
449.34	4.40	4.40
495.97	3.48	3.48
544.51	6.92	6.92
601.49	7.11	7.11
433.34	5.16	5.16
589.48	6.76	6.76
570.27	4.93	4.93
483.78	5.05	5.05
515.40	5.81	5.81
467.33	4.54	4.54
428.92	4.05	4.05
536.81	4.75	4.75
447.37	5.55	5.55
519.43	5.34	5.34
509.37	4.31	4.31
563.88	5.05	5.05
487.35	5.08	5.08
494.35	3.98	3.98
509.35	5.36	5.36
450.87	4.02	4.02
522.78	4.36	4.36
530.48	6.88	6.88
543.43	6.11	6.11
493.79	4.51	4.51
473.37	4.16	4.16
545.51	6.74	6.74
499.93	3.44	3.44
493.39	4.41	4.41
545.50	5.47	5.47
538.24	4.62	4.62
477.39	5.18	5.18
463.37	4.83	4.83
463.32	3.93	3.93
559.54	7.13	7.13
553.82	4.42	4.42
491.42	5.57	5.57
447.37	5.55	5.55
473.37	4.16	4.16
539.46	6.01	6.01
510.41	6.79	6.79
492.36	3.25	3.25
526.42	5.36	5.36
419.43	0.37	0.37
577.51	6.87	6.87
475.38	4.93	4.93
493.42	4.84	4.84
449.34	4.45	4.45
567.47	5.93	5.93
523.42	3.78	3.78
495.38	5.32	5.32
491.42	5.57	5.57
478.33	4.60	4.60
501.41	5.18	5.18
404.30	5.87	5.87
459.38	5.41	5.41
531.44	5.49	5.49
519.47	6.20	6.20
463.37	4.71	4.71
495.38	5.32	5.32
558.76	4.95	4.95
577.86	4.04	4.04
476.91	4.56	4.56
580.54	8.24	8.24
493.39	4.41	4.41
530.46	5.85	5.85
518.43	5.56	5.56
511.78	4.65	4.65
561.86	4.81	4.81
575.90	4.73	4.73
507.82	4.82	4.82
553.82	4.42	4.42
496.32	4.74	4.74
495.56	3.02	3.02
554.27	5.69	5.69
527.43	4.12	4.12
529.42	5.24	5.24
420.30	5.25	5.25
520.47	6.06	6.06
575.89	5.20	5.20
519.43	4.95	4.95
553.82	4.42	4.42
533.50	6.59	6.59
477.39	5.18	5.18
390.27	5.48	5.48
475.38	4.93	4.93
516.84	8.14	8.14
436.30	4.83	4.83
522.78	4.36	4.36
505.45	5.96	5.96
593.39	6.03	6.03
530.48	6.53	6.53
516.45	6.49	6.49
489.40	5.32	5.32
491.42	5.57	5.57
510.35	4.64	4.64
475.38	4.93	4.93
533.46	5.88	5.88
492.76	4.73	4.73
503.43	5.73	5.73
473.36	4.40	4.40
519.47	6.35	6.35
501.37	5.42	5.42
480.33	3.64	3.64
550.79	4.27	4.27
575.47	5.16	5.16
524.36	6.33	6.33
487.39	4.79	4.79
473.37	4.16	4.16
571.26	5.26	5.26
512.40	5.37	5.37
524.78	3.75	3.75
503.35	4.49	4.49
463.37	4.79	4.79
449.84	4.06	4.06
490.44	5.09	5.09
477.39	5.18	5.18
535.43	4.72	4.72
513.34	5.92	5.92
502.43	5.71	5.71
560.75	5.52	5.52
491.42	5.57	5.57
539.83	5.43	5.43
463.35	5.22	5.22
450.72	4.97	4.97
528.39	4.17	4.17
520.39	4.56	4.56
570.48	5.09	5.09
587.89	6.19	6.19
463.37	4.79	4.79
495.32	4.13	4.13
477.39	5.18	5.18
530.42	4.21	4.21
533.46	5.73	5.73
532.45	5.56	5.56
491.38	4.17	4.17
568.44	6.20	6.20
585.86	3.26	3.26
508.37	6.63	6.63
474.95	3.76	3.76
517.44	5.13	5.13
