Basic Information
ID: ALA3887698
Type: Binding
Description: Protease Assay: The inhibitory activity of certain compounds of Table A against HCV NS3-4A serine protease is determined in a homogenous assay using the full-length NS3-4A protein (genotype 1a, strain HCV-1) and a commercially available internally-quenched fluorogenic peptide substrate as described by Taliani, M., et al. 1996 Anal. Biochem. 240:60-67, which is incorporated by reference in its entirety.
Organism: Hepatitis C virus genotype 1a (isolate H)
Activity Charts
Bioactivity
Activity Types for Assay ALA3887698
IC50
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 663.88 | 3.24 | 3.24 |
| 777.04 | 3.77 | 3.77 |
| 830.15 | 3.63 | 3.63 |
| 816.12 | 3.10 | 3.10 |
| 793.04 | 3.01 | 3.01 |
| 846.15 | 2.86 | 2.86 |
| 832.12 | 2.33 | 2.33 |
| 850.11 | 2.42 | 2.42 |
| 745.00 | 2.87 | 2.87 |
| 816.12 | 3.24 | 3.24 |
| 816.12 | 3.24 | 3.24 |
| 802.10 | 2.85 | 2.85 |
| 856.19 | 4.16 | 4.16 |
| 842.16 | 3.77 | 3.77 |
| 842.16 | 3.77 | 3.77 |
| 842.16 | 3.77 | 3.77 |
| 828.13 | 3.38 | 3.38 |
| 828.13 | 3.38 | 3.38 |
| 828.13 | 3.24 | 3.24 |
| 834.11 | 3.19 | 3.19 |
| 816.12 | 3.24 | 3.24 |
| 802.10 | 2.85 | 2.85 |
| 802.10 | 2.70 | 2.70 |
| 830.15 | 3.63 | 3.63 |
| 856.19 | 4.16 | 4.16 |
| 860.15 | 3.72 | 3.72 |
| 868.20 | 4.30 | 4.30 |
| 856.19 | 4.16 | 4.16 |
| 882.23 | 4.69 | 4.69 |
| 872.19 | 3.40 | 3.40 |
| 858.20 | 4.38 | 4.38 |
| 882.23 | 4.69 | 4.69 |
| 842.16 | 3.77 | 3.77 |
| 842.16 | 3.77 | 3.77 |
| 828.13 | 3.38 | 3.38 |
| 828.13 | 3.38 | 3.38 |
| 842.16 | 3.77 | 3.77 |
| 884.20 | 3.54 | 3.54 |
| 837.06 | 2.38 | 2.38 |
| 811.02 | 1.85 | 1.85 |
| 858.16 | 3.01 | 3.01 |
| 874.18 | 4.11 | 4.11 |
| 874.18 | 4.11 | 4.11 |
| 856.19 | 4.16 | 4.16 |
| 828.13 | 3.38 | 3.38 |
| 754.01 | 3.75 | 3.75 |
| 892.22 | 5.20 | 5.20 |
| 856.19 | 4.16 | 4.16 |
| 900.24 | 4.18 | 4.18 |
| 846.15 | 3.56 | 3.56 |
| 874.20 | 3.64 | 3.64 |
| 856.19 | 4.21 | 4.21 |
| 842.16 | 3.77 | 3.77 |
| 828.13 | 3.38 | 3.38 |
| 745.00 | 3.05 | 3.05 |
| 726.98 | 4.09 | 4.09 |
| 844.18 | 4.02 | 4.02 |
| 830.15 | 3.63 | 3.63 |
| 884.24 | 4.94 | 4.94 |
| 858.20 | 4.41 | 4.41 |
| 858.16 | 3.01 | 3.01 |
| 752.98 | 3.29 | 3.29 |
| 851.13 | 3.67 | 3.67 |
| 851.13 | 3.67 | 3.67 |
| 910.11 | 3.30 | 3.30 |
| 892.12 | 3.01 | 3.01 |
| 874.13 | 2.71 | 2.71 |
| 906.15 | 3.40 | 3.40 |
| 888.16 | 3.10 | 3.10 |
| 918.14 | 2.85 | 2.85 |
| 688.89 | 1.36 | 1.36 |
| 830.15 | 3.63 | 3.63 |
| 828.13 | 3.38 | 3.38 |
| 880.16 | 4.26 | 4.26 |
| 886.21 | 3.79 | 3.79 |
| 872.19 | 3.40 | 3.40 |
| 846.19 | 4.24 | 4.24 |
| 844.18 | 4.00 | 4.00 |
| 724.92 | 2.51 | 2.51 |
| 878.14 | 4.02 | 4.02 |
| 858.20 | 4.38 | 4.38 |
| 830.15 | 3.63 | 3.63 |
| 844.18 | 4.02 | 4.02 |
| 816.12 | 3.24 | 3.24 |
| 830.15 | 3.63 | 3.63 |
| 842.16 | 3.77 | 3.77 |
| 858.16 | 3.01 | 3.01 |
| 830.15 | 3.63 | 3.63 |
