Basic Information
ID: ALA3888333
Type: Binding
Description: SPR Competitive Binding Assay: SPR interaction analyses were performed with a Biacore 2000, using Biacore 2000 Control Software v3.2 and BIAevaluation v4.1 analysis software (Biacore) as described in Mol Cancer Ther 7:2621 (2008). For the competitive binding assays and the Ki determination, PtdIns(3,4,5)phosphate-biotin labeled liposomes (Echelon Biosciences) and SA chips were used with increasing concentrations of the compound tested.
Format: BAO_0000357
Target: Serine/threonine-protein kinase AKT(ALA4282)
Document: ALA3886664
BindingDB Source: 7909
Activity Charts
Bioactivity
Activity Types for Assay ALA3888333
Kd
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 256.31 | 0.92 | 0.92 |
| 298.35 | 1.30 | 1.30 |
| 416.48 | 0.96 | 0.96 |
| 497.92 | 3.44 | 3.44 |
| 410.57 | 4.42 | 4.42 |
| 409.62 | 5.80 | 5.80 |
| 284.37 | 1.48 | 1.48 |
| 326.40 | 1.86 | 1.86 |
| 424.59 | 4.73 | 4.73 |
| 438.62 | 4.98 | 4.98 |
| 466.67 | 5.72 | 5.72 |
| 496.66 | 4.52 | 4.52 |
| 482.63 | 4.59 | 4.59 |
| 440.59 | 3.91 | 3.91 |
| 297.40 | 2.68 | 2.68 |
| 325.46 | 3.46 | 3.46 |
| 353.51 | 4.24 | 4.24 |
| 437.68 | 6.58 | 6.58 |
| 465.73 | 7.36 | 7.36 |
| 493.78 | 8.14 | 8.14 |
| 423.65 | 6.11 | 6.11 |
| 437.68 | 6.36 | 6.36 |
| 465.73 | 7.10 | 7.10 |
| 467.66 | 5.43 | 5.43 |
| 495.71 | 5.91 | 5.91 |
| 481.68 | 5.98 | 5.98 |
| 439.65 | 5.29 | 5.29 |
| 488.70 | 4.45 | 4.45 |
| 371.43 | 0.53 | 0.53 |
| 1050.98 | ||
| 469.50 | 1.70 | 1.70 |
| 517.98 | 3.81 | 3.81 |