483.78	5.05	5.05
503.43	5.73	5.73
508.76	3.70	3.70
583.47	5.55	5.55
506.37	4.17	4.17
493.79	4.51	4.51
488.40	5.37	5.37
516.45	6.19	6.19
494.34	6.32	6.32
492.91	3.79	3.79
475.38	4.95	4.95
540.77	4.84	4.84
491.42	5.57	5.57
538.85	5.07	5.07
558.42	5.21	5.21
506.37	4.17	4.17
519.47	6.20	6.20
579.79	8.49	8.49
432.88	3.88	3.88
502.43	6.15	6.15
512.35	2.52	2.52
450.32	5.22	5.22
535.47	5.32	5.32
550.45	7.62	7.62
532.47	4.86	4.86
545.51	6.74	6.74
449.34	4.40	4.40
432.88	3.88	3.88
487.35	5.08	5.08
404.30	6.01	6.01
559.52	5.86	5.86
477.39	5.18	5.18
495.32	4.13	4.13
502.33	6.27	6.27
529.43	6.20	6.20
544.51	7.27	7.27
561.51	6.51	6.51
432.88	3.88	3.88
432.35	6.65	6.65
495.32	4.13	4.13
461.88	3.73	3.73
481.36	4.74	4.74
479.87	4.22	4.22
517.46	6.12	6.12
435.31	4.10	4.10
578.52	7.99	7.99
501.37	5.42	5.42
492.91	3.79	3.79
502.36	4.06	4.06
491.38	4.71	4.71
512.78	5.25	5.25
601.49	6.77	6.77
531.47	5.48	5.48
575.77	4.82	4.82
593.46	5.30	5.30
511.78	4.65	4.65
561.51	6.51	6.51
457.91	3.90	3.90
518.47	5.68	5.68
529.43	5.85	5.85
491.42	5.57	5.57
553.82	4.42	4.42
463.37	4.83	4.83
493.37	5.07	5.07
516.39	4.40	4.40
529.43	5.85	5.85
461.31	4.72	4.72
540.77	4.84	4.84
549.81	3.85	3.85
527.43	4.12	4.12
584.10	7.79	7.79
477.39	5.22	5.22
583.43	5.34	5.34
537.82	5.18	5.18
543.86	8.04	8.04
591.54	6.09	6.09
479.36	4.07	4.07
478.33	4.25	4.25
550.79	4.43	4.43
503.43	5.71	5.71
567.43	5.18	5.18
576.83	5.34	5.34
505.40	4.75	4.75
477.33	3.99	3.99
574.85	5.66	5.66
503.43	5.57	5.57
530.48	6.88	6.88
476.41	4.70	4.70
568.30	6.08	6.08
467.33	4.54	4.54
433.32	5.72	5.72
490.39	5.16	5.16
537.82	5.18	5.18
449.34	4.40	4.40
574.85	5.66	5.66
529.38	5.20	5.20
589.50	5.47	5.47
556.45	4.70	4.70
463.76	4.88	4.88
509.37	4.31	4.31
476.39	5.79	5.79
539.83	5.43	5.43
590.91	3.96	3.96
585.50	3.85	3.85
521.80	3.93	3.93
491.38	4.71	4.71
507.77	3.67	3.67
510.41	6.79	6.79
533.50	6.74	6.74
516.45	6.54	6.54
493.79	4.51	4.51
530.42	4.79	4.79
509.37	4.31	4.31
528.23	5.16	5.16
475.38	4.93	4.93
521.40	4.33	4.33
549.46	5.11	5.11
547.53	7.13	7.13
446.38	7.04	7.04
535.43	4.53	4.53
556.29	5.94	5.94
545.51	6.90	6.90
575.40	5.89	5.89
462.38	4.31	4.31
577.42	8.41	8.41
509.41	5.52	5.52
595.53	6.95	6.95
520.39	4.51	4.51
477.39	5.18	5.18
538.39	6.37	6.37
564.45	4.32	4.32
477.35	4.31	4.31
524.36	6.33	6.33
505.45	5.81	5.81
586.85	3.69	3.69
560.44	3.84	3.84
533.46	5.73	5.73
550.82	4.28	4.28
507.42	4.80	4.80
496.32	4.74	4.74