Basic Information
ID: ALA3888289
Type: Binding
Description: Functional Assay: The functional properties of the ligands were determined by 86Rb+ efflux assays in cells expressing α3β4 and α4β2 nAChR subtypes. The functional activity of each ligand was measured for its agonism, antagonism and desensitization ability. Agonist activity for each of the ligands was tested at eight different concentrations. The responses were compared to that stimulated by 100 μM (−)-nicotine, a near maximally effective concentration. The full concentration-effect curves generated potency (EC50) and efficacy (Emax) of each ligand.
Activity Charts
Bioactivity
Activity Types for Assay ALA3888289
EC50
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 162.24 | 1.85 | 1.85 |
| 211.27 | 1.80 | 1.80 |
| 260.34 | 1.34 | 1.34 |
| 258.36 | 2.67 | 2.67 |
| 242.32 | 1.89 | 1.89 |
| 274.36 | 1.64 | 1.64 |