Basic Information
ID: ALA3883068
Type: Binding
Description: Inhibition of recombinant human N-terminal GST His6-tagged thrombin cleavage site-fused ErbB2 kinase domain (Q679 to V1255 residues) expressed in baculovirus infected insect Sf9 cells using biotinylated poly-EY as substrate after 60 mins by alphascreen assay
Format: BAO_0000219
Organism: Homo sapiens
Cell type: Sf9
Target: Receptor protein-tyrosine kinase erbB-2(ALA1824)
Document: ALA3882729
Inhibition of recombinant human N-terminal GST His6-tagged thrombin cleavage site-fused ErbB2 kinase domain (Q679 to V1255 residues) expressed in baculovirus infected insect Sf9 cells using biotinylated poly-EY as substrate after 60 mins by alphascreen assay: 38
Activity Charts
Bioactivity
Activity Types for Assay ALA3883068
IC50
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 491.39 | 5.79 | 5.79 |
| 513.40 | 3.73 | 3.73 |
| 492.36 | 4.50 | 4.50 |
| 509.37 | 4.31 | 4.31 |
| 557.23 | 5.36 | 5.36 |
| 502.37 | 4.01 | 4.01 |
| 493.37 | 5.07 | 5.07 |
| 502.36 | 3.56 | 3.56 |
| 530.48 | 6.53 | 6.53 |
| 520.39 | 4.56 | 4.56 |
| 495.97 | 3.48 | 3.48 |
| 570.27 | 4.93 | 4.93 |
| 483.78 | 5.05 | 5.05 |
| 536.81 | 4.75 | 4.75 |
| 509.37 | 4.31 | 4.31 |
| 509.35 | 5.36 | 5.36 |
| 522.78 | 4.36 | 4.36 |
| 499.93 | 3.44 | 3.44 |
| 553.82 | 4.42 | 4.42 |
| 491.42 | 5.57 | 5.57 |
| 473.37 | 4.16 | 4.16 |
| 492.36 | 3.25 | 3.25 |
| 475.38 | 4.93 | 4.93 |
| 493.42 | 4.84 | 4.84 |
| 449.34 | 4.45 | 4.45 |
| 491.42 | 5.57 | 5.57 |
| 478.33 | 4.60 | 4.60 |
| 459.38 | 5.41 | 5.41 |
| 531.44 | 5.49 | 5.49 |
| 558.76 | 4.95 | 4.95 |
| 476.91 | 4.56 | 4.56 |
| 530.46 | 5.85 | 5.85 |
| 518.43 | 5.56 | 5.56 |
| 575.90 | 4.73 | 4.73 |
| 553.82 | 4.42 | 4.42 |
| 496.32 | 4.74 | 4.74 |
| 554.27 | 5.69 | 5.69 |
| 527.43 | 4.12 | 4.12 |
| 553.82 | 4.42 | 4.42 |
| 390.27 | 5.48 | 5.48 |
| 475.38 | 4.93 | 4.93 |
| 522.78 | 4.36 | 4.36 |
| 530.48 | 6.53 | 6.53 |
| 510.35 | 4.64 | 4.64 |
| 475.38 | 4.93 | 4.93 |
| 492.76 | 4.73 | 4.73 |
| 571.26 | 5.26 | 5.26 |
| 463.37 | 4.79 | 4.79 |
| 477.39 | 5.18 | 5.18 |
| 502.43 | 5.71 | 5.71 |
| 520.39 | 4.56 | 4.56 |
| 570.48 | 5.09 | 5.09 |
| 463.37 | 4.79 | 4.79 |
| 530.42 | 4.21 | 4.21 |
| 491.38 | 4.17 | 4.17 |
| 483.78 | 5.05 | 5.05 |
| 506.37 | 4.17 | 4.17 |
| 493.79 | 4.51 | 4.51 |
| 488.40 | 5.37 | 5.37 |
| 516.45 | 6.19 | 6.19 |
| 492.91 | 3.79 | 3.79 |
| 540.77 | 4.84 | 4.84 |
| 558.42 | 5.21 | 5.21 |
| 506.37 | 4.17 | 4.17 |
| 512.35 | 2.52 | 2.52 |
| 529.43 | 6.20 | 6.20 |
| 461.88 | 3.73 | 3.73 |
| 479.87 | 4.22 | 4.22 |
| 492.91 | 3.79 | 3.79 |
| 502.36 | 4.06 | 4.06 |
| 491.38 | 4.71 | 4.71 |
| 512.78 | 5.25 | 5.25 |
| 531.47 | 5.48 | 5.48 |
| 457.91 | 3.90 | 3.90 |
| 518.47 | 5.68 | 5.68 |
| 529.43 | 5.85 | 5.85 |
| 553.82 | 4.42 | 4.42 |
| 463.37 | 4.83 | 4.83 |
| 493.37 | 5.07 | 5.07 |
| 516.39 | 4.40 | 4.40 |
| 529.43 | 5.85 | 5.85 |
| 540.77 | 4.84 | 4.84 |
| 527.43 | 4.12 | 4.12 |
| 537.82 | 5.18 | 5.18 |
| 478.33 | 4.25 | 4.25 |
| 550.79 | 4.43 | 4.43 |
| 568.30 | 6.08 | 6.08 |
| 490.39 | 5.16 | 5.16 |
| 537.82 | 5.18 | 5.18 |
| 574.85 | 5.66 | 5.66 |
| 556.45 | 4.70 | 4.70 |
| 509.37 | 4.31 | 4.31 |
| 491.38 | 4.71 | 4.71 |
| 516.45 | 6.54 | 6.54 |
| 509.37 | 4.31 | 4.31 |
| 475.38 | 4.93 | 4.93 |
| 520.39 | 4.51 | 4.51 |
| 477.39 | 5.18 | 5.18 |
| 550.82 | 4.28 | 4.28 |
| 496.32 | 4.74 | 4.74 |