Assay Report Card

Basic Information

ID: ALA3883076

Type: Binding

Description: Antagonist activity at C-terminal halo-tag fused human ferroportin expressed in MDCK cells assessed as inhibition of hepcidin-induced ferroportin internalization after overnight incubation by Draq5 staining-based fluorescence assay

Organism: Homo sapiens

Cell type: MDCK

Activity Charts

Bioactivity

Activity Types for Assay ALA3883076

IC50

Total(250)

Compound Summary

Parent Molecular Weight	ALogP	Polar Surface Area
329.34	2.94	2.94
284.34	3.04	3.04
296.35	3.32	3.32
350.32	4.03	4.03
312.35	3.02	3.02
282.32	3.02	3.02
369.26	3.86	3.86
343.41	2.93	2.93
313.38	2.93	2.93
299.36	2.62	2.62
316.77	3.67	3.67
300.31	3.16	3.16
397.33	3.96	3.96
298.37	3.34	3.34
298.37	3.34	3.34
314.37	3.04	3.04
329.38	2.63	2.63
359.36	2.95	2.95
314.37	3.04	3.04
373.41	3.07	3.07
422.28	3.83	3.83
298.37	3.34	3.34
332.81	4.00	4.00
368.34	3.93	3.93
302.33	3.17	3.17
389.86	3.73	3.73
365.46	4.01	4.01
312.35	3.02	3.02
318.79	3.69	3.69
329.36	2.72	2.72
332.81	4.00	4.00
377.85	3.97	3.97
316.77	3.67	3.67
363.24	3.80	3.80
485.59	2.49	2.49
367.43	2.59	2.59
235.27	0.99	0.99
443.91	3.58	3.58
437.57	2.70	2.70
313.38	2.93	2.93
371.22	4.48	4.48
352.75	3.95	3.95
367.26	4.65	4.65
441.53	2.47	2.47
370.48	3.01	3.01
309.35	2.91	2.91
401.80	4.29	4.29
378.33	3.32	3.32
457.53	2.36	2.36
347.33	3.08	3.08
366.80	3.84	3.84
314.37	3.04	3.04
369.45	2.87	2.87
366.32	3.91	3.91
320.32	3.31	3.31
286.32	1.83	1.83
367.43	2.85	2.85
352.34	4.05	4.05
429.89	3.14	3.14
385.42	3.27	3.27
300.34	2.97	2.97
387.68	5.00	5.00
341.78	3.54	3.54
350.32	4.03	4.03
456.50	2.54	2.54
291.36	2.49	2.49
355.42	3.07	3.07
387.85	3.37	3.37
387.44	3.12	3.12
318.79	3.69	3.69
303.32	2.57	2.57
436.54	3.23	3.23
316.36	3.48	3.48
298.37	3.34	3.34
368.34	3.93	3.93
327.41	3.10	3.10
390.46	4.61	4.61
326.38	3.07	3.07
353.32	3.45	3.45
325.39	2.93	2.93
369.45	3.63	3.63
296.35	3.04	3.04
415.90	3.63	3.63
353.23	4.34	4.34
369.32	3.33	3.33
395.44	2.49	2.49
395.36	3.54	3.54
296.35	3.32	3.32
351.21	4.32	4.32
387.89	4.52	4.52
339.42	3.23	3.23
369.45	3.10	3.10
335.39	3.58	3.58
370.33	4.19	4.19
302.33	3.17	3.17
355.46	3.88	3.88
298.37	3.34	3.34
344.37	2.46	2.46
336.78	3.83	3.83
353.45	3.86	3.86
400.48	3.00	3.00
312.35	3.02	3.02
299.36	2.74	2.74
396.47	2.31	2.31
354.76	3.97	3.97
326.33	2.71	2.71
436.54	3.23	3.23
249.29	1.56	1.56
325.35	2.11	2.11
429.89	2.88	2.88
