Basic Information
ID: ALA3885754
Type: Binding
Description: Recombinant Hsp90 [His-Tev-huHsp90-alpha (9-236)] was immobilized on a Biacore CM5 chip at 25 degrees C and a flow rate of 30 uL/min using amine coupling at pH 4.50 according to Biacore standard protocol. Hsp90 was applied at a concentration of 20 ug/mL with 50uM 17-DMAG.Data sets were processed and analyzed using the software Biacore 4000 Evaluation. Solvent corrected and double-referenced association and dissociation phase data were fitted to a simple 1:1 interaction model with mass transport limitations
Organism: Homo sapiens
Activity Charts
Bioactivity
Activity Types for Assay ALA3885754
k_off
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 512.42 | 3.81 | 3.81 |
| 403.45 | 4.52 | 4.52 |
| 418.46 | 4.10 | 4.10 |
| 322.20 | 3.38 | 3.38 |
| 459.48 | 5.75 | 5.75 |
| 532.40 | 6.44 | 6.44 |
| 453.89 | 4.15 | 4.15 |
| 463.49 | 4.41 | 4.41 |
| 407.51 | 3.96 | 3.96 |
| 524.40 | 5.03 | 5.03 |
| 457.52 | 4.54 | 4.54 |
| 442.48 | 5.00 | 5.00 |
| 409.53 | 3.76 | 3.76 |
| 253.26 | 3.42 | 3.42 |
| 442.48 | 5.00 | 5.00 |
| 364.78 | 2.69 | 2.69 |
| 491.60 | 5.36 | 5.36 |