Basic Information
ID: ALA3885742
Type: Binding
Description: Recombinant Hsp90 [His-Tev-huHsp90-alpha (9-236)] was immobilized on a Biacore CM5 chip at 25 degrees C and a flow rate of 30 uL/min using amine coupling at pH 4.50 according to Biacore standard protocol. Hsp90 was applied at a concentration of 20 ug/mL with 50uM 17-DMAG.Data sets were processed and analyzed using the software Biacore 4000 Evaluation. Solvent corrected and double-referenced association and dissociation phase data were fitted to a simple 1:1 interaction model with mass transport limitations
Organism: Homo sapiens
Activity Charts
Bioactivity
Activity Types for Assay ALA3885742
k_off
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 296.33 | 3.47 | 3.47 |
| 387.82 | 3.57 | 3.57 |
| 512.38 | 3.28 | 3.28 |
| 457.91 | 3.66 | 3.66 |
| 388.81 | 3.83 | 3.83 |
| 405.89 | 4.78 | 4.78 |
| 385.47 | 4.44 | 4.44 |
| 364.41 | 3.25 | 3.25 |
| 469.59 | 4.20 | 4.20 |
| 484.47 | 3.42 | 3.42 |
| 410.15 | 2.24 | 2.24 |
| 470.53 | 3.81 | 3.81 |
| 454.57 | 5.43 | 5.43 |
| 287.25 | 1.78 | 1.78 |
| 371.44 | 4.44 | 4.44 |
| 412.47 | 3.80 | 3.80 |
| 322.20 | 3.38 | 3.38 |
| 366.15 | 2.54 | 2.54 |
| 396.45 | 2.53 | 2.53 |
| 460.49 | 3.23 | 3.23 |
| 385.47 | 4.75 | 4.75 |
| 410.47 | 2.83 | 2.83 |
| 465.55 | 2.76 | 2.76 |
| 455.56 | 3.85 | 3.85 |
| 408.46 | 2.97 | 2.97 |
| 414.51 | 4.51 | 4.51 |
| 430.46 | 3.22 | 3.22 |
| 465.55 | 3.25 | 3.25 |
| 444.49 | 3.53 | 3.53 |
| 436.49 | 3.28 | 3.28 |
| 386.38 | 2.26 | 2.26 |
| 448.61 | 5.33 | 5.33 |
| 444.49 | 3.53 | 3.53 |
| 424.46 | 2.20 | 2.20 |
| 366.42 | 4.71 | 4.71 |
| 479.54 | 2.24 | 2.24 |
| 460.49 | 3.23 | 3.23 |
| 304.35 | 2.68 | 2.68 |
| 320.35 | 2.38 | 2.38 |
| 331.26 | 1.48 | 1.48 |
| 334.38 | 2.69 | 2.69 |
| 406.53 | 4.31 | 4.31 |
| 306.32 | 2.07 | 2.07 |
| 456.55 | 4.28 | 4.28 |
| 391.40 | 3.56 | 3.56 |
| 408.50 | 3.90 | 3.90 |
| 424.39 | 2.64 | 2.64 |
| 422.44 | 1.81 | 1.81 |
| 473.37 | 4.10 | 4.10 |
| 400.41 | 2.65 | 2.65 |
| 508.54 | 3.68 | 3.68 |
| 507.55 | 4.28 | 4.28 |
| 465.55 | 3.11 | 3.11 |
| 415.50 | 2.93 | 2.93 |
| 253.26 | 3.42 | 3.42 |
| 465.51 | 1.85 | 1.85 |
| 415.45 | 4.17 | 4.17 |
| 419.91 | 5.09 | 5.09 |
| 312.34 | 4.16 | 4.16 |
| 449.51 | 2.62 | 2.62 |
| 493.56 | 2.63 | 2.63 |
| 383.25 | 3.44 | 3.44 |
| 396.45 | 3.53 | 3.53 |
| 290.33 | 2.37 | 2.37 |
| 306.33 | 2.07 | 2.07 |
| 391.86 | 4.78 | 4.78 |
| 348.41 | 3.08 | 3.08 |
| 422.44 | 1.81 | 1.81 |