Assay Report Card

Basic Information

ID: ALA3888194

Type: Binding

Description: Nav1.7 In Vitro PX Assay: HEK 293 cells stably transfected with human Nav1.7 were recorded in whole cell voltage clamp mode with the PatchXpress automated electrophysiology system (Molecular Devices, LLC, Sunnyvale, Calif.). Compound effects were measured on a partially inactivated state of the sodium channel. Cells were clamped to a holding potential yielding 20 to 50% inactivation. To elicit sodium current, channels were activated by pulsing to -10 mV for 20 msec. This voltage protocol was repeated at a rate of 0.1 Hz throughout the experiment. A single concentration of test compound was applied to cells for a duration of 3 minutes.

Cell type: Sf9

Activity Charts

Compound Summary

Parent Molecular WeightALogPPolar Surface Area
556.964.654.65
557.035.425.42
534.544.844.84
525.955.255.25
525.564.044.04
545.024.804.80
566.565.585.58
533.535.225.22
550.965.125.12
568.974.354.35
539.524.744.74
503.544.464.46
437.483.673.67
499.523.513.51
521.985.425.42
560.034.214.21
541.515.535.53
511.533.703.70
544.924.784.78
548.575.155.15
520.524.544.54
535.554.994.99
521.985.425.42
535.005.665.66
533.564.474.47
533.015.225.22
549.585.385.38
521.534.604.60
542.624.964.96
536.564.364.36
569.545.645.64
603.475.065.06
476.313.553.55
521.534.604.60
576.614.724.72
552.535.285.28
519.353.803.80
539.524.744.74
556.964.654.65
536.975.055.05
477.503.193.19
495.493.333.33
511.563.673.67
518.364.414.41
499.523.823.82
554.965.195.19
507.965.115.11
534.544.844.84
560.995.255.25
531.595.245.24
556.964.654.65
511.485.475.47
597.004.284.28
515.984.194.19
546.544.474.47
507.965.115.11
516.554.704.70
560.395.905.90
582.014.764.76
509.494.734.73
527.484.874.87
523.525.045.04
555.975.265.26
522.604.854.85
537.985.125.12
509.494.734.73
517.564.854.85
554.005.865.86
555.975.265.26
525.955.255.25
523.543.583.58
533.343.973.97
566.565.585.58
526.934.644.64
539.524.744.74
536.595.475.47
566.525.155.15
535.554.914.91
537.985.125.12
546.584.714.71
575.505.335.33
530.994.414.41
498.524.334.33
492.493.993.99
485.544.524.52
538.974.514.51
570.005.565.56
483.524.274.27
540.964.954.95
559.505.615.61
582.565.315.31
549.014.924.92
497.554.974.97
528.594.574.57
533.015.225.22
539.524.744.74
534.504.634.63
535.353.503.50
559.505.615.61
527.484.874.87
557.515.355.35
521.534.604.60
541.515.475.47
487.544.764.76
534.544.844.84
536.975.055.05
573.415.595.59
557.965.705.70
509.494.734.73
501.565.075.07
509.494.734.73
554.965.195.19
555.975.265.26
522.514.004.00
535.554.914.91
551.005.365.36
523.525.045.04
542.405.765.76
490.343.863.86
552.534.984.98
537.985.125.12
534.544.844.84
540.594.994.99
547.045.535.53
501.565.075.07
587.536.166.16
525.955.255.25
517.564.774.77
533.015.225.22
567.005.065.06
551.005.365.36
535.005.665.66
491.504.594.59
543.004.404.40
549.014.924.92
561.385.305.30
556.964.654.65
583.025.755.75
546.544.474.47
487.544.764.76
519.313.583.58
519.353.803.80
527.574.604.60
542.624.884.88
536.595.475.47
516.964.024.02
525.955.255.25
538.514.674.67
539.524.744.74
543.945.395.39
584.995.205.20
546.584.714.71
541.515.475.47
556.645.355.35
505.534.904.90
492.493.993.99
523.503.393.39
552.534.984.98
506.524.304.30
507.965.115.11
517.564.774.77
515.595.585.58
521.534.604.60
536.975.055.05
547.045.535.53
534.544.844.84
552.535.285.28
537.985.125.12
568.995.505.50
525.955.255.25
542.624.884.88
537.985.125.12
539.975.565.56
543.945.395.39
546.584.714.71
472.913.713.71
517.564.774.77
