Basic Information
ID: ALA3885778
Type: Binding
Description: Recombinant Hsp90 [His-Tev-huHsp90-alpha (9-236)] was immobilized on a Biacore CM5 chip at 25 degrees C and a flow rate of 30 uL/min using amine coupling at pH 4.50 according to Biacore standard protocol. Hsp90 was applied at a concentration of 20 ug/mL with 50uM 17-DMAG.Data sets were processed and analyzed using the software Biacore 4000 Evaluation. Solvent corrected and double-referenced association and dissociation phase data were fitted to a simple 1:1 interaction model with mass transport limitations
Organism: Homo sapiens
Activity Charts
Bioactivity
Activity Types for Assay ALA3885778
k_off
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 283.29 | 1.95 | 1.95 |
| 287.25 | 1.78 | 1.78 |
| 366.15 | 2.54 | 2.54 |
| 430.46 | 3.22 | 3.22 |
| 444.49 | 3.53 | 3.53 |
| 403.44 | 4.12 | 4.12 |
| 436.49 | 3.28 | 3.28 |
| 386.38 | 2.26 | 2.26 |
| 303.71 | 2.29 | 2.29 |
| 297.31 | 2.20 | 2.20 |
| 407.51 | 4.91 | 4.91 |
| 424.46 | 2.20 | 2.20 |
| 328.80 | 4.68 | 4.68 |
| 424.39 | 2.64 | 2.64 |
| 422.44 | 1.81 | 1.81 |
| 400.41 | 2.65 | 2.65 |
| 382.42 | 2.51 | 2.51 |
| 352.39 | 3.88 | 3.88 |
| 382.42 | 2.43 | 2.43 |
| 396.16 | 3.69 | 3.69 |
| 438.89 | 2.32 | 2.32 |
| 422.44 | 1.81 | 1.81 |