Basic Information
ID: ALA3887580
Type: Binding
Description: In vitro MMP-8 Assay: The synthetic octapeptide substrate, containing the collagenase-susceptible glycine-isoleucine peptide bond, was incubated (37° C.) with commercially-available chromatrographically-purified human neutrophil collagenase (MMP-8) in the presence of 1 mM Ca++ and the tripeptide degradation fragment and undegraded substrate were separated and measured by HPLC (Waters Alliance 2695 System with a reverse phase C-18 column).
Activity Charts
Bioactivity
Activity Types for Assay ALA3887580
IC50
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 180.21 | 2.78 | 2.78 |
| 368.39 | 2.85 | 2.85 |
| 427.46 | 4.22 | 4.22 |
| 426.42 | 2.77 | 2.77 |
| 366.37 | 2.75 | 2.75 |
| 487.51 | 4.23 | 4.23 |
| 379.46 | 3.72 | 3.72 |