Basic Information
ID: ALA3887315
Type: Binding
Description: Inhibition Assay: Methods for assessing the selectively of ACAT1 inhibitors are known in the art and can be based upon any conventional assay including, but not limited to the determination of the half maximal (50%) inhibitory concentration (IC) of a substance (i.e., 50% IC, or IC50), the binding affinity of the inhibitor (i.e., Ki), and/or the half maximal effective concentration (EC50) of the inhibitor for ACAT1 as compared to ACAT2. See, e.g., Lada, et al. (2004) J. Lipid Res. 45:378-386 and U.S. Pat. No. 5,968,749. ACAT1 and ACAT2 proteins that can be employed in such assays are well-known in the art and set forth, e.g., in GENBANK Accession Nos. NP-000010 (human ACAT1) and NP-005882 (human ACAT2). See also U.S. Pat. No. 5,834,283.
Organism: Homo sapiens
Activity Charts
Bioactivity
Activity Types for Assay ALA3887315
IC50
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 309.45 | 6.04 | 6.04 |
| 295.43 | 5.65 | 5.65 |
| 487.64 | 2.89 | 2.89 |
| 487.64 | 2.89 | 2.89 |
| 469.74 | 8.65 | 8.65 |
| 502.74 | 4.06 | 4.06 |
| 441.62 | 6.93 | 6.93 |
| 680.93 | 9.19 | 9.19 |
| 457.61 | 6.64 | 6.64 |
| 375.52 | 5.88 | 5.88 |
| 375.56 | 7.09 | 7.09 |
| 610.80 | 7.24 | 7.24 |
| 389.54 | 6.27 | 6.27 |