Basic Information
ID: ALA3887056
Type: Binding
Description: Fluorescence Polarisation Assay: The fluorescence polarisation tests were carried out on microplates (384 wells). The Bcl-2 protein, at a final concentration of 2.50×10−8 M, is mixed with a fluorescent peptide (Fluorescein-REIGAQLRRMADDLNAQY), at a final concentration of 1.00×10−8 M in a buffer solution (Hepes 10 mM, NaCl 150 mM, Tween20 0.05%, pH 7.4), in the presence or in the absence of increasing concentrations of test compounds. After incubation for 2 hours, the fluorescence polarisation is measured.
Activity Charts
Bioactivity
Activity Types for Assay ALA3887056
IC50
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 755.32 | 7.61 | 7.61 |
| 803.88 | 8.47 | 8.47 |
| 726.28 | 7.60 | 7.60 |
| 773.89 | 7.45 | 7.45 |
| 789.93 | 7.34 | 7.34 |
| 712.29 | 8.45 | 8.45 |
| 705.26 | 6.46 | 6.46 |
| 772.91 | 7.33 | 7.33 |
| 782.38 | 8.21 | 8.21 |
| 763.34 | 8.25 | 8.25 |
| 742.85 | 7.25 | 7.25 |
| 726.28 | 7.60 | 7.60 |
| 690.84 | 6.27 | 6.27 |
| 768.36 | 8.61 | 8.61 |
| 770.37 | 8.86 | 8.86 |
| 728.82 | 6.94 | 6.94 |
| 777.92 | 7.68 | 7.68 |
| 724.86 | 6.85 | 6.85 |
| 753.35 | 7.75 | 7.75 |
| 764.88 | 6.69 | 6.69 |
| 755.32 | 7.61 | 7.61 |
| 781.36 | 7.66 | 7.66 |
| 772.32 | 8.36 | 8.36 |
| 757.29 | 6.81 | 6.81 |
| 777.92 | 7.34 | 7.34 |
| 775.91 | 7.30 | 7.30 |
| 704.77 | 6.55 | 6.55 |
| 696.85 | 7.08 | 7.08 |
| 738.86 | 7.10 | 7.10 |
| 800.80 | 7.83 | 7.83 |
| 750.90 | 6.97 | 6.97 |
| 749.74 | 8.69 | 8.69 |
| 798.78 | 8.33 | 8.33 |
| 738.88 | 7.24 | 7.24 |
| 799.29 | 8.76 | 8.76 |
| 737.88 | 7.71 | 7.71 |
| 749.91 | 7.58 | 7.58 |
| 777.92 | 7.69 | 7.69 |
| 744.29 | 6.89 | 6.89 |
| 773.89 | 7.89 | 7.89 |
| 767.37 | 8.14 | 8.14 |
| 750.30 | 8.33 | 8.33 |
| 754.33 | 8.22 | 8.22 |
| 768.36 | 8.61 | 8.61 |
| 752.31 | 7.84 | 7.84 |
| 745.28 | 7.46 | 7.46 |
| 737.86 | 6.25 | 6.25 |
| 767.88 | 5.99 | 5.99 |
| 777.92 | 7.69 | 7.69 |
| 731.29 | 7.74 | 7.74 |
| 733.91 | 7.87 | 7.87 |
| 701.27 | 7.73 | 7.73 |
| 741.33 | 8.22 | 8.22 |
| 751.88 | 6.77 | 6.77 |
| 791.95 | 8.07 | 8.07 |
| 789.93 | 7.69 | 7.69 |
| 762.91 | 6.82 | 6.82 |
| 726.28 | 7.60 | 7.60 |
| 744.82 | 6.44 | 6.44 |
| 737.25 | 8.01 | 8.01 |
| 765.91 | 6.80 | 6.80 |
| 718.80 | 6.86 | 6.86 |
| 794.83 | 7.70 | 7.70 |
| 726.83 | 6.51 | 6.51 |
| 684.81 | 7.21 | 7.21 |
| 726.83 | 6.74 | 6.74 |
| 703.24 | 6.92 | 6.92 |
| 865.00 | 7.71 | 7.71 |
| 791.95 | 7.73 | 7.73 |
| 719.26 | 7.87 | 7.87 |
| 749.87 | 6.91 | 6.91 |
| 777.92 | 7.68 | 7.68 |
| 737.25 | 8.01 | 8.01 |
| 815.36 | 9.47 | 9.47 |
| 735.26 | 7.37 | 7.37 |
| 770.37 | 8.11 | 8.11 |
| 726.83 | 5.77 | 5.77 |
| 761.88 | 6.91 | 6.91 |
| 791.87 | 7.65 | 7.65 |
| 700.81 | 6.18 | 6.18 |
| 765.87 | 6.49 | 6.49 |
| 756.35 | 7.72 | 7.72 |
| 793.96 | 7.23 | 7.23 |
| 767.93 | 6.74 | 6.74 |
| 776.94 | 7.21 | 7.21 |
| 784.40 | 8.46 | 8.46 |
| 710.83 | 6.80 | 6.80 |
| 763.89 | 7.30 | 7.30 |
| 759.86 | 7.41 | 7.41 |
| 742.32 | 7.70 | 7.70 |
| 787.88 | 8.59 | 8.59 |
| 772.39 | 8.57 | 8.57 |
| 763.94 | 7.97 | 7.97 |
| 719.26 | 7.87 | 7.87 |
| 756.35 | 7.72 | 7.72 |
| 707.30 | 7.79 | 7.79 |
| 735.71 | 8.38 | 8.38 |
| 725.78 | 6.45 | 6.45 |
| 745.88 | 7.69 | 7.69 |
| 737.25 | 8.01 | 8.01 |
| 764.88 | 6.06 | 6.06 |
| 756.30 | 7.41 | 7.41 |
| 795.94 | 6.67 | 6.67 |
| 756.35 | 8.47 | 8.47 |
| 787.94 | 6.05 | 6.05 |
| 719.26 | 7.87 | 7.87 |
| 716.83 | 7.66 | 7.66 |
| 772.35 | 7.56 | 7.56 |
| 715.85 | 7.68 | 7.68 |
| 787.92 | 8.45 | 8.45 |
| 724.86 | 7.11 | 7.11 |
| 715.29 | 8.04 | 8.04 |
| 778.91 | 6.73 | 6.73 |
| 728.87 | 7.53 | 7.53 |
| 706.80 | 6.92 | 6.92 |