Basic Information
ID: ALA3888214
Type: Binding
Description: Inhibition Assay: Assays for slow-onset inhibitors were carried out by adding 1 nM PaMTIP into reaction mixtures at 25 °C. containing 100 mM Hepes, pH 7.4, 100 mM phosphate, pH 7.4, 2 mM MTI, 5 mM DTT, 0.5 unit of xanthine oxidase and variable inhibitor concentration. Inhibitors were present at >10 times the enzyme concentration. Assays for MTA inhibition used 200 μM MTI. Controls having no enzyme and no inhibitor were included in all of the inhibition assays. Ki is the inhibition constant.
Activity Charts
Bioactivity
Activity Types for Assay ALA3888214
Ki
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 268.34 | 0.06 | 0.06 |
| 298.37 | -0.57 | -0.57 |
| 294.38 | 0.41 | 0.41 |
| 310.38 | -0.48 | -0.48 |
| 310.38 | -0.78 | -0.78 |
| 372.45 | 0.65 | 0.65 |
| 322.43 | 1.19 | 1.19 |