344.37	2.46	2.46
318.79	3.69	3.69
328.39	3.43	3.43
312.39	3.60	3.60
384.77	4.69	4.69
314.37	3.04	3.04
443.91	3.27	3.27
343.38	3.07	3.07
310.38	3.63	3.63
312.35	3.02	3.02
394.86	3.07	3.07
394.33	3.20	3.20
318.79	3.69	3.69
338.31	3.45	3.45
355.42	2.93	2.93
394.38	3.34	3.34
311.37	2.91	2.91
421.32	4.47	4.47
340.36	2.80	2.80
365.36	3.29	3.29
296.35	3.32	3.32
298.37	3.34	3.34
249.29	1.34	1.34
343.41	2.93	2.93
328.33	2.44	2.44
397.38	3.65	3.65
367.26	4.65	4.65
263.32	1.90	1.90
320.32	3.31	3.31
299.36	3.00	3.00
429.89	3.19	3.19
314.34	3.46	3.46
300.31	3.16	3.16
405.86	2.43	2.43
341.39	2.40	2.40
285.33	2.43	2.43
385.45	2.94	2.94
350.80	4.14	4.14
300.31	3.16	3.16
342.38	2.82	2.82
331.78	3.25	3.25
327.37	2.13	2.13
380.35	4.04	4.04
368.34	3.93	3.93
348.39	3.20	3.20
384.77	4.69	4.69
352.34	4.05	4.05
353.40	2.72	2.72
410.50	2.76	2.76
318.79	3.69	3.69
314.37	3.04	3.04
368.31	4.17	4.17
299.36	2.74	2.74
336.78	3.83	3.83
283.31	2.41	2.41
387.68	5.00	5.00
368.46	2.99	2.99
347.83	3.58	3.58
318.79	3.69	3.69
417.87	3.05	3.05
357.41	3.37	3.37
377.83	3.72	3.72
381.38	3.95	3.95
340.36	2.80	2.80
351.43	3.62	3.62
318.79	3.69	3.69
409.39	4.01	4.01
326.42	4.16	4.16
342.38	2.82	2.82
437.32	4.35	4.35
382.49	3.01	3.01
384.77	4.69	4.69
353.23	4.34	4.34
437.44	4.65	4.65
310.34	2.30	2.30
360.82	4.07	4.07
314.37	3.04	3.04
312.35	3.02	3.02
352.34	4.05	4.05
341.39	2.99	2.99
463.36	4.56	4.56
277.35	2.29	2.29
319.77	3.08	3.08
400.89	4.99	4.99
343.38	3.07	3.07
336.78	3.83	3.83
342.38	2.82	2.82
315.35	2.44	2.44
296.35	3.32	3.32
303.32	2.57	2.57
352.34	4.05	4.05
433.87	1.75	1.75
369.20	4.46	4.46
298.37	3.34	3.34
317.35	2.76	2.76
316.77	3.67	3.67
313.38	3.08	3.08
296.35	3.32	3.32
350.32	4.03	4.03
380.35	4.04	4.04
382.27	4.62	4.62
383.26	4.35	4.35
309.35	2.91	2.91
377.83	3.72	3.72
369.45	2.96	2.96
300.31	3.16	3.16
361.22	3.78	3.78
350.32	4.03	4.03
361.37	3.20	3.20
353.23	4.34	4.34
325.39	3.08	3.08
307.33	2.89	2.89
316.77	3.67	3.67
393.39	3.95	3.95
353.33	3.45	3.45
368.46	2.99	2.99
339.38	2.38	2.38
327.41	3.23	3.23
355.42	2.93	2.93
325.39	3.08	3.08
444.94	3.41	3.41
298.37	3.34	3.34
299.36	2.74	2.74
428.90	4.77	4.77
332.81	4.00	4.00
353.32	3.45	3.45
367.35	3.64	3.64
369.32	3.33	3.33
443.55	2.72	2.72
401.88	3.51	3.51
285.33	2.43	2.43
385.42	3.27	3.27
311.37	3.06	3.06
339.38	2.38	2.38
409.39	3.82	3.82
297.34	2.60	2.60
395.31	5.27	5.27
300.34	2.74	2.74
325.35	2.11	2.11
312.39	3.65	3.65