Basic Information
ID: ALA3887397
Type: Functional
Description: Receptor Activity Assay: The disclosed compounds and compositions can be evaluated for their ability to act as a potentiator of metabotropic glutamate receptor activity, in particular mGluR4 activity, by any suitable known methodology known in the art. For example, Chinese Hamster Ovary (CHO) cells transfected with human mGluR4 or HEK cells co-transfected with rat mGluR4 and the G-protein regulated Inwardly Rectifying Potassium channel (GIRK) were plated in clear bottom assay plates for assay in a Hamamatsu FDSS Fluorometric Plate Reader. The cells were loaded with either a Ca2+-sensitive fluorescent dye or the thallium responsive dye and the plates were washed and placed into a suitable kinetic plate reader. For human mGluR4 assays, a fluorescence baseline was established for 3-5 seconds, the disclosed compounds were then added to the cells, and the response in cells was measured.
Cell type: HEK293
Activity Charts
Bioactivity
Activity Types for Assay ALA3887397
EC50
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 262.68 | 3.49 | 3.49 |
| 372.22 | 5.20 | 5.20 |
| 212.22 | 1.49 | 1.49 |
| 225.25 | 2.40 | 2.40 |
| 278.24 | 3.72 | 3.72 |
| 266.35 | 4.00 | 4.00 |
| 274.72 | 2.79 | 2.79 |
| 228.23 | 2.84 | 2.84 |
| 238.29 | 3.26 | 3.26 |
| 416.83 | 4.45 | 4.45 |
| 258.71 | 3.66 | 3.66 |
| 309.33 | 2.45 | 2.45 |
| 260.68 | 3.06 | 3.06 |
| 348.79 | 4.59 | 4.59 |
| 313.58 | 4.66 | 4.66 |
| 412.88 | 4.17 | 4.17 |
| 244.69 | 3.35 | 3.35 |
| 262.68 | 3.49 | 3.49 |
| 285.28 | 3.05 | 3.05 |
| 274.71 | 3.36 | 3.36 |
| 258.37 | 3.58 | 3.58 |
| 371.23 | 5.80 | 5.80 |
| 217.26 | 2.16 | 2.16 |
| 306.32 | 2.24 | 2.24 |
| 314.78 | 3.35 | 3.35 |
| 258.71 | 3.66 | 3.66 |
| 322.30 | 3.42 | 3.42 |
| 261.29 | 3.25 | 3.25 |
| 276.70 | 3.36 | 3.36 |
| 246.22 | 2.98 | 2.98 |
| 416.79 | 5.60 | 5.60 |
| 338.76 | 3.94 | 3.94 |
| 230.31 | 2.95 | 2.95 |
| 246.22 | 2.98 | 2.98 |
| 245.67 | 2.75 | 2.75 |
| 242.26 | 3.15 | 3.15 |
| 274.71 | 3.36 | 3.36 |
| 242.26 | 3.15 | 3.15 |
| 262.68 | 3.49 | 3.49 |
| 280.12 | 3.40 | 3.40 |
| 338.76 | 3.94 | 3.94 |
| 350.81 | 4.93 | 4.93 |
| 264.21 | 3.12 | 3.12 |
| 281.32 | 3.22 | 3.22 |
| 240.27 | 2.71 | 2.71 |
| 264.21 | 3.12 | 3.12 |
| 295.30 | 2.06 | 2.06 |
| 389.31 | 5.05 | 5.05 |
| 244.23 | 2.55 | 2.55 |
| 269.69 | 3.23 | 3.23 |
| 280.67 | 3.63 | 3.63 |
| 346.23 | 4.74 | 4.74 |
| 276.70 | 3.50 | 3.50 |
| 337.77 | 4.54 | 4.54 |
| 229.22 | 2.24 | 2.24 |
| 306.27 | 3.31 | 3.31 |
| 355.76 | 4.68 | 4.68 |
| 276.25 | 3.30 | 3.30 |
| 258.71 | 3.22 | 3.22 |
| 279.13 | 4.01 | 4.01 |
| 245.67 | 2.75 | 2.75 |
| 279.13 | 4.01 | 4.01 |
| 262.68 | 3.49 | 3.49 |
| 296.23 | 3.86 | 3.86 |
| 258.71 | 3.66 | 3.66 |
| 258.71 | 3.38 | 3.38 |
| 322.78 | 2.76 | 2.76 |
| 295.30 | 2.06 | 2.06 |
| 245.67 | 2.75 | 2.75 |
| 245.67 | 2.75 | 2.75 |
| 246.66 | 2.14 | 2.14 |
| 263.66 | 2.89 | 2.89 |
| 224.27 | 3.01 | 3.01 |
| 338.76 | 3.94 | 3.94 |
| 228.23 | 2.84 | 2.84 |
| 243.70 | 3.96 | 3.96 |
| 366.78 | 4.73 | 4.73 |
| 263.66 | 2.89 | 2.89 |
| 210.24 | 2.70 | 2.70 |
| 306.32 | 2.24 | 2.24 |
| 238.29 | 3.32 | 3.32 |
| 297.12 | 4.15 | 4.15 |
| 258.26 | 2.85 | 2.85 |
| 263.66 | 2.89 | 2.89 |
| 263.30 | 3.19 | 3.19 |
| 268.70 | 3.56 | 3.56 |
| 330.78 | 2.59 | 2.59 |
| 280.67 | 3.63 | 3.63 |
| 312.68 | 4.37 | 4.37 |
| 296.23 | 3.86 | 3.86 |