| 830.15 | 3.61 | 3.61 |
| 832.17 | 3.85 | 3.85 |
| 816.12 | 3.24 | 3.24 |
| 822.09 | 3.17 | 3.17 |
| 836.11 | 3.56 | 3.56 |
| 850.14 | 3.95 | 3.95 |
| 892.17 | 4.41 | 4.41 |
| 872.23 | 4.80 | 4.80 |
| 844.18 | 4.02 | 4.02 |
| 858.20 | 4.40 | 4.40 |
| 830.15 | 3.63 | 3.63 |
| 872.23 | 4.79 | 4.79 |
| 844.18 | 4.02 | 4.02 |
| 858.20 | 4.41 | 4.41 |
| 870.21 | 4.55 | 4.55 |
| 858.20 | 4.41 | 4.41 |
| 870.21 | 4.55 | 4.55 |
| 844.18 | 3.99 | 3.99 |
| 846.19 | 4.24 | 4.24 |
| 830.15 | 3.63 | 3.63 |
| 858.20 | 4.40 | 4.40 |
| 872.23 | 4.79 | 4.79 |
| 860.22 | 4.63 | 4.63 |
| 818.14 | 3.48 | 3.48 |
| 858.20 | 4.38 | 4.38 |
| 898.22 | 3.93 | 3.93 |
| 870.17 | 3.15 | 3.15 |
| 844.13 | 2.62 | 2.62 |
| 900.20 | 2.78 | 2.78 |
| 872.19 | 3.40 | 3.40 |
| 804.11 | 3.09 | 3.09 |
| 818.14 | 3.48 | 3.48 |
| 844.18 | 4.02 | 4.02 |
| 872.23 | 4.80 | 4.80 |
| 844.18 | 4.02 | 4.02 |
| 870.21 | 4.55 | 4.55 |
| 842.16 | 3.77 | 3.77 |
| 872.23 | 4.80 | 4.80 |
| 860.22 | 4.63 | 4.63 |
| 860.22 | 4.63 | 4.63 |
| 892.17 | 4.41 | 4.41 |
| 846.17 | 3.29 | 3.29 |
| 884.20 | 3.54 | 3.54 |
| 912.25 | 4.32 | 4.32 |
| 900.24 | 4.18 | 4.18 |
| 886.21 | 3.79 | 3.79 |
| 914.27 | 4.57 | 4.57 |
| 886.21 | 3.79 | 3.79 |
| 872.19 | 3.40 | 3.40 |
| 894.18 | 4.65 | 4.65 |
| 876.19 | 4.36 | 4.36 |
| 886.21 | 3.79 | 3.79 |
| 914.27 | 4.57 | 4.57 |
| 884.24 | 4.94 | 4.94 |
| 912.30 | 5.72 | 5.72 |
| 811.06 | 3.98 | 3.98 |
| 830.15 | 3.63 | 3.63 |
| 860.18 | 2.99 | 2.99 |
| 878.14 | 4.02 | 4.02 |
| 795.02 | 2.66 | 2.66 |
| 811.06 | 3.29 | 3.29 |
| 797.04 | 2.86 | 2.86 |
| 831.48 | 3.08 | 3.08 |
| 858.20 | 4.45 | 4.45 |
| 844.18 | 4.02 | 4.02 |
| 878.62 | 4.24 | 4.24 |
| 842.16 | 3.82 | 3.82 |
| 811.06 | 3.25 | 3.25 |
| 858.20 | 4.41 | 4.41 |
| 822.09 | 3.54 | 3.54 |
| 876.13 | 4.70 | 4.70 |
| 876.18 | 3.96 | 3.96 |
| 860.13 | 4.70 | 4.70 |
| 829.12 | 3.86 | 3.86 |
| 839.12 | 3.74 | 3.74 |
| 867.17 | 4.24 | 4.24 |
| 836.11 | 4.25 | 4.25 |
| 867.17 | 4.47 | 4.47 |
| 873.13 | 4.40 | 4.40 |
| 839.12 | 3.51 | 3.51 |
| 839.12 | 3.41 | 3.41 |
| 842.12 | 2.91 | 2.91 |
| 846.11 | 4.69 | 4.69 |
| 846.11 | 4.69 | 4.69 |
| 846.11 | 4.69 | 4.69 |
| 847.09 | 4.96 | 4.96 |
| 847.09 | 4.96 | 4.96 |
| 851.12 | 4.29 | 4.29 |
| 856.14 | 3.16 | 3.16 |
| 858.12 | 4.76 | 4.76 |
| 858.12 | 4.76 | 4.76 |
| 858.12 | 4.76 | 4.76 |
| 860.13 | 4.70 | 4.70 |
| 788.07 | 2.46 | 2.46 |
| 799.01 | 2.59 | 2.59 |
| 843.15 | 2.14 | 2.14 |
| 860.22 | 4.63 | 4.63 |
| 884.24 | 4.80 | 4.80 |
| 884.24 | 4.94 | 4.94 |
| 921.24 | 2.60 | 2.60 |
| 921.24 | 2.61 | 2.61 |
| 907.21 | 2.22 | 2.22 |
| 858.20 | 4.41 | 4.41 |
| 844.18 | 4.02 | 4.02 |
| 870.21 | 4.55 | 4.55 |
| 856.19 | 4.16 | 4.16 |
| 816.12 | 3.24 | 3.24 |
| 823.07 | 3.31 | 3.31 |
| 842.16 | 3.77 | 3.77 |
| 826.08 | 1.80 | 1.80 |
| 884.20 | 3.54 | 3.54 |
| 868.20 | 4.30 | 4.30 |
| 844.18 | 4.02 | 4.02 |