Basic Information
ID: ALA3887904
Type: Binding
Description: Inhibition Assay: To initiate an assay, replicon cells were plated in the presence of a dilution series of test compound in the absence of G418. Typically, the assays were performed in a 96-well plate formate for manual operation, or a 384-well plate format for automated assay. Replicon cells and compound were incubated for 96 hours. At the end of the assay, cells were washed free of media and compound, and the cells were then lysed. RNA was quantified indirectly through detection of replicon-encoded NS3/4A protein levels, through an ELISA-based assay with an antibody specific for NS3/4A.
Organism: Hepatitis C virus genotype 1a (isolate H)
Activity Charts
Bioactivity
Activity Types for Assay ALA3887904
IC50
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 660.67 | 6.05 | 6.05 |
| 623.71 | 6.19 | 6.19 |
| 613.65 | 5.77 | 5.77 |
| 612.66 | 6.37 | 6.37 |
| 696.78 | 5.96 | 5.96 |
| 612.66 | 5.30 | 5.30 |
| 644.68 | 7.17 | 7.17 |
| 608.70 | 6.54 | 6.54 |
| 626.69 | 6.93 | 6.93 |
| 663.65 | 6.65 | 6.65 |
| 630.65 | 6.84 | 6.84 |
| 628.66 | 5.71 | 5.71 |
| 610.64 | 6.75 | 6.75 |
| 606.68 | 6.92 | 6.92 |
| 628.69 | 4.42 | 4.42 |
| 633.71 | 6.50 | 6.50 |
| 609.64 | 5.72 | 5.72 |
| 617.66 | 6.49 | 6.49 |
| 640.71 | 7.11 | 7.11 |
| 645.66 | 6.57 | 6.57 |
| 595.66 | 5.63 | 5.63 |
| 630.65 | 6.51 | 6.51 |
| 644.68 | 6.88 | 6.88 |
| 598.63 | 6.18 | 6.18 |
| 704.78 | 5.96 | 5.96 |
| 638.72 | 5.77 | 5.77 |
| 612.69 | 5.45 | 5.45 |
| 660.73 | 6.42 | 6.42 |
| 635.68 | 5.28 | 5.28 |
| 601.69 | 5.69 | 5.69 |
| 699.76 | 6.40 | 6.40 |
| 651.72 | 6.17 | 6.17 |
| 656.71 | 6.30 | 6.30 |
| 612.66 | 6.37 | 6.37 |
| 609.68 | 5.94 | 5.94 |
| 642.68 | 5.91 | 5.91 |
| 614.63 | 5.67 | 5.67 |
| 661.66 | 6.23 | 6.23 |
| 640.67 | 6.40 | 6.40 |
| 638.70 | 6.86 | 6.86 |
| 699.76 | 6.57 | 6.57 |
| 626.69 | 6.93 | 6.93 |
| 693.68 | 6.57 | 6.57 |
| 613.65 | 5.77 | 5.77 |
| 659.77 | 5.92 | 5.92 |
| 722.77 | 6.10 | 6.10 |
| 623.67 | 6.02 | 6.02 |
| 635.72 | 6.51 | 6.51 |
| 629.74 | 6.25 | 6.25 |
| 612.66 | 6.37 | 6.37 |
| 613.65 | 5.77 | 5.77 |
| 670.79 | 6.29 | 6.29 |
| 615.71 | 6.00 | 6.00 |
| 640.71 | 7.15 | 7.15 |
| 611.66 | 4.72 | 4.72 |
| 624.70 | 5.38 | 5.38 |
| 681.77 | 6.62 | 6.62 |
| 626.69 | 6.93 | 6.93 |
| 653.69 | 5.40 | 5.40 |
| 612.66 | 5.27 | 5.27 |
| 627.67 | 6.08 | 6.08 |
| 624.67 | 6.84 | 6.84 |
| 647.10 | 7.03 | 7.03 |
| 626.71 | 6.01 | 6.01 |
| 626.69 | 6.68 | 6.68 |
| 613.65 | 5.77 | 5.77 |
| 612.66 | 6.37 | 6.37 |
| 628.63 | 6.89 | 6.89 |
| 625.68 | 5.03 | 5.03 |
| 609.68 | 5.94 | 5.94 |
| 717.75 | 6.87 | 6.87 |
| 637.67 | 6.92 | 6.92 |
| 710.81 | 6.52 | 6.52 |
| 626.69 | 6.76 | 6.76 |
| 625.68 | 5.64 | 5.64 |
| 599.64 | 5.53 | 5.53 |
| 637.74 | 6.75 | 6.75 |
| 717.75 | 6.71 | 6.71 |
| 652.63 | 5.77 | 5.77 |
| 642.68 | 5.73 | 5.73 |
| 584.63 | 4.96 | 4.96 |
| 558.64 | 5.44 | 5.44 |
| 612.69 | 5.57 | 5.57 |
| 713.78 | 6.96 | 6.96 |