Basic Information
ID: ALA3883077
Type: Binding
Description: Inhibition of COX2 in C57BL/6 mouse peritoneal macrophages assessed as reduction in PGE2 formation pre-incubated for 2 hrs before LPS stimulation for 16 hrs followed by arachidonic acid addition and measured after 10 mins in presence of 500 uM aspirin by radio-immuno assay or enzyme-immunoassay
Organism: Mus musculus
Strain: C57BL/6
Activity Charts
Bioactivity
Activity Types for Assay ALA3883077
IC50
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 384.50 | 4.29 | 4.29 |
| 378.40 | 3.61 | 3.61 |
| 360.41 | 3.48 | 3.48 |
| 376.86 | 3.99 | 3.99 |
| 376.86 | 3.99 | 3.99 |
| 410.41 | 4.36 | 4.36 |
| 384.45 | 3.54 | 3.54 |
| 378.40 | 3.61 | 3.61 |
| 384.50 | 4.46 | 4.46 |
| 378.40 | 3.61 | 3.61 |
| 411.31 | 4.64 | 4.64 |
| 384.50 | 4.46 | 4.46 |
| 386.47 | 3.39 | 3.39 |
| 372.44 | 3.34 | 3.34 |
| 362.40 | 3.95 | 3.95 |
| 360.86 | 4.32 | 4.32 |
| 361.39 | 2.72 | 2.72 |
| 397.37 | 3.00 | 3.00 |
| 379.38 | 2.86 | 2.86 |
| 361.39 | 2.72 | 2.72 |
| 378.40 | 3.61 | 3.61 |
| 379.38 | 2.86 | 2.86 |
| 377.85 | 3.23 | 3.23 |
| 361.39 | 2.72 | 2.72 |
| 360.41 | 3.48 | 3.48 |
| 410.54 | 4.99 | 4.99 |
| 384.50 | 4.42 | 4.42 |
| 438.47 | 5.14 | 5.14 |
| 379.38 | 2.86 | 2.86 |
| 348.45 | 3.40 | 3.40 |
| 397.37 | 3.00 | 3.00 |
| 332.38 | 2.93 | 2.93 |
| 372.44 | 3.34 | 3.34 |
| 347.40 | 1.31 | 1.31 |
| 333.37 | 2.17 | 2.17 |
| 384.45 | 3.54 | 3.54 |
| 398.52 | 4.68 | 4.68 |
| 396.39 | 3.75 | 3.75 |
| 378.40 | 3.61 | 3.61 |
| 394.85 | 4.13 | 4.13 |
| 396.39 | 3.75 | 3.75 |
| 394.85 | 4.13 | 4.13 |
| 360.41 | 3.48 | 3.48 |
| 368.45 | 3.87 | 3.87 |
| 382.48 | 4.18 | 4.18 |
| 356.44 | 3.73 | 3.73 |
| 394.85 | 4.13 | 4.13 |
| 396.39 | 3.75 | 3.75 |
| 402.44 | 3.25 | 3.25 |
| 357.43 | 2.92 | 2.92 |
| 394.85 | 4.13 | 4.13 |
| 395.84 | 3.37 | 3.37 |
| 358.42 | 3.04 | 3.04 |
| 393.41 | 3.17 | 3.17 |
| 422.91 | 4.91 | 4.91 |
| 348.45 | 3.40 | 3.40 |
| 376.86 | 3.99 | 3.99 |
| 397.37 | 3.00 | 3.00 |
| 410.92 | 4.93 | 4.93 |
| 422.30 | 3.34 | 3.34 |
| 444.86 | 5.01 | 5.01 |
| 396.39 | 3.75 | 3.75 |
| 385.44 | 2.78 | 2.78 |
| 412.29 | 3.89 | 3.89 |
| 455.76 | 4.75 | 4.75 |
| 403.53 | 3.69 | 3.69 |
| 403.46 | 2.60 | 2.60 |
| 412.29 | 3.89 | 3.89 |
| 374.43 | 3.78 | 3.78 |
| 403.46 | 2.60 | 2.60 |
| 344.41 | 3.81 | 3.81 |
| 405.90 | 3.88 | 3.88 |
| 379.38 | 2.86 | 2.86 |
| 391.88 | 3.49 | 3.49 |
| 344.41 | 3.81 | 3.81 |
| 387.41 | 3.24 | 3.24 |
| 379.38 | 2.86 | 2.86 |
| 395.84 | 3.37 | 3.37 |
| 358.42 | 3.04 | 3.04 |
| 411.31 | 4.64 | 4.64 |
| 396.39 | 3.75 | 3.75 |
| 379.38 | 2.86 | 2.86 |
| 360.39 | 2.74 | 2.74 |
| 399.47 | 3.17 | 3.17 |
| 457.29 | 4.38 | 4.38 |
| 363.46 | 3.03 | 3.03 |
| 418.49 | 4.26 | 4.26 |
| 412.84 | 4.27 | 4.27 |
| 378.40 | 3.61 | 3.61 |
| 457.29 | 4.38 | 4.38 |
| 310.42 | 4.65 | 4.65 |
| 390.43 | 3.48 | 3.48 |
| 418.90 | 3.76 | 3.76 |
| 421.31 | 4.10 | 4.10 |
| 362.47 | 3.71 | 3.71 |
| 412.84 | 4.27 | 4.27 |
| 378.40 | 3.61 | 3.61 |
| 412.51 | 4.32 | 4.32 |
| 377.85 | 3.23 | 3.23 |
| 357.43 | 3.12 | 3.12 |
| 376.46 | 3.21 | 3.21 |
| 425.29 | 5.70 | 5.70 |
| 392.42 | 3.92 | 3.92 |
| 344.41 | 3.81 | 3.81 |
| 439.30 | 4.24 | 4.24 |
| 373.43 | 2.59 | 2.59 |
| 344.86 | 5.31 | 5.31 |
| 418.51 | 5.00 | 5.00 |
| 359.40 | 2.29 | 2.29 |
| 362.40 | 3.95 | 3.95 |
| 387.46 | 2.98 | 2.98 |
| 361.39 | 2.72 | 2.72 |
| 413.83 | 3.51 | 3.51 |
| 428.40 | 4.49 | 4.49 |
| 376.50 | 4.10 | 4.10 |
| 356.44 | 3.64 | 3.64 |
| 398.52 | 4.63 | 4.63 |
| 360.41 | 3.48 | 3.48 |
| 396.39 | 3.75 | 3.75 |
| 374.43 | 3.78 | 3.78 |
| 396.39 | 3.75 | 3.75 |
| 412.29 | 3.89 | 3.89 |
| 395.84 | 3.37 | 3.37 |
| 404.43 | 4.15 | 4.15 |