Basic Information
ID: ALA3888195
Type: Binding
Description: Nav1.5 In Vitro PX Assay: 293 cells stably transfected with Nav 1.5 were recorded in whole cell voltage clamp mode with the PatchXpress automated electrophysiology system according the manufacturer's specifications (Molecular Devices, LLC, Sunnyvale, Calif.). Cells were held at a holding potential of -50 mV to inactivate sodium channels. To elicit sodium currents the voltage was changed -120 mV to recover a portion of the channels, followed by delivery of test pulses of 20 msec duration to 0 mV, at 0.1 Hz. A single concentration of test compound was applied to cells for a duration of 5 minutes.
Format: BAO_0000219
Cell type: 293
Target: Sodium channel protein type V alpha subunit(ALA1980)
Document: ALA3886193
BindingDB Source: 7789
Activity Charts
Bioactivity
Activity Types for Assay ALA3888195
IC50
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 557.03 | 5.42 | 5.42 |
| 560.39 | 5.90 | 5.90 |
| 567.00 | 5.06 | 5.06 |
| 543.00 | 5.11 | 5.11 |
| 523.52 | 5.04 | 5.04 |
| 567.00 | 5.06 | 5.06 |
| 522.51 | 4.00 | 4.00 |
| 543.94 | 5.39 | 5.39 |
| 481.48 | 4.28 | 4.28 |
| 525.95 | 5.25 | 5.25 |
| 575.95 | 6.13 | 6.13 |
| 567.00 | 5.06 | 5.06 |
| 535.55 | 4.91 | 4.91 |
| 541.51 | 5.18 | 5.18 |