559.505.615.61
542.625.045.04
644.116.796.79
519.535.605.60
542.624.884.88
491.504.594.59
539.975.565.56
508.533.863.86
525.955.255.25
560.495.015.01
536.975.055.05
397.412.792.79
501.565.025.02
564.574.854.85
555.975.265.26
530.544.774.77
557.035.425.42
580.884.414.41
505.534.904.90
526.934.644.64
567.994.454.45
522.974.814.81
589.444.674.67
501.565.075.07
498.524.334.33
531.575.475.47
539.524.744.74
542.504.874.87
570.525.425.42
501.454.194.19
537.985.125.12
570.525.425.42
476.313.553.55
543.945.395.39
541.515.535.53
567.994.454.45
584.555.725.72
562.584.414.41
530.544.774.77
520.524.544.54
521.985.425.42
521.985.425.42
509.494.734.73
521.985.425.42
562.584.414.41
557.515.205.20
505.534.904.90
537.985.125.12
516.554.704.70
546.584.714.71
518.984.914.91
536.975.055.05
492.493.993.99
570.525.425.42
543.945.395.39
553.524.674.67
585.984.594.59
556.046.026.02
530.585.015.01
557.515.205.20
568.995.505.50
539.975.565.56
560.005.865.86
560.615.185.18
539.975.565.56
530.565.405.40
567.994.454.45
537.985.125.12
523.525.045.04
556.504.814.81
568.535.005.00
522.974.814.81
543.005.115.11
509.494.734.73
491.504.594.59
530.544.774.77
552.534.984.98
483.524.584.58
521.534.604.60
527.574.604.60
519.555.215.21
525.955.255.25
525.955.255.25
510.754.204.20
556.964.554.55
546.584.714.71
518.984.914.91
555.975.265.26
561.984.924.92
511.585.055.05
539.975.565.56
538.974.514.51
533.015.225.22
536.014.184.18
525.955.255.25
527.484.874.87
522.604.854.85
522.514.004.00
542.625.045.04
528.474.274.27
559.505.615.61
542.624.884.88
538.974.514.51
525.955.255.25
557.035.425.42
556.964.654.65
523.913.293.29
507.504.724.72
570.525.425.42
535.553.483.48
582.014.764.76
549.014.924.92
516.964.164.16
539.975.565.56
582.014.764.76
508.944.504.50
546.584.714.71
491.504.594.59
546.584.714.71
546.544.474.47
533.015.225.22
487.343.353.35
559.625.795.79
523.525.045.04
505.534.904.90
523.525.045.04
584.555.725.72
533.015.225.22
505.534.904.90
586.525.145.14
526.934.644.64
534.544.844.84
539.975.565.56
588.515.555.55
524.514.444.44
592.944.834.83
471.924.324.32
536.975.055.05
552.535.285.28
561.984.924.92
567.005.065.06
539.975.565.56
533.015.225.22
536.564.414.41
512.564.454.45
550.965.125.12
541.515.475.47
584.555.725.72
522.514.004.00
569.546.026.02
507.965.115.11
540.964.954.95
555.975.265.26
509.494.734.73
582.565.315.31
550.015.965.96
539.975.565.56
492.493.993.99
515.554.394.39
530.544.774.77
537.545.355.35
516.514.474.47
525.534.564.56
551.005.365.36
570.525.425.42
511.585.225.22
525.955.255.25
589.444.674.67
584.995.205.20
592.944.834.83
518.574.274.27
584.995.205.20
560.395.905.90
517.564.774.77
538.514.674.67
525.955.255.25
432.852.842.84
521.534.604.60
537.985.125.12
531.575.475.47
575.505.335.33
510.484.134.13
566.565.585.58
505.534.904.90
545.475.015.01
580.574.554.55
524.514.444.44
498.564.574.57
585.984.594.59
534.544.844.84
543.945.395.39
533.954.384.38
506.524.304.30
489.554.334.33
527.484.874.87
506.524.304.30
567.005.065.06
481.484.284.28
550.544.544.54
502.943.773.77
522.514.004.00
555.975.265.26
525.955.255.25
516.514.474.47
519.555.165.16
559.505.615.61
570.525.425.42
538.514.674.67
526.934.644.64
548.575.155.15
481.533.683.68
553.975.795.79
532.554.404.40
535.554.914.91
550.544.544.54
555.535.785.78
541.515.475.47
602.046.916.91
577.495.755.75
535.554.914.91
575.424.284.28
577.434.534.53
560.924.914.91
507.544.474.47
584.555.725.72
576.914.504.50
491.504.594.59
569.546.026.02
548.575.155.15
575.956.136.13
505.534.904.90
576.015.235.23
566.565.585.58
568.006.106.10
550.965.125.12
537.985.125.12
535.554.914.91
520.524.544.54
510.484.134.13
540.964.954.95
521.985.425.42
551.005.365.36
522.974.814.81
544.034.834.83
588.515.555.55
567.005.065.06
556.436.076.07
564.574.854.85
548.575.155.15
530.873.783.78
534.004.614.61
551.554.614.61
560.495.015.01
499.513.723.72
536.975.055.05
532.554.404.40
516.514.474.47
566.565.585.58
521.985.425.42
571.965.935.93
495.534.324.32
555.535.785.78
554.605.215.21
539.525.065.06
513.553.903.90
536.544.314.31
570.525.425.42
539.975.565.56
509.494.734.73
526.934.644.64
521.534.604.60
535.554.914.91
522.604.854.85
525.955.255.25
560.495.015.01
539.975.565.56
556.046.026.02
543.945.395.39
584.555.725.72
537.985.125.12
541.515.475.47
521.985.425.42
521.985.425.42
530.014.224.22
567.994.454.45
527.484.874.87
521.985.425.42
526.934.644.64
516.514.474.47
523.525.045.04
564.985.455.45
575.505.495.49
525.955.255.25
556.964.654.65
545.475.015.01
533.015.225.22
513.585.335.33
551.005.365.36
555.975.265.26
584.555.725.72
523.975.865.86
542.934.774.77
518.574.274.27
568.535.005.00
521.534.604.60
520.953.253.25
518.554.174.17
523.525.045.04
541.515.475.47
477.503.193.19
518.554.174.17
523.525.045.04
521.985.425.42
534.544.844.84
506.463.383.38
560.495.015.01
517.564.774.77
521.985.425.42
455.473.803.80
588.515.555.55
549.014.924.92
533.015.225.22
558.494.594.59
512.594.874.87
539.524.744.74
554.965.195.19
567.455.875.87
542.624.884.88
519.353.803.80
502.534.404.40
559.505.615.61
535.554.914.91
509.494.734.73
552.534.984.98
528.594.574.57
509.523.323.32
517.564.774.77
566.565.585.58
500.584.134.13
509.494.734.73
538.514.674.67
555.975.265.26
506.524.304.30
537.985.125.12
526.934.644.64
522.514.004.00
534.544.844.84
543.945.395.39
550.965.125.12
539.504.074.07
497.503.053.05
557.425.475.47
519.555.215.21
492.493.993.99
499.523.513.51
567.005.065.06
543.945.395.39
542.405.765.76
533.384.054.05
582.014.764.76
492.493.993.99
515.554.394.39
547.494.874.87
507.544.474.47
559.505.615.61
557.965.705.70
550.965.125.12
516.514.474.47
516.554.704.70
453.504.444.44
519.555.215.21
570.525.425.42
575.424.424.42
624.965.575.57
513.554.044.04
509.494.734.73
511.585.055.05
550.965.125.12
536.015.735.73
554.965.195.19
536.975.055.05
531.595.245.24
577.495.755.75
493.495.035.03
522.604.854.85
560.924.914.91
545.024.794.79
513.553.903.90
538.483.933.93
501.565.075.07
521.534.604.60
579.975.065.06
541.515.475.47
567.994.454.45
526.934.644.64
492.493.993.99
522.514.004.00
550.544.544.54
538.974.514.51
492.493.993.99
551.005.365.36
541.515.185.18
507.965.115.11
505.534.904.90
574.954.694.69
523.525.045.04
537.985.125.12
555.954.584.58
552.535.285.28
563.414.284.28
560.924.914.91
575.505.495.49
507.965.115.11
570.525.425.42
507.423.843.84
555.975.265.26
536.975.055.05
497.554.664.66
549.383.643.64
539.524.744.74
525.955.255.25
536.544.314.31
521.985.425.42
479.493.693.69
525.955.255.25
576.015.235.23
525.955.255.25
505.534.904.90
436.452.852.85
540.504.144.14
498.564.574.57
521.985.425.42
556.645.355.35
502.943.633.63
536.975.055.05
494.303.693.69
534.544.844.84
543.945.395.39
549.383.423.42
505.534.904.90
523.525.045.04
523.525.125.12
542.504.874.87
555.975.265.26
513.454.574.57
568.995.505.50
563.045.235.23
551.994.754.75
512.594.874.87
521.534.604.60
551.005.365.36
525.955.255.25
530.565.405.40
491.504.594.59
520.524.544.54
535.005.665.66
525.955.255.25
521.985.425.42
584.995.205.20
526.934.644.64
568.534.214.21
510.884.264.26
537.985.125.12
523.594.914.91